Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kumiko Iwabuchi"'
Autor:
Kumiko Iwabuchi, Akihiro Kagita, Lucy F. Yang, Nanako Shirai, Takahiro Iguchi, Yoko Fujita, Jun Komano, Takeshi Noda, Akitsu Hotta, Noriko Sasakawa, Yukimasa Makita, Matthew A. Waller, Naoto Inukai, Peter Gee, Mio Iwasaki, Mandy S. Y. Lung, Hidetoshi Sakurai, Yasuko O. Abe, Xiou H. Wang, Yasutomo Miura, Kei Watanabe, Masahiko Yasuda, Hiroyuki Hozumi, Huaigeng Xu, Yuya Okuzaki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may cause off-target mutagenesis and immunogenicity. Thus, a transient delivery system is needed for therapeutic genome editing applications. Here, we develop an extracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee31e2e65e6f5c8105713123b385118
http://hdl.handle.net/2433/259354
http://hdl.handle.net/2433/259354
Publikováno v:
Methods in Molecular Biology ISBN: 9781493986507
Duchenne muscular dystrophy (DMD) is a congenital X-linked disease caused by mutations in the gene encoding the dystrophin protein, which is required for myofiber integrity. Exon skipping therapy is an emerging strategy for restoring the open reading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cfd3da4e4cfc7beb8e69cc781f7b7a7
https://doi.org/10.1007/978-1-4939-8651-4_12
https://doi.org/10.1007/978-1-4939-8651-4_12
Autor:
Anna Johnsson, Tyson Ruetz, Sten Linnarsson, Stavroula Skylaki, Eleni Chantzoura, Kumiko Iwabuchi, Keisuke Kaji, James O’Malley, Simon R. Tomlinson
Publikováno v:
Nature
O'Malley, J, Skylaki, S, Iwabuchi, K A, Chantzoura, E, Ruetz, T, Johnsson, A, Tomlinson, S R, Linnarsson, S & Kaji, K 2013, ' High-resolution analysis with novel cell-surface markers identifies routes to iPS cells ', Nature, vol. 499, no. 7456, pp. 88-91 . https://doi.org/10.1038/nature12243
O'Malley, J, Skylaki, S, Iwabuchi, K A, Chantzoura, E, Ruetz, T, Johnsson, A, Tomlinson, S R, Linnarsson, S & Kaji, K 2013, ' High-resolution analysis with novel cell-surface markers identifies routes to iPS cells ', Nature, vol. 499, no. 7456, pp. 88-91 . https://doi.org/10.1038/nature12243
The generation of induced pluripotent stem (iPS) cells presents a challenge to normal developmental processes. The low efficiency and heterogeneity of most methods have hindered understanding of the precise molecular mechanisms promoting, and roadblo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3cd44aa15a3d49401a90342568ebd7
http://europepmc.org/articles/PMC3743022
http://europepmc.org/articles/PMC3743022
Publikováno v:
Scientific Reports
The hexose transporter, GLUT2 (SLC2A2), which is expressed by mouse embryos, is important for survival before embryonic day 10.5, but its function in embryos is unknown. GLUT2 can transport the amino sugar glucosamine (GlcN), which could increase sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f395a0aacb401847eb4364ebfd829899
https://pubmed.ncbi.nlm.nih.gov/27311888
https://pubmed.ncbi.nlm.nih.gov/27311888
Autor:
Yi Zhang, Xiaoji Wu, Atsuo Ogura, Kumiko Iwabuchi, Falong Lu, Huihan Wang, William H. Press, Li Shen, Shogo Matoba, Lin Yang, Jeannie T. Lee, Kimiko Inoue, Lan Jiang
Publikováno v:
Cell Stem Cell. 23:343-354.e5
Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and abnormal Xist activation as epigenetic barriers that impede SCNT. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7df1f84c73f6b749f020a11a49fa9f
https://doi.org/10.1016/j.stem.2018.06.008
https://doi.org/10.1016/j.stem.2018.06.008
Autor:
Kumiko Iwabuchi, Tatsuya Yamakawa, Keisuke Okita, Kazutoshi Takahashi, Tomoko Ichisaka, Shinya Yamanaka, Yoshiko Sato
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20461 (2011)
PLoS ONE
PLoS ONE
The principal factors that lead to proliferation and pluripotency in embryonic stem cells (ESCs) have been vigorously investigated. However, the global network of factors and their full signaling cascade is still unclear. In this study, we found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80857d08e8143737624a9224e083cc83
https://doi.org/10.1371/journal.pone.0020461
https://doi.org/10.1371/journal.pone.0020461
Autor:
Kyoko Miura, Kumiko Iwabuchi, Takashi Shinohara, Masato Nakagawa, Tomoko Ichisaka, Masanori Imamura, Shinya Yamanaka, Mito Kanatsu-Shinohara, Jiyoung Lee
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 6, Iss 1, p 34 (2006)
BMC Developmental Biology, Vol 6, Iss 1, p 34 (2006)
BackgroundWe previously identified a set of genes called ECATs (ES cell-associated transcripts) that are expressed at high levels in mouse ES cells. Here, we examine the expression and DNA methylation of ECATs in somatic cells and germ cells.ResultsI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24060918cf60fcaf759644f5590f73f0
http://europepmc.org/articles/PMC1564388
http://europepmc.org/articles/PMC1564388
Publikováno v:
Cell. (4):884-895
SummaryMammalian oocytes can reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT embryos fail to develop to term due to undefined reprogramming defects. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8211d5047f17b1f66a13c18951f50dd6