Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kun Sang Chang"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94450 (2014)
Promyelocytic leukemia nuclear bodies (PML NBs) are comprised of PML and a striking variety of its associated proteins. Various cellular functions have been attributed to PML NBs, including the regulation of gene expression. We report here that induc
Externí odkaz:
https://doaj.org/article/0081f9dbba40496db1dedc038fb3498d
Autor:
Michael A. Rea, Zhi-Xiang Xu, Zhaoyang Zhao, Anita Van Oort-Jansen, Cheng Chi Lee, Takao Miki, Kun Sang Chang, Mingguang Liu, Misty Chen-Goodspeed
Publikováno v:
The EMBO Journal. 31:1427-1439
Studies have suggested that the clock regulator PER2 is a tumour suppressor. A cancer network involving PER2 raises the possibility that some tumour suppressors are directly involved in the mammalian clock. Here, we show that the tumour suppressor pr
Autor:
Hsiu Ming Shih, Mandar T. Naik, Hong Yi Kuo, Shu-Yu Lin, Kun Sang Chang, Nai-Jia Huang, Yen Sung Huang, Che Chang Chang, Tai Huang Huang, Chiou-Hong Lin, Yung Lin Hsieh, Chun Chen Ho, Ruey-Hwa Chen, Pei Hsin Liao, Nandita M. Naik, Camy C.H. Kung, Jen Chong Jeng
Publikováno v:
Molecular Cell. 42(1):62-74
Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, little is known about the cellular signaling mechanisms that regulate proteins for distinct SUMO paralog conjugatio
Autor:
Hagop M. Kantarjian, Jorge E. Cortes, Nikolay D. Dimov, Farhad Ravandi, Carlos E. Bueso-Ramos, Kun Sang Chang, L. Jeffrey Medeiros
Publikováno v:
Cancer. 116:369-376
BACKGROUND: The authors evaluated the utility of immunofluorescence staining with an antipromyelocytic leukemia (anti-PML) antibody for patients with a suspected diagnosis of new or relapsed acute promyelocytic leukemia (APL) and correlated the findi
Publikováno v:
Molecular Biology of the Cell. 19:3020-3027
Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are dynamic subnuclear compartments that play roles in several cellular processes, including apoptosis, transcriptional regulation, and DNA repair. Histone deacetylase (HDAC) 7 is a potent cor
Autor:
Anthony R. Means, Kun Sang Chang, Hung Ying Kao, Qing Liu, Kristopher J. Stanya, Minh Lam, Erin L. Reineke, Yu Liu
Publikováno v:
Molecular and Cellular Biology. 28:997-1006
Promyelocytic leukemia protein (PML) is an important regulator due to its role in numerous cellular processes including apoptosis, viral infection, senescence, DNA damage repair, and cell cycle regulation. Despite the role of PML in many cellular fun
Autor:
Kun Sang Chang, Gerd G. Maul, Ting Ting Chao, Ding Yen Lin, Jen Chong Jeng, Ming-Jing Hwang, Tong Ping Lin, Yen Sung Huang, Chun Chen Ho, Hsin I. Fang, Hong Yi Kuo, Ching Shu Suen, Hsiu Ming Shih, Chih Chang Hung, Yunching Chen, Che Chang Chang
Publikováno v:
Molecular Cell. 24:341-354
Small ubiquitin-like modifier (SUMO) modification has emerged as an important posttranslational control of protein functions. Daxx, a transcriptional corepressor, was reported to repress the transcriptional potential of several transcription factors
Publikováno v:
Molecular Cell. 17(5):721-732
The promyelocytic leukemia gene (PML), which is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL), encodes a multifunctional protein involved in several important cellular functions. Herein, we demonstrate that
Autor:
Zhi-Xiang Xu, Tian Ding, Thanh T. Tran, Rui Xun Zhao, Kun Sang Chang, Pier Paolo Pandolfi, Wei Zhang
Publikováno v:
Journal of Biological Chemistry. 279:1838-1844
The promyelocytic leukemia protein (PML) plays an essential role in multiple pathways of apoptosis. Our previous study showed that PML enhances tumor necrosis factor-induced apoptosis by inhibiting the NFkappaB survival pathway. To continue exploring
Publikováno v:
Molecular and Cellular Biology. 23:4247-4256
The function of the PML tumor suppressor gene, which encodes a multifunctional protein, is consistently disrupted by t(15;17) in acute promyelocytic leukemia (APL) (26). Promyelocytic leukemia protein (PML) suppresses cell growth (31) and plays an es