Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kun Yi Hsin"'
Publikováno v:
Animals, Vol 13, Iss 16, p 2584 (2023)
This study aimed to delineate the fundamental skin histology and its association with feathers in broilers and native Red-Feather (RF) chickens and further elucidate their thermal alterations in respect to the defeathering effect by scalding. Compari
Externí odkaz:
https://doaj.org/article/7ee00df907374f2687ec6fb807e4f990
Publikováno v:
Animals, Vol 12, Iss 22, p 3145 (2022)
Current soft scalding in broilers is not applicable to various strains of chickens with different market weights and ages. This study aimed to examine the effectiveness of soft (57 °C for 120 s) and hard (60 °C for 60 s) scalding on defeathering an
Externí odkaz:
https://doaj.org/article/62e579e4030449f1ad503a626a437676
Autor:
Wen-Chi Hsiao, Kun-Yi Hsin, Zhong-Wei Wu, Jen-Shin Song, Yen-Nan Yeh, Yan-Fu Chen, Chia-Hua Tsai, Pei-Hsuan Chen, Kak-Shan Shia, Chun-Ping Chang, Ming-Shiu Hung
Publikováno v:
Bioorganic chemistry. 130
Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor and a therapeutic target for metabolic disorders. Numerous CB1 antagonists have been developed, but their functional selectivities and bias towards G protein or β-arrestin signaling have n
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83922 (2013)
Increased availability of bioinformatics resources is creating opportunities for the application of network pharmacology to predict drug effects and toxicity resulting from multi-target interactions. Here we present a high-precision computational pre
Externí odkaz:
https://doaj.org/article/4f097faf2dc64a90b8ac8a8ebc857a98
Publikováno v:
Biochemical pharmacology. 166
Leptin is an adipokine predominantly secreted by adipocytes and has many physiological roles, including in energy homeostasis. We identified that AM630, a cannabinoid receptor 2 (CB2) antagonist, down-regulated leptin expression in mature adipocytes
Autor:
Tokiko Watanabe, Yoshihiro Kawaoka, Hiroaki Kitano, Kyota Kamiyoshi, Yukiko Matsuoka, Kun-Yi Hsin, Yoshiyuki Asai
Publikováno v:
Nucleic Acids Research
We present systemsDock, a web server for network pharmacology-based prediction and analysis, which permits docking simulation and molecular pathway map for comprehensive characterization of ligand selectivity and interpretation of ligand action on a
Autor:
Daisuke Kobayashi, Attayeb Mohsen, Masakazu Sekijima, Tomoki Ito, M. Michael Gromiha, Masahiro Mochizuki, Mika Sakamoto, Kenji Mizuguchi, Modong Tan, Hideaki Umeyama, Nobuaki Yasuo, Shuntaro Chiba, Shogo Suzuki, Takashi Ishida, Kazuyoshi Ikeda, Daisuke Kihara, Yoshitaka Moriwaki, Yutaka Akiyama, Reiji Teramoto, A. Mary Thangakani, Shintaro Minami, Vipul Gupta, Mitsuo Iwadate, Chioko Nagao, Takaaki Ichikawa, Kazuki Yamamoto, Masahito Ohue, Itsuo Nakane, Kei Yura, Tatsuya Okuno, George Chikenji, Masahiro Kawatani, Kun Yi Hsin, Sakurako Takashina, Takatsugu Hirokawa, Woong-Hee Shin, Devadasan Velmurugan, Hayase Hakariya, Chandrasekaran Ramakrishnan, Ryunosuke Yoshino, Hironori K. Nakamura, Philip Prathipati, Nobuaki Miura, Hiroaki Kitano, Sergey Zozulya, Mari Ito, Akiko Higuchi, Teruki Honma, Petro Borysko, Keita Oda, Anastasiia Gryniukova, Nanako Uchida, Kentaroh Kudoh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library contain
Publikováno v:
Biopharmaceutics & Drug Disposition
Understanding complex biological systems requires the extensive support of computational tools. This is particularly true for systems pharmacology, which aims to understand the action of drugs and their interactions in a systems context. Computationa
Autor:
Hiroaki Kitano, Yuko Tsuchiya, Kun-Yi Hsin, Teruki Honma, Takashi Ishida, Kenji Mizuguchi, Chandrasekaran Ramakrishnan, Devadasan Velmurugan, Masahiro Mochizuki, A. Mary Thangakani, Shuntaro Chiba, Ito Junichi, Keisuke Yanagisawa, Tomohiro Ban, Hideaki Umeyama, Koya Kato, Yutaka Akiyama, George Chikenji, Masakazu Sekijima, Kazuyoshi Ikeda, Y-h. Taguchi, Reiji Teramoto, Nobuaki Yasuo, M. Michael Gromiha, Ryunosuke Yoshino, Tatsuya Okuno, Kazuki Yamamoto, Nobuyoshi Sugaya, Takatsugu Hirokawa, Philip Prathipati, Mitsuo Iwadate
Publikováno v:
Scientific Reports
A search of broader range of chemical space is important for drug discovery. Different methods of computer-aided drug discovery (CADD) are known to propose compounds in different chemical spaces as hit molecules for the same target protein. This stud