Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Kun-Che Chang"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110100- (2024)
Summary: Retinal ganglion cell (RGC) differentiation is tightly controlled by extrinsic and intrinsic factors. Growth and differentiation factor 15 (GDF-15) promotes RGC differentiation, opposite to GDF-11 which inhibits RGC differentiation, both in
Externí odkaz:
https://doaj.org/article/88ed468deb2a4fad955e3eb4570ea27e
Autor:
Ke Ning, Mohajeet B. Bhuckory, Chien-Hui Lo, Brent E. Sendayen, Tia J. Kowal, Ming Chen, Ruchi Bansal, Kun-Che Chang, Douglas Vollrath, Nicolas F. Berbari, Vinit B. Mahajan, Yang Hu, Yang Sun
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Primary cilia are conserved organelles that integrate extracellular cues into intracellular signals and are critical for diverse processes, including cellular development and repair responses. Deficits in ciliary function cause multisystemic
Externí odkaz:
https://doaj.org/article/e3cde6ac1f29410caad2250851acad47
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 4, Pp 3391-3405 (2023)
This study aimed to investigate the regulatory role of Aldo-keto reductase family 1 member B1 (AKR1B1) in glioma cell proliferation through p38 MAPK activation to control Bcl-2/BAX/caspase-3 apoptosis signaling. AKR1B1 expression was quantified in no
Externí odkaz:
https://doaj.org/article/08b39bacb1514d84aeba4e8535d2324b
Autor:
Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M. Williams, Takaaki Kuwajima, Kun-Che Chang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons are the only neurons in the retina that transmit visual signals from the eye to the brain via the optic nerve (ON). Unfortunately, they do not regener
Externí odkaz:
https://doaj.org/article/65c1f36d05de4c6aa38bd2db14f7b436
Autor:
Takahiko Noro, Sahil H. Shah, Yuqin Yin, Riki Kawaguchi, Satoshi Yokota, Kun-Che Chang, Ankush Madaan, Catalina Sun, Giovanni Coppola, Daniel Geschwind, Larry I. Benowitz, Jeffrey L. Goldberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Adult central nervous system (CNS) axons fail to regenerate after injury, and master regulators of the regenerative program remain to be identified. We analyzed the transcriptomes of retinal ganglion cells (RGCs) at 1 and 5 days after optic
Externí odkaz:
https://doaj.org/article/38eab275dbca49d18b7dd652b839091d
Autor:
Khushboo Irshad, Yu-Kai Huang, Paul Rodriguez, Jung Lo, Benjamin E. Aghoghovwia, Yuan Pan, Kun-Che Chang
Publikováno v:
Brain Sciences, Vol 13, Iss 10, p 1424 (2023)
Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progress
Externí odkaz:
https://doaj.org/article/6381f47f701e439a90a00025f277b509
Autor:
Kun-Che Chang
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 477-481 (2022)
SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases. Post-translational modification of Sox proteins is known to alter their functions in the centr
Externí odkaz:
https://doaj.org/article/e34ec48a43094af7aae6bba72f43ac2e
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production, which is highly associated with normal physiological homeostasis and the pathogenesis of diseases, particularly ocular diseases. Autophagy is a self
Externí odkaz:
https://doaj.org/article/696d4c38a7434206a3cab188b72b1a74
Autor:
Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng-I Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang Li
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7300 (2023)
Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect
Externí odkaz:
https://doaj.org/article/1399ac2f79764234bc1f06d12478eb00
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15088 (2022)
The occurrence of Alzheimer’s disease has been associated with the accumulation of beta-amyloid (β-amyloid) plaques. These plaques activate microglia to secrete inflammatory molecules, which damage neurons in the brain. Thus, understanding the und
Externí odkaz:
https://doaj.org/article/8a0b60b7085d4c6c83b4435bef5690ca