Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kumiko Nishiyama"'
Autor:
Tsutomu Sasaki, Sunao Hisada, Hideaki Kanki, Kazuto Nunomura, Bangzhong Lin, Kumiko Nishiyama, Tomohito Kawano, Shigenobu Matsumura, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Calcium oscillations in primary neuronal cultures and iPSCs have been employed to investigate arrhythmogenicity and epileptogenicity in drug development. Previous studies have demonstrated that Ca2+ influx via NMDA and nicotinic acetylcholin
Externí odkaz:
https://doaj.org/article/9b6e3447e8e248359c5367162194bbbc
Autor:
Shintaro Sugiyama, Tsutomu Sasaki, Hiroo Tanaka, Haomin Yan, Takeshi Ikegami, Hideaki Kanki, Kumiko Nishiyama, Goichi Beck, Yasufumi Gon, Shuhei Okazaki, Kenichi Todo, Atsushi Tamura, Sachiko Tsukita, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Blood–brain barrier (BBB) disruption contributes to brain injury and neurological impairment. Tight junctions (TJs) and cell–cell adhesion complexes develop between endothelial cells in the brain to establish and maintain the BBB. Occlud
Externí odkaz:
https://doaj.org/article/41678653a17c4fecad0c010b521563ea
Autor:
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, Akiko Nakata, Minoru Yoshida, Shinichi Uesato, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation. But Mdmx dynamics in ce
Externí odkaz:
https://doaj.org/article/d535ef55554745bdb1de765b94ef736c
Autor:
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)
Background Immune cells play a vital role in the pathology of ischemic stroke. Neutrophils and polymorphonuclear myeloid‐derived suppressor cells share a similar phenotype and have attracted increasing attention in immune regulation research, yet t
Externí odkaz:
https://doaj.org/article/a8a324306f5f4ac28e2ff7c41744bf5a
Autor:
Haomin Yan, Hideaki Kanki, Shigenobu Matsumura, Tomohiro Kawano, Kumiko Nishiyama, Shintaro Sugiyama, Hiroshi Takemori, Hideki Mochizuki, Tsutomu Sasaki
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract MicroRNA-132/212 has been supposed as a critical gene related to the blood–brain barrier (BBB) protection after stroke, but its regulation pathway including the upstream regulator and downstream targets is still unclear. Herein, we demonst
Externí odkaz:
https://doaj.org/article/d799c81967074f7c8519cf4b72acf2e6
Publikováno v:
Evolutionary Psychology, Vol 13 (2015)
Humans have engaged in unique cooperative breeding insofar as multiple in-group members help mothers. Two psychological-proximate factors maintain such a breeding system—various individuals' interest in infants and mothers' positive reactions towar
Externí odkaz:
https://doaj.org/article/91f61614854a4559a9fedc4d08c4ae80
Autor:
Satoshi Obika, Takanori Yokota, Hiroshi Tsuda, Takuya Uehara, Chi-Jing Choong, Kousuke Baba, Hideki Hayakawa, Yuuya Kasahara, Tetsuya Nagata, Hideki Mochizuki, Kumiko Nishiyama, Masayuki Nakamori
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. A characteristic pathological feature of PD is cytoplasmic accumulation of α-synuclein (SNCA) protein. Multiplication of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba4d55fb2f2c7593ab0e3651b59ad83
http://link.springer.com/article/10.1038/s41598-019-43772-9
http://link.springer.com/article/10.1038/s41598-019-43772-9
Autor:
Kenichi Todo, Hiroshi Takemori, Kumiko Nishiyama, Tomohiro Kawano, Shigenobu Matsumura, Hideaki Kanki, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
Publikováno v:
J Neurosci
The cAMP pathway is known to stabilize endothelial barrier function and maintain vascular physiology. The family of cAMP-response element binding (CREB)-regulated transcription coactivators (CRTC)1–3 activate transcription by targeting the basic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07711f01994e164bdaf9de8884024ca
https://europepmc.org/articles/PMC7724130/
https://europepmc.org/articles/PMC7724130/
Autor:
Chi-Jing Choong, Hideaki Kanki, Genki Kubo, Masahiko Taniguchi, Ayana Hotei, Kumiko Nishiyama, Hideki Mochizuki, Yoshiyuki Hirata, Shinichi Uesato, Tsutomu Sasaki
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
We previously synthesized new 5-thienyl-substituted 2-aminobenzamide-type HDAC1, 2 inhibitors with the (4-ethyl-2,3-dioxopiperazine-1-carboxamido) methyl group. K-560 (1a) protected against neuronal cell death in a Parkinson’s disease model by up-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c103f80ca532afea7b70181744d893f
http://link.springer.com/article/10.1038/s41598-018-19664-9
http://link.springer.com/article/10.1038/s41598-018-19664-9
Publikováno v:
Diabetology International. 6:219-225
Levels of hemoglobin A1c (HbA1c) in patients under hemodialysis (HD) show lower values than expected based on plasma glucose levels, and they fluctuate according to changes in the weekly dosage of erythropoiesis-stimulating agent (ESA) administered f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bd766a40997423c81ca113cd3e63232
https://doi.org/10.1007/s13340-014-0191-x
https://doi.org/10.1007/s13340-014-0191-x