Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kumi, Kimura"'
Autor:
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, Yasuhiko Yamamoto, Masao Honda, Shun-ichiro Asahara, Kim Ravnskjaer, Shin-ichi Horike, Shuichi Kaneko, Masato Kasuga, Hiroyasu Nakano, Kenichi Harada, Hiroshi Inoue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a reg
Externí odkaz:
https://doaj.org/article/6e96d9a1b7674a218452a1194f8c9e95
Autor:
Kumi Kimura, Yuka Inaba, Hitoshi Watanabe, Toshiya Matsukawa, Michihiro Matsumoto, Hiroshi Inoue
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 3, Pp 659-666 (2019)
Abstract Aims/Introduction Non‐alcoholic steatohepatitis (NASH), which occurs in association with insulin resistance and hepatic fat accumulation, is characterized by chronic liver injury and fibrosis. NASH onset and progression is closely related
Externí odkaz:
https://doaj.org/article/b96096c9bd3444dbacf8665450886b42
Autor:
Hitoshi Watanabe, Yuka Inaba, Kumi Kimura, Michihiro Matsumoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory
Externí odkaz:
https://doaj.org/article/e09d63003b4f4c6d834180b9cb38c390
Autor:
Kumi Kimura, Mamoru Tanida, Naoto Nagata, Yuka Inaba, Hitoshi Watanabe, Mayumi Nagashimada, Tsuguhito Ota, Shun-ichiro Asahara, Yoshiaki Kido, Michihiro Matsumoto, Koji Toshinai, Masamitsu Nakazato, Toshishige Shibamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2362-2374 (2016)
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of hepatic gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated hepatic response; however, the precise mechanism
Externí odkaz:
https://doaj.org/article/4ece7d92e4724e31a995e093378b94c3
Autor:
Kenjiro Hayashi, Koichi Sato, Seishi Ochi, Shuhei Kawano, Seiichi Munesue, Ai Harashima, Yu Oshima, Kumi Kimura, Takashi Kyoi, Yasuhiko Yamamoto
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5757
Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21051e1f5db9811a6fc2cc6ab7e561a3
Publikováno v:
Journal of Diabetes Investigation
Aims/Introduction Sodium–glucose cotransporter 2 inhibitor (SGLT2i) lowers blood glucose and causes a whole‐body energy deficit by boosting renal glucose excretion, thus affecting glucose and energy metabolism. This energy deficit not only decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5eba9a7775e261bbd92e581577a960
https://doi.org/10.1111/jdi.13319
https://doi.org/10.1111/jdi.13319
Autor:
Yu Oshima, Ai Harashima, Seiichi Munesue, Kumi Kimura, Nontaphat Leerach, Hisanori Goto, Mariko Tanaka, Akane Niimura, Kenjiro Hayashi, Hiroshi Yamamoto, Haruhiro Higashida, Yasuhiko Yamamoto
Publikováno v:
International journal of molecular sciences. 23(4)
Non-enzymatic glycation is an unavoidable reaction that occurs across biological taxa. The final products of this irreversible reaction are called advanced glycation end-products (AGEs). The endogenously formed AGEs are known to be bioactive and detr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51fc8741532d05464e7d2fdbace15e0
https://pubmed.ncbi.nlm.nih.gov/35216202
https://pubmed.ncbi.nlm.nih.gov/35216202
Autor:
Kenjiro, Hayashi, Koichi, Sato, Seishi, Ochi, Shuhei, Kawano, Seiichi, Munesue, Ai, Harashima, Yu, Oshima, Kumi, Kimura, Takashi, Kyoi, Yasuhiko, Yamamoto
Publikováno v:
International journal of molecular sciences. 23(10)
Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4af394703e57309133d8dcec2bab6c6b
https://pubmed.ncbi.nlm.nih.gov/35628567
https://pubmed.ncbi.nlm.nih.gov/35628567
Autor:
Masaki Kobayashi, Hiroshi Inoue, Hitoshi Watanabe, Tadahiro Kitamura, Kumi Kimura, Emi Hashiuchi, Yuka Inaba, Masato Kasuga, Michihiro Matsumoto, Makoto Sato
Publikováno v:
Endocrinology. 160:2811-2824
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) consistently reduces blood glucose levels in type 2 diabetes mellitus but increases hepatic gluconeogenic gene expression and glucose production, offsetting its glucose-lowering effect. This study aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc15bcf49348d19dc75f9f69535bb99
https://doi.org/10.1210/en.2019-00422
https://doi.org/10.1210/en.2019-00422
Autor:
Toshiya Matsukawa, Hitoshi Watanabe, Michihiro Matsumoto, Hiroshi Inoue, Yuka Inaba, Kumi Kimura
Publikováno v:
Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 10, Iss 3, Pp 659-666 (2019)
Journal of Diabetes Investigation, Vol 10, Iss 3, Pp 659-666 (2019)
Aims/Introduction Non‐alcoholic steatohepatitis (NASH), which occurs in association with insulin resistance and hepatic fat accumulation, is characterized by chronic liver injury and fibrosis. NASH onset and progression is closely related to hepati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013543f44e3fc1550717fa11f492e41e
http://europepmc.org/articles/PMC6497582
http://europepmc.org/articles/PMC6497582