Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kumiko SHIONO"'
Publikováno v:
Journal of Pharmacobio-Dynamics. 3:1-10
Antihypertensive effects of three beta-adrenergic blocking drugs, acebutolol, propranolol, and practolol were studied for 11 weeks. Spontaneously (SHR); one-clip, two-kidney (CLIP); and deoxycorticosterone and salt (DOC) hypertensive rats were used.
Publikováno v:
Japanese Heart Journal. 19:886-894
The F1 hybrids (F1) of spontaneously hypertensive rats (SHR) and Wistar rats (W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks, showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation
Publikováno v:
British Journal of Clinical Pharmacology. 20:7S-22S
The haemodynamic, antianginal and antihypertensive effects of nicardipine, a vascular selective calcium antagonist, were studied in experimental animals. In the canine isolated coronary artery, nicardipine relaxed potassium-induced contraction and su
Publikováno v:
Japanese Heart Journal. 17:768-773
Utilizing the microsurgical method of transplantation in the rat, the role of the kidney in an experimental renal hypertension due to segmental renal infarction was studied. When the infarcted kidney was transplanted into the bilaterally nephrectomiz
Publikováno v:
Japanese Journal of Pharmacology. 38:31-41
The autonomic and antihypertensive activities of amosulalol (YM-09538) were studied in conscious rats. Single oral administration of amosulalol antagonized the phenylephrine-induced pressor and isoproterenol-induced positive chronotropic responses wi
Autor:
Zen-ichi HENMI, Daijiro HORII, Takashi MITHUSHIMA, Hiroshi KAWAZURA, Hitoshi HAYASHI, Motokuni MORI, Nobuyuki SANO, Sadahiro SHIMIZU, Kazutoshi HORIKOMI, Kumiko SHIONO
Publikováno v:
Folia Pharmacologica Japonica. 68:102-113
Effects of a new analgesic drug, K-315, on the central nervous system were investigated electro-encephalographically and neurophpsiologically. Results are as follows: 1. K-315 slightly synchronized spontaneous EEG, and inhibitory actions of arousal r
Publikováno v:
Folia Pharmacologica Japonica. 67:564-571
Publikováno v:
Japanese heart journal. 19(4)
Publikováno v:
Japanese journal of pharmacology. 28(3)
3-Hydrazino-6-[N, N-bis (2-hydroxyethyl)amino]-pyridazine (L 6150) has been reported as an antihypertensive vasodilator drug. We determined antihypertensive effect of L 6150 for 11 weeks in spontaneously hypertensive (SHR) rats, deoxycorticosterone a
Publikováno v:
Clinical and experimental hypertension. Part A, Theory and practice. 4(1-2)
Studies on the structure-activity relationship using 9 new 3-sulfamoylphenylethylamines revealed that YM-09538, YM-09649 and YM-09686 were competitive antagonists at both beta- and post-synaptic alpha-receptors. The following order of adrenoceptor bl