Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kumio Okaichi"'
Autor:
Tomomi Kurashige, Hisayoshi Kondo, Shiro Miura, Mutsumi Matsuu-Matsuyama, Masahiro Nakashima, Kumio Okaichi, Kazuko Shichijo
Publikováno v:
Journal of Radiation Research
Exposure to ionizing radiation during childhood is a well-known risk factor for thyroid cancer. Our study evaluated the effect of age on the radiosensitivity of rat thyroid glands. Four-week-old (4W), 7 -week-old (7W), and 8-month-old (8M) male Wista
Autor:
Masahiro Nakashima, Toshiyuki Nakayama, Ichiro Sekine, Kumio Okaichi, Kazuko Shichijo, Mutsumi Matsuu-Matsuyama
Publikováno v:
Journal of Radiation Research. 52(3):369-373
We previously reported that the apoptosis index in jejunal crypt cells after X irradiation was greater in spontaneously hypertensive rats than in Wistar-Kyoto rats. Moreover, these same cells showed a suppression of apoptosis when reserpine was admin
Autor:
Mutsumi Matsuu-Matsuyama, Kumio Okaichi, Kazuko Shichijo, Masahiro Nakashima, Ichiro Sekine, Toshiyuki Nakayama
Publikováno v:
Radiation Research. 174:52-61
The effect of basic fibroblast growth factor (bFGF) was studied in radiation-induced apoptosis in rat jejunal crypt cells. Six-week-old male Wistar rats were administered 4 mg/kg bFGF intraperitoneally 25 h before receiving 8 Gy whole-body X rays. Th
Autor:
Kumio Okaichi, Masahiro Nakashima, Kazuko Shichijo, Mutsumi Matsuu-Matsuyama, Ichiro Sekine, Takashi Uemura, Daisuke Niino, Toshiyuki Nakayama
Publikováno v:
Journal of Radiation Research. 49:341-347
Polaprezinc, an anti-ulcer drug, is a chelate compound consisting of zinc and L-carnosine. Polaprezinc has been shown to prevent gastric mucosal injury. The anti ulcer effects of polaprezinc have been ascribed to its antioxidative property. The effec
Autor:
Li-Hong Wang, Masami Watanabe, Yutaka Okumura, Masahiro Yoshida, Kumio Okaichi, Miwa Horikawa, Naoki Matsuda
Publikováno v:
Photochemistry and Photobiology. 72:334-339
The mechanisms by which mitogen-activated protein kinases (MAPK) respond to the input of UV-induced signal transduction pathways and the resulting biological functions are not well understood. We investigated whether the level of oxygen tension of cu
Autor:
Kumio Okaichi, Masahiro Nakashima, Kazuko Shichijo, Ichiro Sekine, Mutsumi Matsuu-Matsuyama, Kouji Ishii, Yutaka Okumura, Chung Yang Wen, Toshiyuki Nakayama, Eiichiro Fukuda
Publikováno v:
Journal of Radiation Research. 47:1-8
Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate o
Publikováno v:
International Congress Series. 1258:239-243
Mutation of the p53 gene is the most common genetic alteration observed in human cancers. It has been widely reported that cells with mutant p53 change radiation sensitivity. The specific mutations were not discussed in these reports. Radiation sensi
Autor:
Toshiyuki Nakayama, Masahiro Nakashima, Mutsumi Matsuu, Sennosuke Tokumaru, Sanetaka Shirahata, Chun Yang Wen, Kumio Okaichi, Ichiro Sekine, Kazuko Shichijo, Eiichiro Fukuda
Publikováno v:
Journal of Radiation Research. 44:111-115
To evaluate the effect of fermented milk kefir on X-ray-induced apoptosis in the colon of rats, we examined the apoptotic index, the mean number of apoptotic cells detected by H&E staining per crypt in the colon, in control rats and kefir-pretreated
Publikováno v:
Journal of radiation research. 43:261-264
To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20
Autor:
Megumi Ikeda, Naoki Matsuda, Naoko Morita, Haruki Takahashi, Masami Watanabe, Yutaka Okumura, Keiji Suzuki, Kumio Okaichi
Publikováno v:
International Congress Series. 1236:359-362
Wortmannin is an inhibitor of PI3-kinase and acts on cultured cells at doses below 1 μM. Wortmannin also inhibits the PI3-kinase family such as ATM or DNA-PK at doses above 10 μM. There are many reports on the enhancement of cell radiosensitivity b