Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kun Do Rhee"'
Autor:
Kun Do Rhee
Publikováno v:
Journal of Animal Reproduction and Biotechnology, Vol 38, Iss 1, Pp 2-9 (2023)
Mammalian eyes have a limited ability to regenerate once neurons degenerate. This results in visual impairment that impacts the quality of life among adult populations as well as in young children leading to lifelong consequences. Various therapies a
Externí odkaz:
https://doaj.org/article/1a60d745f0864fb78cce84984bb09ba0
Autor:
Kun Do Rhee, Yanjie Wang, Johanna ten Hoeve, Linsey Stiles, Thao Thi Thu Nguyen, Xiangmei Zhang, Laurent Vergnes, Karen Reue, Orian Shirihai, Dean Bok, Xian-Jie Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal viability and providing insight for the ongoing CNTF clinica
Externí odkaz:
https://doaj.org/article/2f8c15a86a74474882c082f8c3e059f3
Autor:
Kun Do Rhee
Publikováno v:
Journal of Animal Reproduction and Biotechnology, Vol 36, Iss 4, Pp 189-193 (2021)
Jak-STAT pathway is required for embryogenesis, female gametogenesis, cytokine-mediated neuroprotection, diabetes, obesity, cancer, stem cell, and various tissues. The noncanonical role of Jak-STAT in mitochondria function was supported by the detect
Externí odkaz:
https://doaj.org/article/987aaeb144de47f08dc4db2d7a07a7c5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Ciliary neurotrophic factor (CNTF) has been tested in clinical trials for human retinal degeneration due to its potent neuroprotective effects in various animal models. To decipher CNTF-triggered molecular events in the degenerating retina, we perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf91e1894141ace00d4ee4c9a63f678
https://doi.org/10.1038/s41598-020-63519-1
https://doi.org/10.1038/s41598-020-63519-1
Autor:
Kun Do Rhee
Publikováno v:
Journal of Animal Reproduction and Biotechnology. 38:2-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a86dae9c2f724aa7433308d1caf71f4
https://doi.org/10.12750/jarb.38.1.2
https://doi.org/10.12750/jarb.38.1.2
Publikováno v:
Developmental Neuroscience. 26:359-370
Ciliary neurotrophic factor (CNTF) exhibits multiple biological effects during vertebrate retinal development, including regulating the differentiation of photoreceptor cells and promoting the survival and axonal growth of ganglion cells. We report h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b858c46e02a04d202407907b25ceaab
https://doi.org/10.1159/000082278
https://doi.org/10.1159/000082278
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(47)
Ciliary neurotrophic factor (CNTF) acts as a potent neuroprotective agent in multiple retinal degeneration animal models. Recently, CNTF has been evaluated in clinical trials for the inherited degenerative disease retinitis pigmentosa (RP) and for dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c8d873a8e8ae68d8fc6a0eb1e16e62
https://pubmed.ncbi.nlm.nih.gov/24191003
https://pubmed.ncbi.nlm.nih.gov/24191003
Autor:
Kun Do Rhee, Xian-Jie Yang
Publikováno v:
Retinal Degenerative Diseases ISBN: 9781441913982
Ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) exhibit multiple biological effects in the developing vertebrate retina. CNTF/LIF inhibits rod photoreceptor, and promotes bipolar cells and Muller glia differentiation. In addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce7dd29490c49fe0abdbac32456d8d0
https://pubmed.ncbi.nlm.nih.gov/20238069
https://pubmed.ncbi.nlm.nih.gov/20238069
Autor:
Matthew M. LaVail, Alberto Ruiz, Dean Bok, William W. Hauswirth, Xian-Jie Yang, Kun Do Rhee, Jacque L. Duncan
Publikováno v:
Investigative ophthalmologyvisual science. 48(3)
Purpose To characterize molecular and cellular changes induced by sustained expression of ciliary neurotrophic factor (CNTF) in the rds mutant mouse retina. Methods Recombinant adeno-associated virus (rAAV) expressing CNTF was injected subretinally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c21a84c0e39ad49e68300c88d8865e
https://pubmed.ncbi.nlm.nih.gov/17325188
https://pubmed.ncbi.nlm.nih.gov/17325188
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(44)
Ciliary neurotrophic factor (CNTF) exhibits multiple biological effects during vertebrate retinogenesis, including regulation of photoreceptor cell differentiation. In the early postnatal mouse retina, CNTF induces rapid and transient phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4046e48c34d70e167bb1cef8afb39953
https://pubmed.ncbi.nlm.nih.gov/15525763
https://pubmed.ncbi.nlm.nih.gov/15525763