Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Kumi Shirai"'
Autor:
Yuka Okada, Kumi Shirai, Masayasu Miyajima, Peter S Reinach, Osamu Yamanaka, Takayoshi Sumioka, Masahide Kokado, Katsuo Tomoyose, Shizuya Saika
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167200 (2016)
In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also att
Externí odkaz:
https://doaj.org/article/189de724901d4a389ea277ef88928cd3
Autor:
Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika
Publikováno v:
Journal of Ophthalmology, Vol 2015 (2015)
To investigate the effects of loss of transient receptor potential vanilloid receptor 1 (TRPV1) on the development of neovascularization in corneal stroma in mice. Blocking TRPV1 receptor did not affect VEGF-dependent neovascularization in cell cultu
Externí odkaz:
https://doaj.org/article/2d8b0992c35743cf9e509aabb8f2ce1e
Publikováno v:
Case Reports in Ophthalmological Medicine, Vol 2011 (2011)
We report a case of corneal staphyloma histologically diagnosed as caused by Peters' anomaly. A 62-year-old male had a protruding opaque vascularized cornea that began to bulge from six months ago in the right eye. Since his right eye was blind and h
Externí odkaz:
https://doaj.org/article/ef7d47c04c5c48aba3338467bf7ddced
Autor:
Chia-Yang Liu, Atsushi Nambu, Yoshiro Suzuki, Winston Whei-Yang Kao, Masayasu Miyajima, Kenta Kobayashi, Makoto Tominaga, Takayoshi Sumioka, Kunitoshi Uchida, Hiromi Sano, Shizuya Saika, James V. Jester, Peter S. Reinach, Yuka Okada, Hiroki Iwanishi, Kumi Shirai, Syu-ichi Hirai, Kana Ichikawa
Publikováno v:
Laboratory Investigation. 99:210-230
In order to understand the pathobiology of neurotrophic keratopathy, we established a mouse model by coagulating the first branch of the trigeminal nerve (V1 nerve). In our model, the sensory nerve in the central cornea disappeared and remaining fibe
Publikováno v:
Developmental Dynamics. 247:340-345
Epithelial-mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tissu
Autor:
Takayoshi Sumioka, Ai Kitano-Izutani, Masayasu Miyajima, Osamu Yamanaka, Yuka Okada, Kumi Shirai, Shizuya Saika, Peter S. Reinach
Publikováno v:
Cornea. 34:S136-S141
Corneal transparency is dependent on the maintenance of the structural integrity and functional activity of its epithelial and endothelial limiting layers and the stroma. Different transient receptor potential (TRP) channel subtypes are expressed in
Publikováno v:
Developmental Dynamics
Epithelial–mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tis
Autor:
Yuka Okada, Ai Kitano, Takayoshi Sumioka, Shizuya Saika, Kumi Shirai, Hideaki Kokado, Osamu Yamanaka, Takeshi Miyamoto
Publikováno v:
The Ocular Surface. 11:12-15
The extracellular matrix components osteopontin and tenascin-C are ligands of α9 integrin, and both play roles in corneal wound fibrosis and neovascularization. It has been shown that loss of osteopontin impairs closure of incisional wounds in the m
Autor:
Masahide Kokado, Osamu Yamanaka, Kumi Shirai, Yuka Okada, Shizuya Saika, Takayoshi Sumioka, Masayasu Miyajima, Katsuo Tomoyose, Peter S. Reinach
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167200 (2016)
PLoS ONE
PLoS ONE
In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also att
Autor:
Kumi Shirai, Shizuya Saika
Publikováno v:
BMC Ophthalmology
Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e. dr