Výsledky vyhledávání - "Kumiko Hirai"

Spatial transcriptome of developmental mouse brain reveals temporal dynamics of gene expressions and heterogeneity of the claustrum

Autor: Yuichiro Hara, Takuma Kumamoto, Naoko Yoshizawa-Sugata, Kumiko Hirai, Song Xianghe, Hideya Kawaji, Chiaki Ohtaka-Maruyama

During the development of the mammalian cerebral cortex, numerous neurons are arranged in a six-layer structure with an inside-out fashion to form the neocortex and wire neural circuits. This process includes cell proliferation, differentiation, migr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa669c8d653f01da1a9a140aecf6b663
https://doi.org/10.1101/2023.04.12.536360

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ADAMTS2 regulates radial neuronal migration by activating TGF-β signaling at the subplate layer of the developing neocortex

Autor: Noe Kaneko, Kumiko Hirai, Minori Oshima, Kei Yura, Mitsuharu Hattori, Nobuaki Maeda, Chiaki Ohtaka-Maruyama

During the development of the mammalian brain, neocortical structures are formed by the sequential radial migration of newborn excitatory neurons. The early migrating neurons exhibit a multipolar shape, but they undergo a multipolar-to-bipolar transi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44dec666fd1ec9c4d3d6b00a2e967e18
https://doi.org/10.1101/2022.08.07.502954

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Dual role of the carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase: mitochondrial-targeting signal and enzymatic activity

Autor: Kuniaki Saito, Tomihiko Uemura, Seiich Haga, Kumiko Hirai, Susumu Izumi, Hidehito Kuroyanagi, Yoshitaka Tatebayashi, Yoshitaka Hayashi, Kanako Hirabayashi-Takahashi

Publikováno v: Journal of Biochemistry. 148:639-650

L-kynurenine 3-monooxygenase (KMO) is an NAD(P)H-dependent flavin monooxygenase that catalyses the hydroxylation of L -kynurenine to 3-hydroxykynurenine, and is localized as an oligomer in the mitochondrial outer membrane. In the human brain, KMO may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6024587e90168101b7fb4b3d9524a4a2
https://doi.org/10.1093/jb/mvq099

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L-kynurenine 3-monooxygenase from mitochondrial outer membrane of pig liver: purification, some properties, and monoclonal antibodies directed to the enzyme

Autor: Kumiko Hirai, Tomihiko Uemura

Publikováno v: Journal of biochemistry. 123(2)

We have purified L-kynurenine 3-monooxygenase from pig liver mitochondria using a procedure involving seven steps composed of (1) preparation of mitochondrial outer membrane, (2) preparation of the zwitterionic detergent, 3-[(3-cholamidopropyl)dimeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972f81abc2b3a8bc57fba48b215108f2
https://pubmed.ncbi.nlm.nih.gov/9538200

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Localization of serotonin immunoreactivity in cephalopod visual system

Autor: Kumiko Hirai, Chie Haga, Kenji Kosaka, Tsuyako Kito-Yamashita, Tomihiko Uemura, Hiromi Kondo

Publikováno v: Brain research. 521(1-2)

The distribution of 5-HT-like immunoreactivity in paraformaldehyde-fixed sections of retina, optic nerve and the optic lobe of Octopus vulgaris was studied by both immunofluorescence and avidin-biotin complex (ABC) immunohistochemical methods utilizi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5b4eece2e73d760ec90fc82b7e4f3b
https://pubmed.ncbi.nlm.nih.gov/2207679

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Isolation, structure, and properties of the beta-carboline formed from 5-hydroxytryptamine by the superoxide anion-generating system

Autor: Masaru Kanashiro, Tomihiko Uemura, Toshio Yamano, Noriyuki Miyazaki, Kumiko Hirai

Publikováno v: Journal of neurochemistry. 51(3)

A yellow substance was isolated by Sephadex LH-20 gel chromatography, silica gel TLC, and reversed-phase HPLC after incubation of 5-hydroxytryptamine (5-HT) with the superoxide anion (O2-)-generating system, i.e., the xanthine-xanthine oxidase system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdecb2ab33ed0ef699e2e98538b7b1a6
https://pubmed.ncbi.nlm.nih.gov/2842454

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