Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Kumi Shirai"'
Autor:
Yuka Okada, Kumi Shirai, Masayasu Miyajima, Peter S Reinach, Osamu Yamanaka, Takayoshi Sumioka, Masahide Kokado, Katsuo Tomoyose, Shizuya Saika
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167200 (2016)
In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also att
Externí odkaz:
https://doaj.org/article/189de724901d4a389ea277ef88928cd3
Autor:
Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika
Publikováno v:
Journal of Ophthalmology, Vol 2015 (2015)
To investigate the effects of loss of transient receptor potential vanilloid receptor 1 (TRPV1) on the development of neovascularization in corneal stroma in mice. Blocking TRPV1 receptor did not affect VEGF-dependent neovascularization in cell cultu
Externí odkaz:
https://doaj.org/article/2d8b0992c35743cf9e509aabb8f2ce1e
Publikováno v:
Case Reports in Ophthalmological Medicine, Vol 2011 (2011)
We report a case of corneal staphyloma histologically diagnosed as caused by Peters' anomaly. A 62-year-old male had a protruding opaque vascularized cornea that began to bulge from six months ago in the right eye. Since his right eye was blind and h
Externí odkaz:
https://doaj.org/article/ef7d47c04c5c48aba3338467bf7ddced
Autor:
Chia-Yang Liu, Atsushi Nambu, Yoshiro Suzuki, Winston Whei-Yang Kao, Masayasu Miyajima, Kenta Kobayashi, Makoto Tominaga, Takayoshi Sumioka, Kunitoshi Uchida, Hiromi Sano, Shizuya Saika, James V. Jester, Peter S. Reinach, Yuka Okada, Hiroki Iwanishi, Kumi Shirai, Syu-ichi Hirai, Kana Ichikawa
Publikováno v:
Laboratory Investigation. 99:210-230
In order to understand the pathobiology of neurotrophic keratopathy, we established a mouse model by coagulating the first branch of the trigeminal nerve (V1 nerve). In our model, the sensory nerve in the central cornea disappeared and remaining fibe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5c1b9a7d2c45d2fb33769c8150d921
https://doi.org/10.1038/s41374-018-0118-4
https://doi.org/10.1038/s41374-018-0118-4
Publikováno v:
Developmental Dynamics. 247:340-345
Epithelial-mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262298c79bce222f1c73ec887ea9310d
https://doi.org/10.1002/dvdy.24518
https://doi.org/10.1002/dvdy.24518
Autor:
Takayoshi Sumioka, Ai Kitano-Izutani, Masayasu Miyajima, Osamu Yamanaka, Yuka Okada, Kumi Shirai, Shizuya Saika, Peter S. Reinach
Publikováno v:
Cornea. 34:S136-S141
Corneal transparency is dependent on the maintenance of the structural integrity and functional activity of its epithelial and endothelial limiting layers and the stroma. Different transient receptor potential (TRP) channel subtypes are expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a18fff8dad49d4705f0a9106632dd
https://doi.org/10.1097/ico.0000000000000602
https://doi.org/10.1097/ico.0000000000000602
Publikováno v:
Developmental Dynamics
Epithelial–mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f4dea33eccebd17da0cf960decb94f8
https://pubmed.ncbi.nlm.nih.gov/28480986
https://pubmed.ncbi.nlm.nih.gov/28480986
Autor:
Yuka Okada, Ai Kitano, Takayoshi Sumioka, Shizuya Saika, Kumi Shirai, Hideaki Kokado, Osamu Yamanaka, Takeshi Miyamoto
Publikováno v:
The Ocular Surface. 11:12-15
The extracellular matrix components osteopontin and tenascin-C are ligands of α9 integrin, and both play roles in corneal wound fibrosis and neovascularization. It has been shown that loss of osteopontin impairs closure of incisional wounds in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed86eb009126fc58f53152f5aa02386e
https://doi.org/10.1016/j.jtos.2012.09.002
https://doi.org/10.1016/j.jtos.2012.09.002
Autor:
Masahide Kokado, Osamu Yamanaka, Kumi Shirai, Yuka Okada, Shizuya Saika, Takayoshi Sumioka, Masayasu Miyajima, Katsuo Tomoyose, Peter S. Reinach
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167200 (2016)
PLoS ONE
PLoS ONE
In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cdf7432310f6d9ff0ba79f2e72202f
http://europepmc.org/articles/PMC5193391?pdf=render
http://europepmc.org/articles/PMC5193391?pdf=render
Autor:
Winston W.-Y. Kao, Kumi Shirai, Yuka Okada, Peter S. Reinach, Kathleen C. Flanders, Masayasu Miyajima, Hongshan Liu, Ai Kitano, Jianhua Zhang, Shizuya Saika
Publikováno v:
The American Journal of Pathology. 178:2654-2664
We examined whether absence or blocking of transient receptor potential vanilloid subtype 1 (TRPV1) affects the level of inflammation and fibrosis/scarring during healing of injured tissue using an alkali burn model of cornea in mice. A cornea burn w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc009f8711fff54c6a52fe00eaadc0bb
https://doi.org/10.1016/j.ajpath.2011.02.043
https://doi.org/10.1016/j.ajpath.2011.02.043