Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Kumiko Ishige"'
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Kosuke Sugawa, Yoshihisa Ito, Kumiko Ishige
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 64-71 (2017)
Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Although recent studies have shown that PGE2 induces cell differentiation in some neuronal cells such as mouse DRG neurons and sensory neuron-like
Externí odkaz:
https://doaj.org/article/191ccc3a1bf24d9588cb3081d54d24ac
Autor:
Toru Imai, Yasuhiro Kosuge, Hiroaki Saito, Taketo Uchiyama, Taira Wada, Shigeki Shimba, Kumiko Ishige, Shinichi Miyairi, Makoto Makishima, Yoshihisa Ito
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 3, Pp 185-188 (2016)
S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds te
Externí odkaz:
https://doaj.org/article/568f1a7fa0974caa9c6caba7e43c695a
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Masaki Sato, Yoshiyuki Shibukawa, Yuri Aono, Tadashi Saigusa, Yoshihisa Ito, Kumiko Ishige
Publikováno v:
Cells, Vol 9, Iss 7, p 1741 (2020)
Motor neuron diseases are a group of progressive neurological disorders that degenerate motor neurons. The neuroblastoma × spinal cord hybrid cell line NSC-34 is widely used as an experimental model in studies of motor neuron diseases. However, the
Externí odkaz:
https://doaj.org/article/c607fb91387b4bb09e21ffdbe7e38dfe
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Nana Yoshimura, Hiroko Miyagishi, Takanori Kanazawa, Kaname Hashizaki, Toyofumi Suzuki, Kumiko Ishige
Publikováno v:
Cells, Vol 9, Iss 4, p 934 (2020)
Prostaglandins are a group of physiologically active lipid compounds derived from arachidonic acid. Our previous study has found that prostaglandin E2 promotes neurite outgrowth in NSC-34 cells, which are a model for motor neuron development. However
Externí odkaz:
https://doaj.org/article/bda67fc87856413f85c164abded13a7f
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 4, Pp 251-256 (2013)
Mithramycin A (MTM) has been shown to inhibit cancer growth by blocking the binding of Sp-family transcription factors to gene regulatory elements and is used for the treatment of leukemia and testicular cancer in the United States. In contrast, MTM
Externí odkaz:
https://doaj.org/article/80893a6683074fb3849a6fb678bc2512
Autor:
Hiroko Miyagishi, Yasuhiro Kosuge, Yuki Yoneoka, Maiko Ozone, Manami Endo, Nobuhiro Osada, Kumiko Ishige, Kuniko Kusama-Eguchi, Yoshihisa Ito
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 347-350 (2013)
Abstract.: Prostaglandin E2 (PGE2) was shown to induce neuronal death in the CNS. To characterize the neurotoxicity of PGE2 and E-prostanoid receptors (EP) in motor neurons, we investigated PGE2-induced cell death and the type(s) of EP responsible fo
Externí odkaz:
https://doaj.org/article/fdbaf0e72e82462baa8525f752806747
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 225-236 (2012)
Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still r
Externí odkaz:
https://doaj.org/article/2ff9e93bd0714ef2a2f0a481e8badb2d
Autor:
Taira Wada, Yuya Ichihashi, Emi Suzuki, Yasuhiro Kosuge, Kumiko Ishige, Taketo Uchiyama, Makoto Makishima, Reiko Nakao, Katsutaka Oishi, Shigeki Shimba
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2813 (2018)
Brain and muscle arnt-like protein 1 (BMAL1), is a transcription factor known to regulate circadian rhythm. BMAL1 was originally characterized by its high expression in the skeletal muscle. Since the skeletal muscle is the dominant organ system in en
Externí odkaz:
https://doaj.org/article/26937503200449ec8a34d8c7150d999b
Autor:
Saori Shimada, Mioko Hirabayashi, Kumiko Ishige, Yasuhiro Kosuge, Tetsuro Kihara, Yoshihisa Ito
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 2, Pp 217-224 (2010)
Several reports have shown that some dopamine receptor ligands modulate the ischemia–reperfusion injury in animal models; however, its underling mechanisms are still unclear. In this study, we sought to establish an in vitro experimental model of h
Externí odkaz:
https://doaj.org/article/8f47368674fc4283a786718586db050e
Autor:
Kumiko Ishige, Noritaka Takagi, Toru Imai, Wolf Dieter Rausch, Yasuhiro Kosuge, Tetsuroh Kihara, Kuniko Kusama-Eguchi, Hiroko Ikeda, Alexander Rudolf Cools, John Lionel Waddington, Noriaki Koshikawa, Yoshihisa Ito
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 1, Pp 46-55 (2007)
Amyloid β (Aβ) toxicity has been implicated in cell death in the hippocampus, but its specific mechanisms are poorly understood. In this study, Aβ-induced cell death was investigated in organotypic hippocampal slice cultures (OHCs) that were cultu
Externí odkaz:
https://doaj.org/article/13076b1bb6ce477194425d87dc87c474