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Akademický článek

Mulberry and Hippophae-based solid beverage promotes weight loss in rats by antagonizing white adipose tissue PPARγ and FGFR1 signaling

Autor: Xiao-Ting Zhou, An-Qi Zhu, Xiao-Min Li, Ling-Yue Sun, Jian-Gang Yan, Nin Luo, Shi-Sheng Chen, Zebo Huang, Xin-Liang Mao, Kun-Ping Li

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Obesity, a multifactorial disease with many complications, has become a global epidemic. Weight management, including dietary supplementation, has been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic eluc

Externí odkaz: https://doaj.org/article/9644a0d0b1934e3b9778682e9db750d6

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Akademický článek

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

Autor: Yilin Wang, Aneesah Khan, Aristotelis Antonopoulos, Laura Bouché, Christopher D. Buckley, Andrew Filer, Karim Raza, Kun-Ping Li, Barbara Tolusso, Elisa Gremese, Mariola Kurowska-Stolarska, Stefano Alivernini, Anne Dell, Stuart M. Haslam, Miguel A. Pineda

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model

Externí odkaz: https://doaj.org/article/72dfa842353344fcbc847fcee0909af2

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Akademický článek

Clinical experience in diagnosis and treatment of malignant gastrointestinal stromal tumors

Autor: Fan Lin, Jie Cao, Wei-Li Gu, Shao-Feng Fan, Kun-Ping Li, Hong Du, Guo-Qin Chen, Min-Jie Wen, Li-Hua Dai, Yue-Yuan Lai

Publikováno v: Kaohsiung Journal of Medical Sciences, Vol 28, Iss 4, Pp 212-215 (2012)

This study investigated the clinical pathologic character of malignant gastrointestinal stromal tumors (MGIST), their treatment with surgery, and evaluated the efficacy of imatinib postoperation. A total of 68 MGIST patients were enrolled. Of these,

Externí odkaz: https://doaj.org/article/c0e44494829042299898421cec0f4c49

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[Mechanism of Liangfu Pills in treatment of functional dyspepsia: based on network pharmacology and experimental verification]

Autor: Jie-Ying, He, Bei, Gui, Yan-Fen, Chen, Yong-Qin, Yin, Shu-Hong, Tao, Zhi-Bin, Shen, Kun-Ping, Li, Jiang-Bo, Fu, Ling, Wei

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 47(14)

This study aims to explore the potential mechanism of Liangfu Pills in the treatment of functional dyspepsia(FD) based on network pharmacology and molecular docking, and verify the mechanism by animal experiment. The active components of Liangfu Pill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de73065b88861e2d80e1fc496c12149d
https://pubmed.ncbi.nlm.nih.gov/35850844

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Hederacolchiside C inhibits Enterovirus 71 propagation through activating innate immunity

Autor: Ikhlas A. Khan, Yan-Er Wang, Yanli Liu, Shilin Yang, Kun-Ping Li, Naixin Kang, Jianping Zhao, Qiongming Xu

Publikováno v: Journal of Infection and Chemotherapy. 25:1074-1077

Enterovirus 71 (EV71), a newly emerging life-threatening pathogen induces hand-foot-mouth disease (HFMD), no effective vaccines or specific anti-viral treatments are currently available. In this study, the activity of hederacolchiside C (HSC) against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c6ca0f745622e73e2c441910725074
https://doi.org/10.1016/j.jiac.2019.07.010

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Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

Autor: Karim Raza, Christopher D. Buckley, Laura Bouché, Aneesah M. Khan, Mariola Kurowska-Stolarska, Elisa Gremese, Andrew Filer, Miguel A. Pineda, Stuart M. Haslam, Stefano Alivernini, Kun-Ping Li, Aristotelis Antonopoulos, Anne Dell, Yilin Wang, Barbara Tolusso

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

In healthy joints, synovial fibroblasts (SFs) provide the microenvironment required to mediate homeostasis, but these cells adopt a pathological function in rheumatoid arthritis (RA). Carbohydrates (glycans) on cell surfaces are fundamental regulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd3575f611c44bd5d5549915bdc1de5
http://europepmc.org/articles/PMC8058094

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Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats

Autor: Jiao Guo, Kun-Ping Li, Min Yuan, Xiang-Lu Rong, Yang Yu, Chu-Mei Zhang, Jeremy E. Turnbull

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Evidence-based Complementary and Alternative Medicine : eCAM

The progressive increase of metabolic diseases underscores the necessity for developing effective therapies. Although we found Tian-Huang formula (THF) could alleviate metabolic disorders, the underlying mechanism remains to be fully understood. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f621ff02d6a5a61f48553fe9395f23
https://doaj.org/article/df9da09d41a4470db7e7ef54956c824a

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