Výsledky vyhledávání - "Kumi Matsuno"

Pharmacokinetics and Safety After a Single Dose of Imarikiren in Subjects with Renal or Hepatic Impairment

Autor: Tomoya Kagawa, Tokurou Kobayashi, Shingo Kuroda, Masashi Sakaki, Yuhei Sano, Takuya Saiki, Emiko Koumura, Yukio Shimasaki, Kohei Shimizu, Minoru Itou, Kumi Matsuno, Masako Aso

Publikováno v: Clinical Drug Investigation. 38:1041-1051

Imarikiren hydrochloride (TAK-272; SCO-272) is a novel direct renin inhibitor. The objective of this study was to determine the effects of renal impairment (RI) or hepatic impairment (HI) on the pharmacokinetics and safety of imarikiren. This phase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77f19a2428e8c570a727f805ba5f8b2
https://doi.org/10.1007/s40261-018-0695-4

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A Randomized, Single-Center, Double-Blind, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Imarikiren in Healthy Adult Nonelderly and Elderly Male Subjects

Autor: Kumi Matsuno, Takamasa Hashimoto, Shingo Tanaka, Tomoya Kagawa, Emiko Koumura, Hiroyuki Nakamichi

Publikováno v: Journal of Clinical Pharmacology

Imarikiren hydrochloride (TAK‐272/ SCO‐272) is a novel direct renin inhibitor. This randomized, double‐blind, phase I study evaluated the safety and pharmacokinetics/pharmacodynamics of multiple oral administrations of imarikiren in healthy non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3456d1f5418bff6627cd74602cb51e90
https://doi.org/10.1002/jcph.1142

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Pharmacokinetics, Safety, and Tolerability of Vortioxetine Following Single‐ and Multiple‐Dose Administration in Healthy Japanese Adults

Autor: Koki Nakamura, Yutaka Aritomi, Kumi Matsuno, Akira Nishimura

Publikováno v: Clinical Pharmacology in Drug Development

Three phase 1 randomized single‐center studies assessed the pharmacokinetics, safety, and tolerability of vortioxetine after single‐ and multiple‐dose administration in healthy Japanese adults. Study 1 assessed the pharmacokinetics of vortioxet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e27486798b123d9ddfe65bdebe1608
http://europepmc.org/articles/PMC5900865

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Effects of oral iron and calcium supplement on the pharmacokinetics and pharmacodynamics of molidustat: an oral HIF-PH inhibitor for the treatment of renal anaemia

Autor: Stefanie Kapsa, Dorina van der Mey, Kumi Matsuno, Silvia Lentini, Andreas Kaiser

Publikováno v: European journal of clinical pharmacology. 76(2)

Purpose The present studies assessed the drug–drug interaction of molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, with iron and calcium supplements, which are common medications in patients with anaemia due to chronic kidney di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42da85c4b582e35dd0ff8c4a2e2205b
https://pubmed.ncbi.nlm.nih.gov/31919558

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Pharmacokinetics, Pharmacodynamics and Safety of a Single Dose of Imarikiren, a Novel Renin Inhibitor, in Healthy Male Subjects

Autor: Emiko Koumura, Shingo Tanaka, Tomoya Kagawa, Shingo Kuroda, Hiroyuki Nakamichi, Kumi Matsuno

Publikováno v: Basicclinical pharmacologytoxicology. 123(5)

Imarikiren hydrochloride (TAK-272/SCO-272) is a novel direct renin inhibitor with potential indications for cardiovascular and renal diseases. This phase I study evaluated the pharmacokinetics, pharmacodynamics and safety of a single oral administrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc393f6684afc43ac6a992cb202a0f40
https://pubmed.ncbi.nlm.nih.gov/29845723

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Evaluation of the bioequivalence of a fixed-dose combination tablet of pioglitazone–metformin versus commercial tablets in healthy Japanese male volunteers

Autor: Takaki Hayakawa, Kumi Matsuno, Shinzo Hiroi, Koji Kawakami, Masashi Hirayama, Norihito Yoshioka

Publikováno v: Diabetes Management. 2:13-20

SUMMARY In chronic asymptomatic diseases such as Type 2 diabetes mellitus (T2DM) poor adherence to therapy is a common problem. Simplification of treatment regimens using fixed-dose combination formulations has the potential to improve patient compli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84d28c87aa665b29c55d27de9f8dcc43
https://doi.org/10.2217/dmt.12.31

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Bioequivalence evaluation of pioglitazone orally disintegrating tablet formulation

Autor: Kumi Matsuno, Shinzo Hiroi, Koji Kawakami, Norihito Yoshioka, Takaki Hayakawa, Masashi Hirayama

Publikováno v: Diabetes Management. 2:3-11

SUMMARY Three studies were performed in healthy Japanese men to compare the bioavailability of an orally disintegrating tablet formulation of pioglitazone (pioglitazone OD tablet) with pioglitazone commercial tablets, and to determine the extent of o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a448459aeae09e7ae800acf8c20b533
https://doi.org/10.2217/dmt.12.29

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Bioequivalence of a pioglitazone–glimepiride combination tablet versus coadministered single-dose pioglitazone and glimepiride in healthy Japanese subjects

Autor: Kenji Kuriyama, Shinzo Hiroi, Kumi Matsuno, Masashi Hirayama, Koji Kawakami

Publikováno v: Diabetes Management. 2:21-28

SUMMARY For patients with Type 2 diabetes mellitus (T2DM) who require combination antidiabetic drug therapy to achieve glycemic control, fixed-dose combinations have the potential to improve compliance. The objective of this study was to assess the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8516fa4004f385d1226a3822a9b4bea
https://doi.org/10.2217/dmt.12.32

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