Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.

Autor: Gretarsson KH; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Abini-Agbomson S; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA., Gloor SL; EpiCypher Inc., Durham, NC 27709, USA., Weinberg DN; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., McCuiston JL; EpiCypher Inc., Durham, NC 27709, USA., Kumary VUS; EpiCypher Inc., Durham, NC 27709, USA., Hickman AR; EpiCypher Inc., Durham, NC 27709, USA., Sahu V; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Lee R; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA., Xu X; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Lipieta N; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Flashner S; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA., Adeleke OA; EpiCypher Inc., Durham, NC 27709, USA., Popova IK; EpiCypher Inc., Durham, NC 27709, USA., Taylor HF; EpiCypher Inc., Durham, NC 27709, USA., Noll K; EpiCypher Inc., Durham, NC 27709, USA., Windham CL; EpiCypher Inc., Durham, NC 27709, USA., Maryanski DN; EpiCypher Inc., Durham, NC 27709, USA., Venters BJ; EpiCypher Inc., Durham, NC 27709, USA., Nakagawa H; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA., Keogh MC; EpiCypher Inc., Durham, NC 27709, USA., Armache KJ; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA., Lu C; Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

Publikováno v: Science advances [Sci Adv] 2024 Aug 30; Vol. 10 (35), pp. eadp0975. Date of Electronic Publication: 2024 Aug 28.