Zobrazeno 1 - 10
of 723
pro vyhledávání: '"Kun Xi"'
Autor:
Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang, Kun Xi, Jiamin Guo, Cangsong Shen, Dan-Dan Shen, Pengjun Cai, Qingya Shen, Jieyu Qi, Huibing Zhang, Shao-Kun Zang, Ying-Jun Dong, Luwei Miao, Jiao Qin, Su-Yu Ji, Yue Li, Jianfeng Liu, Chunyou Mao, Yan Zhang, Renjie Chai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is ess
Externí odkaz:
https://doaj.org/article/eda175ba92a2443a9b31648e453755f1
Autor:
Weizhu Huang, Nan Jin, Jia Guo, Cangsong Shen, Chanjuan Xu, Kun Xi, Léo Bonhomme, Robert B. Quast, Dan-Dan Shen, Jiao Qin, Yi-Ru Liu, Yuxuan Song, Yang Gao, Emmanuel Margeat, Philippe Rondard, Jean-Philippe Pin, Yan Zhang, Jianfeng Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex dimeric GPCRs important for the fine tuning of many
Externí odkaz:
https://doaj.org/article/2e27b6adc47142ca827758ef4b87e438
Autor:
Yi‐Bo Zhao, Yuan‐Zhang Jin, Xiao‐Feng Zhao, Xiang‐Dong Lu, De‐Tai Qi, Run‐Tian Zhou, Xiao‐Nan Wang, Hai‐Feng Liu, Liang Chen, Kun Xi, Yang‐Zhang, Tian‐Sheng Sun, Shi‐Qing Feng, Zhi‐Cheng Zhang, Bin Zhao
Publikováno v:
Orthopaedic Surgery, Vol 16, Iss 11, Pp 2633-2643 (2024)
Objective As the population ages and technology advances, lateral lumbar intervertebral fusion (LLIF) is gaining popularity for the treatment of degenerative lumbar scoliosis (DLS). This study investigated the feasibility, minimally invasive concept,
Externí odkaz:
https://doaj.org/article/b885fdb7f1404c669a2033b6ba463650
Autor:
Liang Zhou, Feng Cai, Hongyi Zhu, Yichang Xu, Jincheng Tang, Wei Wang, Ziang Li, Jie Wu, Zhouye Ding, Kun Xi, Liang Chen, Yong Gu
Publikováno v:
Bioactive Materials, Vol 37, Iss , Pp 132-152 (2024)
Sustained and intense inflammation is the pathological basis for intervertebral disc degeneration (IVDD). Effective antagonism or reduction of local inflammatory factors may help regulate the IVDD microenvironment and reshape the extracellular matrix
Externí odkaz:
https://doaj.org/article/e256570324be410ea82d0ff42fbd287d
Autor:
Yang Sun, Jie Wu, Liang Zhou, Wei Wang, Haibo Wang, Shaosong Sun, Yichang Xu, Lichen Zhang, Xinzhao Jiang, Guoqing Zhu, Kun Xi, Yong Gu, Liang Chen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Spinal cord injury (SCI) is associated with microenvironment imbalance, thereby resulting in poor regeneration and recovery of the spinal cord. Gene therapy can be used to balance the inflammatory response, however target genes cannot e
Externí odkaz:
https://doaj.org/article/717dd50cf1fb43c5ae3fd2550b3300e0
Autor:
Ziang Li, Feng Cai, Jincheng Tang, Yichang Xu, Kaijin Guo, Zonghan Xu, Yu Feng, Kun Xi, Yong Gu, Liang Chen
Publikováno v:
Bioactive Materials, Vol 24, Iss , Pp 346-360 (2023)
Intervertebral disc degeneration (IVDD) is commonly caused by imbalanced oxygen metabolism-triggered inflammation. Overcoming the shortcomings of antioxidants in IVDD treatment, including instability and the lack of targeting, remains challenging. Mi
Externí odkaz:
https://doaj.org/article/14b5c98a39a840a89d29854494aa88f6
Autor:
Xinzhao Jiang, Wei Wang, Jincheng Tang, Meng Han, Yichang Xu, Lichen Zhang, Jie Wu, Yiyang Huang, Zhouye Ding, Huiwen Sun, Kun Xi, Yong Gu, Liang Chen
Publikováno v:
Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)
Abstract Although mitochondria are crucial for recovery after spinal cord injury (SCI), therapeutic strategies to modulate mitochondrial metabolic energy to coordinate the immune response and nerve regeneration are lacking. Here, a ligand‐screened
Externí odkaz:
https://doaj.org/article/fcf097b64c21471b827f3620d38ee1ae
Publikováno v:
Defence Technology, Vol 18, Iss 10, Pp 1875-1885 (2022)
This study numerically simulated and investigated the flow field characteristics of a typical dual-pulse solid rocket motor with a soft pulse separation device through thermal insulation ablation under high-temperature dual-pulse erosion. The ablatio
Externí odkaz:
https://doaj.org/article/af73a9d63902407a814945c5604d515b
Publikováno v:
Mathematics, Vol 11, Iss 20, p 4241 (2023)
Printed circuit heat exchangers (PCHEs) are widely used as recuperators in the supercritical carbon dioxide (S-CO2) Brayton cycle design. The variation of heat sources will have a great impact on the heat transfer effect of the recuperator. It is of
Externí odkaz:
https://doaj.org/article/5d1a858387ec4c1cbf719e1a42d82e32
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-5 (2021)
Abstract Background In complex injuries, external fixation device represents a challenge to maintain negative-pressure wound therapy (NPWT). In this trial, we compared a combination of bone wax and colostomy paste versus bone wax alone to seal NPWT a
Externí odkaz:
https://doaj.org/article/c8fef8885b134dbaa1f153b914fc4bfe