Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kumud Pandav"'
Autor:
Anjana Kumari, Kumud Pandav, Anuradha Panwar, Mala Nath, Rama Krishna Peddinti, Ritu Barthwal
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101324- (2024)
We report interaction of 1,5-Bis (3-morpholinopropionamido) anthracene-9,10-dione with Human Telomeric G4 DNA sequences, wHTel26 and HTel22 in presence of K+ and Na+ ions, respectively. Surface Plasmon Resonance yields association constant Kb = 1.0
Externí odkaz:
https://doaj.org/article/ab261ac9d307487481de42ba8d1bd371
Autor:
Anjana Kumari, Kumud Pandav, Anuradha Panwar, Mala Nath, Rama Krishna Peddinti, Ritu Barthwal
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101148- (2023)
The binding of ligands to G-quadruplex (G4) structures at the ends of human telomeric DNA induces thermal stabilization, which interferes with telomere maintenance by disrupting the association of telomeres with the telomerase enzyme—an important m
Externí odkaz:
https://doaj.org/article/fc03612c417449fa83b0728af39b8fa4
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 648-662 (2022)
G-quadruplex is a non-canonical secondary structure identified in the telomeric region and the promoter of many oncogenes. Anthraquinone derivatives, a well-known inducer of telomere disruption in malignant cells and activate the apoptotic pathway. W
Externí odkaz:
https://doaj.org/article/a8c7b28430004fff95aebe909636ce1f
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 256- (2023)
Externí odkaz:
https://doaj.org/article/a39743f153f84967815b6dbeaff5e2fa
Publikováno v:
ACS Omega, Vol 6, Iss 4, Pp 2613-2625 (2021)
Externí odkaz:
https://doaj.org/article/5bb4d8060c744a0e9f28ebcd2b63f187
Publikováno v:
ACS Omega, Vol 6, Iss 4, Pp 2613-2625 (2021)
ACS Omega
ACS Omega
Binding of Nile Blue (NB) with calf thymus DNA has been studied using molecular modeling, spectroscopic, and thermodynamic techniques. Our study revealed that NB binds to the DNA helix by two types of modes (groove binding and intercalation) simultan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45614b12e03f6c851ad48fa3bac90a91
https://doaj.org/article/5bb4d8060c744a0e9f28ebcd2b63f187
https://doaj.org/article/5bb4d8060c744a0e9f28ebcd2b63f187
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29d9aff09494db9923e3b482c7a8e90
https://doi.org/10.1096/fasebj.2022.36.s1.r2173
https://doi.org/10.1096/fasebj.2022.36.s1.r2173
Publikováno v:
Journal of biomolecular structuredynamics. 39(3)
Anthracycline anticancer drugs show multiple strategies of action on gene functioning by regulation of telomerase enzyme by apoptotic factors, e.g. ceramide level, p53 activity, bcl-2 protein levels, besides inhibiting DNA/RNA synthesis and topoisome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bb7d4308ff04dcc3681902e2fa301e48
https://pubmed.ncbi.nlm.nih.gov/32070245
https://pubmed.ncbi.nlm.nih.gov/32070245
Publikováno v:
Journal of Molecular Recognition. 33
Adriamycin is known to exert its anti cancer action by inhibiting DNA duplication, RNA transcription and topoisomerase-II enzyme action. Recent findings of its binding to G-quadruplex DNA resulting in telomere dysfunction indicated multiple strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca1ed70fb85f1a20f540baf7ca6e685
https://doi.org/10.1002/jmr.2815
https://doi.org/10.1002/jmr.2815
Publikováno v:
Chemico-Biological Interactions. 260:256-262
Harmine, a tricyclic β-carboline alkaloid possesses anticancer properties. Thus, its binding studies with DNA are considerably important because mechanism of action of anticancer drug involves DNA binding. On the other hand, the DNA binding study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c057b78f59725e8ec58efd43de2383
https://doi.org/10.1016/j.cbi.2016.08.025
https://doi.org/10.1016/j.cbi.2016.08.025