Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kumi Morikawa"'
Autor:
Takayuki Wakimizu, Kumi Morikawa, Kenta Fukumura, Tetsuo Yuki, Takashi Adachi, Yasutaka Kurata, Junichiro Miake, Ichiro Hisatome, Motokazu Tsuneto, Yasuaki Shirayoshi
Publikováno v:
Regenerative Therapy, Vol 21, Iss , Pp 239-249 (2022)
Introduction: Dysfunction of the sinoatrial node (SAN) cells causes arrhythmias, and many patients require artificial cardiac pacemaker implantation. However, the mechanism of impaired SAN automaticity remains unknown, and the generation of human SAN
Externí odkaz:
https://doaj.org/article/3fa7457577374453870a7ddfa7f4b60b
Autor:
Kumi Morikawa, Kazuhiro Furuhashi, Carmen de Sena-Tomas, Alvaro L. Garcia-Garcia, Ramsey Bekdash, Alison D. Klein, Nicholas Gallerani, Hannah E. Yamamoto, Seon-Hye E. Park, Grant S. Collins, Fuun Kawano, Moritoshi Sato, Chyuan-Sheng Lin, Kimara L. Targoff, Edmund Au, Michael C. Salling, Masayuki Yazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Previous versions of photoactivatable Cre recombinase (PA-Cre) suffered from unintentional recombination in dark conditions. Here, the authors develop an improved version of PA-Cre, called PA-Cre 3.0, which shows reduced leakiness and improved effici
Externí odkaz:
https://doaj.org/article/4dd05e1b2991499aa94c1548679f42b6
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 50-57 (2017)
L-type calcium channel CaV1.2 plays an essential role in cardiac function. The gain-of-function mutations in CaV1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we de
Externí odkaz:
https://doaj.org/article/e83c48c9291d40b38fd509cbf4f957e1
Autor:
Takeshi Onohara, MD, Ichiro Hisatome, MD, Yasutaka Kurata, MD, Peili Li, MD, Tomomi Notsu, PhD, Kumi Morikawa, PhD, Naoyuki Otani, MD, Akio Yoshida, MD, Kazuhiko Iitsuka, MD, Masaru Kato, MD, Junichiro Miake, MD, Haruaki Ninomiya, MD, Katsumi Higaki, PhD, Yasuaki Shirayoshi, PhD, Takashi Nishihara, BE, Toshiyuki Itoh, PhD, Yoshinobu Nakamura, MD, Motonobu Nishimura, MD
Publikováno v:
Journal of Arrhythmia, Vol 33, Iss 3, Pp 226-233 (2017)
Background: Pilsicainide, classified as a relatively selective Na+ channel blocker, also has an inhibitory action on the rapidly-activating delayed-rectifier K+ current (IKr) through human ether-a-go-go-related gene (hERG) channels. We studied the ef
Externí odkaz:
https://doaj.org/article/79c1cda0789f496394eafca2f1b97d00
Autor:
Kumi Morikawa, Kazuomi Nakamura, Yoshiko Suyama, Kenshiro Yamamoto, Kohei Fukuoka, Shunjiro Yagi, Yasuaki Shirayoshi, Tetsuya Ohbayashi, Ichiro Hisatome
Publikováno v:
Biochemistry and Biophysics Reports, Vol 18, Iss , Pp - (2019)
In the present study, we have established a novel transgenic mouse and transgenic rats with dual reporters of EGFP and ELuc. In these transgenic (Tg) rodents, both GFP fluorescent and luciferase luminescent signals were ubiquitously detected in the h
Externí odkaz:
https://doaj.org/article/8962e8e7fe674a9bb106a4fd4356505a
Autor:
LouJin Song, Ramsey Bekdash, Kumi Morikawa, Jose R. Quejada, Alison D. Klein, Danielle Aina-Badejo, Kazushige Yoshida, Hannah E. Yamamoto, Amy Chalan, Risako Yang, Achchhe Patel, Dario Sirabella, Teresa M. Lee, Leroy C. Joseph, Fuun Kawano, Junco S. Warren, Rajesh K. Soni, John P. Morrow, Masayuki Yazawa
Publikováno v:
Nature Cardiovascular Research. 1:142-156
Some missense gain-of-function mutations in CACNA1C gene, encoding calcium channel CaV1.2, cause a life-threatening form of long QT syndrome named Timothy syndrome, with currently no clinically-effective therapeutics. Here we report that pharmacologi
Publikováno v:
Journal of Radiation Research
Ionizing radiation exposure affects the redox state in vivo. Recently, whole-blood antioxidant capacity (WBAC) has been reported to decrease in a dose-dependent manner after acute total body irradiation (TBI). However, changes in WBAC after localized
Publikováno v:
Journal of Radiation Research
The mammalian target of rapamycin (mTOR) is a sensor of nutrient status and plays an important role in cell growth and metabolism. Although inhibition of mTOR signaling promotes tumor cell death and several mTOR inhibitors have been used clinically,
Autor:
Shin Ito, Tomomi Notsu, Junichiro Miake, Yasuaki Shirayoshi, Masanari Kuwabara, Haruaki Ninomiya, Takayuki Wakimizu, Kumi Morikawa, Kazuhiro Yamamoto, Kenshiro Yamamoto, Mai Watanabe, Motonobu Nishimura, Takuki Sakaguchi, Maya Adachi, Takayuki Morisaki, Motokazu Tsuneto, Masafumi Kitakaze, Yasutaka Kurata, Yumiko Inoue, Hiromu Horie, Ichiro Hisatome
Publikováno v:
Circulation Journal. 85:657-666
Background Although adipose-derived stem cell (ADSC) sheets improve the cardiac function after myocardial infarction (MI), underlying mechanisms remain to be elucidated. The aim of this study was to determine the fate of transplanted ADSC sheets and
Autor:
Fuun Kawano, Tetz C. Lee, Shunnosuke Ueno, Alexander I. Sobolevsky, Chyuan-Sheng Lin, Koki Nakanishi, Kumi Morikawa, Ramsey Bekdash, Jose R. Quejada, Shunichi Homma, Keisuke Goda, Teresa M. Lee, Maria V. Yelshanskaya, Amy Chalan, Kenji Matsumoto, Masayuki Yazawa, Alison D. Klein, Rui Liu
Publikováno v:
Cell reports methods. 1(7)
Summary Lactate metabolism has been shown to have increasingly important implications in cellular functions as well as in the development and pathophysiology of disease. The various roles as a signaling molecule and metabolite have led to interest in