Výsledky vyhledávání - "Kumiko Tokuda"

Structural insight into receptor-selectivity for lurasidone

Autor: Tomoko Horisawa, Kumiko Tokuda, Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Kazuto Yamazaki, Megumi Maruyama, Ryu Nagata

Publikováno v: Neurochemistry International. 61:1133-1143

Lurasidone is a novel antipsychotic agent with high affinity for dopamine D(2), 5-hydroxyltryptamine 5-HT(2A), and 5-HT(7) receptors. Lurasidone has negligible affinity for histamine H(1) and muscarinic M(1) receptors, which are thought to contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167b39123352b2e47c94d2c8dc8a1c1
https://doi.org/10.1016/j.neuint.2012.08.005

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Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats

Autor: Takeo Ishiyama, Kumiko Tokuda, Akira Ito, Satoko Toma, Takeshi Enomoto, Tadashi Ishibashi

Publikováno v: Behavioural Brain Research. 186:197-207

We have previously shown that lurasidone, a novel atypical antipsychotic, potently reverses learning impairment induced by the N-methyl- d -aspartate receptor antagonist MK-801 in the rat passive avoidance test. However, the effects of lurasidone in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6898d5a6086e4a532486ac8ab9ef46b8
https://doi.org/10.1016/j.bbr.2007.08.012

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Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test

Autor: Tadashi Ishibashi, Kumiko Tokuda, Satoko Toma, Takeo Ishiyama, Yukihiro Ohno, Akira Ito

Publikováno v: European Journal of Pharmacology. 572:160-170

Lurasidone (SM-13496) is a novel atypical antipsychotic with high affinities to dopamine D2, serotonin 5-HT7, 5-HT2A, 5-HT1A receptors and α2C adrenoceptor. In this study, the effects of lurasidone on the rat passive-avoidance response and its impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad9796434c4b499c7e004bcbcd86c66
https://doi.org/10.1016/j.ejphar.2007.06.058

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Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity

Autor: Satoko Toma, Yoko Ueda, Yukihiro Ohno, Kumiko Tokuda, Hitomi Oki, Kenji Matsumoto, Takeo Ishiyama, Tomoko Horisawa, Hiroyuki Nishikawa, Tadashi Ishibashi, Mitsutaka Nakamura, Norihiko Tanno, Masaaki Ogasa, Ikutaro Saji, Akira Ito, Rie Tagashira

Publikováno v: The Journal of pharmacology and experimental therapeutics. 334(1)

Lurasidone [(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b1922595812986a6a0070c9ba11828
https://pubmed.ncbi.nlm.nih.gov/20404009

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1053 – In vitro receptor-binding profile of lurasidone and other commonly-used antipsychotics

Autor: Stephen M. Stahl, Kumiko Tokuda, P. Werner, Josephine Cucchiaro, Takeo Ishiyama, M. Ogasa, Tadashi Ishibashi, Tomoko Horisawa, Antony Loebel

Publikováno v: European Psychiatry. 28:1

Introduction Atypical antipsychotics bind to multiple receptor types and subtypes. Improved outcomes in schizophrenia are linked to activity at D2 and serotonin receptors 5-HT7, 5-HT2A and 5-HT1A. Objectives To characterize the receptor-binding profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2741e518f9be43d6d6c3566703fac76a
https://doi.org/10.1016/s0924-9338(13)76173-x

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