Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kumnan Paik"'
Autor:
Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein
Publikováno v:
Experimental Hematology. 27:1746-1756
A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c1a8be21dd8999107c60b154356b0
https://doi.org/10.1016/s0301-472x(99)00118-6
https://doi.org/10.1016/s0301-472x(99)00118-6
Autor:
Yiqing Feng, and Ann M. Donnelly, Joseph O. Polazzi, Edith S. Grabbe, Jeng-Jong Shieh, Barbara Kure Klein, Kumnan Paik, Linda L. Zurfluh, Mark P. Baganoff, John P. McKearn, Charles A. McWherter, William F. Hood, Ann L. Abegg
Publikováno v:
Biochemistry. 38(14)
Myelopoietins (MPOs) are a family of engineered dual interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) receptor agonists that are superior in comparison to the single agonists in their ability to promote the growth and maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d5df240c06e04c290d67fa2c4ff50
https://pubmed.ncbi.nlm.nih.gov/10194378
https://pubmed.ncbi.nlm.nih.gov/10194378
Autor:
William F. Hood, Barbara K. Klein, Yiqing Feng, Charles A. McWherter, Kumnan Paik, John P. McKearn
Publikováno v:
The Journal of biological chemistry. 272(36)
Interleukin-3 (IL-3) is a member of the cytokine superfamily that promotes multi-potential hematopoietic cell growth by interacting with a cell surface receptor composed of alpha and beta chains. The newly available three-dimensional structure of a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00782440e154427e4ced6ec6a5b38ed1
https://pubmed.ncbi.nlm.nih.gov/9278420
https://pubmed.ncbi.nlm.nih.gov/9278420
Autor:
Kumnan Paik, Kris Sterbenz, Barrett R. Thiele, Sarah Ruth Braford-Goldberg, John P. McKearn, Barbara Kure Klein, S. Christopher Bauer, Alan Michael Easton, Peter O. Olins, Joseph O. Polazzi, Jon A. Klover, Maire Helena Caparon
Publikováno v:
The Journal of biological chemistry. 270(40)
A deletion variant of human interleukin-3, hIL-3(15-125), was produced in the periplasmic space of Escherichia coli and had full activity in an AML193.1.3 cell proliferation assay. Libraries of random single-amino acid substitutions were constructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad04817236bc23faf3e9c2e7c961cb
https://pubmed.ncbi.nlm.nih.gov/7559548
https://pubmed.ncbi.nlm.nih.gov/7559548
Autor:
N.R. Staten, Barbara Kure Klein, John Warren Thomas, John P. McKearn, Mark Allen Abrams, Kumnan Paik, Charles M. Baum, William F. Hood, Joseph B. Monahan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(9)
A systematic evaluation of structure-activity information led to the construction of genetically engineered interleukin 3 (IL-3) receptor agonists (synthokines) with enhanced hematopoietic potency. SC-55494, the most extensively characterized member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f235d31e6f8386760644b0e44c672b8
https://pubmed.ncbi.nlm.nih.gov/7537376
https://pubmed.ncbi.nlm.nih.gov/7537376