Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kumi Shoji"'
Publikováno v:
Kidney International Supplements
Chronic kidney disease (CKD) is placing an increasing burden on patients and societies because no decisive therapy has been established. Tubulointerstitial lesions accompanied by fibrosis, inflammatory cells, and capillary rarefaction not only charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fb20746ad2afd1aca91ba37ca92207
http://europepmc.org/articles/PMC4220514
http://europepmc.org/articles/PMC4220514
Autor:
Takehiko Wada, Eri Muso, Tomomi Endo, Kouju Kamata, Masaomi Nangaku, Sawako Kato, Takao Saito, Yoko Obata, Kumi Shoji, Hideki Kato, Enyu Imai, Seiichi Matsuo, Keiji Fujimoto, Yoshie Sasatomi, Shoichi Maruyama, Tomoya Nishino, Shunya Uchida, Hitoshi Yokoyama
Publikováno v:
Kidney International. 85:641-648
Elevated serum-soluble urokinase receptor (suPAR) levels have been described in patients with focal segmental glomerulosclerosis (FSGS) in several different cohorts. However, it remains unclear whether this is the case for Japanese patients and wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0233a3a1d07a7f3fcd81f5cfdda4786c
https://doi.org/10.1038/ki.2013.544
https://doi.org/10.1038/ki.2013.544
Publikováno v:
Current Opinion in Nephrology and Hypertension. 23:161-168
Chronic hypoxia in the tubulointerstitium has been recognized as a final common pathway that leads to the development of end-stage renal disease. Hypoxia-inducible factor (HIF), a master regulator of the adaptive response against hypoxia, is involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4d2b7151124e39d71b301c38618ba3
https://doi.org/10.1097/01.mnh.0000441049.98664.6c
https://doi.org/10.1097/01.mnh.0000441049.98664.6c
Publikováno v:
Current Pathobiology Reports. 1:283-289
Various extrinsic stresses, including hypoxia and oxidative stress, trigger the progression of diseases associated with inflammation and fibrosis via the pathogenic alteration of these stress signals. They include the HIF pathway, induced by hypoxia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6891800c2f8a1be4275de447a22ebae3
https://doi.org/10.1007/s40139-013-0029-4
https://doi.org/10.1007/s40139-013-0029-4
Publikováno v:
Journal of Biological Chemistry. 287:34866-34882
Anthracycline chemotherapeutic agents of the topoisomerase inhibitor family are widely used for the treatment of various tumors. Although targeted tumor tissues are generally situated in a hypoxic environment, the connection between efficacy of anthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4311d82a046638e95f48ba105dd15ce3
https://doi.org/10.1074/jbc.m112.374587
https://doi.org/10.1074/jbc.m112.374587
Autor:
Kazunori Nagasaka, Kumi Shoji, Michihiro Tanikawa, Yuji Ikeda, Haruko Hiraike, Satoshi Koyama, Katsutoshi Oda, Hiroshi Fukuhara, Yu Matsumoto, Kenbun Sone, Tetsu Yano, Keiichi Nakagawa, Akira Shirane, Yuji Taketani, Yuichiro Miyamoto, Shunsuke Nakagawa, Osamu Wada-Hiraike, Tetsushi Tsuruga, Shigeaki Kato
Publikováno v:
British Journal of Cancer
Background: The TFII-I is a multifunctional transcriptional factor known to bind specifically to several DNA sequence elements and to mediate growth factor signalling. A microdeletion at the chromosomal location 7q11.23 encoding TFII-I and the relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d2798970355ea1d535b15f2f48c833
https://doi.org/10.1038/bjc.2011.75
https://doi.org/10.1038/bjc.2011.75
Autor:
Toshiro Fujita, Kohei Ueda, Kenjiro Honda, Akihiro Tojo, Nobuhiro Ayuzawa, Takamoto Ohse, George Seki, Hirotsugu Suto, Kumi Shoji
Publikováno v:
Nihon Toseki Igakkai Zasshi. 44:455-461
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5469752fa52d9a050b55a65d010344d1
https://doi.org/10.4009/jsdt.44.455
https://doi.org/10.4009/jsdt.44.455
Autor:
Kenbun Sone, Kumi Shoji, Kazunori Nagasaka, S Saji, Yu Matsumoto, Haruko Hiraike, Michihiro Tanikawa, Keiichi Nakagawa, Shunsuke Nakagawa, Shigeaki Kato, Hiroshi Fukuhara, Tetsushi Tsuruga, Yuji Taketani, Katsutoshi Oda, Tetsu Yano, Satoshi Koyama, Yuichiro Miyamoto, Osamu Wada-Hiraike
Publikováno v:
British Journal of Cancer
The gene encoding DBC1 (deleted in breast cancer 1) was identified during a representative differential analysis to search for candidate breast tumour-suppressor genes on a human chromosome 8p21 region that is frequently deleted in breast cancers (Ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcc72b6969f4bb2dce3e8f6056fca28
https://doi.org/10.1038/sj.bjc.6605577
https://doi.org/10.1038/sj.bjc.6605577
Autor:
Satsuki Murayama-Hosokawa, Shinzo Yamamoto, Katsutoshi Oda, Tetsu Yano, Yuriko Uehara, Masahi Fukayama, Shumpei Ishikawa, Frank McCormick, Yuji Taketani, Hiroyuki Aburatani, Shunsuke Nakagawa, Yasuhiro Ikeda, Kumi Shoji
Publikováno v:
Oncogene. 29:1897-1908
Endometrial cancer is one of the tumor types in which either chromosomal instability (CIN) or microsatellite instability (MSI) may occur. It is known to possess mutations frequently in the Ras-PI3K (phosphatidylinositol 3'-kinase) pathway. We perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34a615ed3186d322fe1de67b4a7347d
https://doi.org/10.1038/onc.2009.474
https://doi.org/10.1038/onc.2009.474
Autor:
Kenbun Sone, Hiroyuki Kuramoto, Katsutoshi Oda, S Hosokawa, Tetsu Yano, Shunsuke Nakagawa, Kei Kawana, Yuji Taketani, Haruko Hiraike, Genta Nagae, Kumi Shoji, Tomomi Nei, Yuriko Uehara, Osamu Hiraike-Wada, Yuichiro Miyamoto, Hiroyuki Aburatani
Publikováno v:
British Journal of Cancer
Background: The phosphatidylinositol 3′-kinase (PI3K)–AKT pathway is activated in many human cancers and plays a key role in cell proliferation and survival. A mutation (E17K) in the pleckstrin homology domain of the AKT1 results in constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db74df6e52e2d6abc2f304cd9ea39bb2
http://europepmc.org/articles/PMC2713716
http://europepmc.org/articles/PMC2713716