Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kun-Po Li"'
Autor:
Kun-Po Li, Brian H. Ladle, David A. Hildeman, Sharmila Shanmuganad, Allyson Sholl, Sema Kurtulus
Publikováno v:
Cell Death and Differentiation
Most effector CD8+ T cells die, while some persist and become either “effector” (TEM) or “central” (TCM) memory T cells. Paradoxically, effector CD8+ T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c75eb258b4751b2ece8f7519bc8a854
https://doi.org/10.1038/s41418-019-0410-x
https://doi.org/10.1038/s41418-019-0410-x
Autor:
Kun-Po Li, Sharmila Shanmuganad, David A. Hildeman, Kaitlin R. Carroll, Jonathan D. Katz, Michael B. Jordan
Publikováno v:
Immunological Reviews. 277:21-43
T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T cell receptors (TCRs) and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb136889f745f15f40b7bf7b1531147f
https://doi.org/10.1111/imr.12538
https://doi.org/10.1111/imr.12538
Autor:
David A. Hildeman, Carla M. Cuda, Kathrin Kalies, Harris Perlman, Eron Roy, Anke Fähnrich, Kun-Po Li, H. Leighton Grimes
Publikováno v:
The Journal of Immunology. 198:257-269
CD8αα TCRαβ+ intestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis, although mechanisms controlling their development and peripheral homeostasis remain unclear. In this study, we examined the spatiotempor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc91643af96a1102daa6ef576b9a5dd
https://doi.org/10.4049/jimmunol.1601200
https://doi.org/10.4049/jimmunol.1601200
Autor:
Azeb Haile, Jonathan D. Powell, Kun-Po Li, Maggie J. Phillips, Alexandra B. Pucsek, Brian H. Ladle, David A. Hildeman, Christopher Gamper, Elizabeth M. Jaffee
Publikováno v:
Proceedings of the National Academy of Sciences. 113:10631-10636
DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c10368f6fedc5436872b48bca0209c6
https://doi.org/10.1073/pnas.1524490113
https://doi.org/10.1073/pnas.1524490113
Autor:
Kun-Po Li, David A. Hildeman, Maha Almanan, Rebekah Karns, Senad Divanovic, Claire A. Chougnet, Jana Raynor
Publikováno v:
The Journal of Immunology. 195:944-952
Regulatory T cells (Tregs), a subset of CD4+ T cells, dramatically accumulate with age in humans and mice and contribute to age-related immune suppression. Recently, we showed that a majority of accumulating Tregs in aged mice expressed low levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5087315ed3ea8d81ce729dbd2aecb1
https://doi.org/10.4049/jimmunol.1500443
https://doi.org/10.4049/jimmunol.1500443
Publikováno v:
Cellular & Molecular Immunology. 12:354-365
Regulatory T (Treg) cells play a critical role in the maintenance of tolerance. B-1a cells belong to a specific and functionally important B-cell subset that exerts its regulatory role through the production of IL-10. While IL-10 has been correlated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92cc91d8a0f12f1ddfc3e85bb74fccf
https://doi.org/10.1038/cmi.2014.56
https://doi.org/10.1038/cmi.2014.56
Autor:
Kyle K Payne, Ricardo Chaurio Gonzalez, Jairo Perez Sanz, Carmen Maria Anadon Galindo, Subir Biswas, Jessica A Mine, Alfredo Perales-Puchalt, Evgenii Tsiganov, Tara Lee Costich, Carly M Harro, Aubrey K Marrs, Jason Lajoie, Kun-Po Li, Michael Ophir, Ugur Eskiocak, Michael Schmidt, Dmitry I Gabrilovich, Jose R Conejo-Garcia
Publikováno v:
The Journal of Immunology. 202:194.2-194.2
Ovarian carcinoma microenvironmental T cells exert clinically relevant pressure against malignant progression; however current immunotherapies rarely induce ovarian cancer regression. Here we investigate CD277-containing butyrophilin 3A1 (BTN3A1), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e2d4ec632c70d46db778ac956d1dc6
https://doi.org/10.4049/jimmunol.202.supp.194.2
https://doi.org/10.4049/jimmunol.202.supp.194.2
Autor:
Sema Kurtulus, David A. Hildeman, Marc Pellegrini, Kun-Po Li, Toe J, Jana Raynor, Pulak Tripathi, Allyson Sholl
During the effector CD8+ T-cell response, transcriptional differentiation programs are engaged that promote effector T cells with varying memory potential. Although these differentiation programs have been used to explain which cells die as effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef8a8fc5b59273ee8e12b7350393dfe
https://europepmc.org/articles/PMC4262773/
https://europepmc.org/articles/PMC4262773/
Autor:
Kun-Po Li, Anke Fähnrich, Eron Roy, Carla Cuda, H Leighton Grimes, Harris Perlman, Kathrin Kalies, David A Hildeman
Publikováno v:
The Journal of Immunology. 196:121.9-121.9
DN T cells (CD4−CD8α−TCRαβ+) and CD8αα T cells compose a major lymphocyte population in the intestine and promote gut homeostasis. Their thymic development, i.e. agonist selection, has been shown to be controlled by the pro-apoptotic factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e0ae817c7afe2c72b2d72a6d2cb104
https://doi.org/10.4049/jimmunol.196.supp.121.9
https://doi.org/10.4049/jimmunol.196.supp.121.9
Publikováno v:
The Journal of Immunology. 194:51.13-51.13
Thymocyte negative selection is thought to cull T cells with strong self-reactivity and maintain T cells with non-self-specificity. While initial work implicated Bim as a critical mediator of thymocyte negative selection, its role in the process has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498f03560dc0ae983d666dfd3b7708ba
https://doi.org/10.4049/jimmunol.194.supp.51.13
https://doi.org/10.4049/jimmunol.194.supp.51.13