Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kumari Sunita Prajapati"'
Publikováno v:
Metabolites, Vol 13, Iss 1, p 29 (2022)
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with minimal treatment options. In the present work, Withaferin A (WA), a natural steroidal lactone found in Withania somnifera (Solanaceae), was studied to deduce the miR
Externí odkaz:
https://doaj.org/article/9093d77e2359440dbf7e1f52da0bd803
Autor:
Shashank Kumar, Kumari Sunita Prajapati, Mohd Shuaib, Prem Prakash Kushwaha, Hardeep Singh Tuli, Atul Kumar Singh
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In the present article we present an update on the role of chemoprevention and other pharmacological activities reported on kurarinone, a natural flavanone (from 1970 to 2021). To the best of our knowledge this is the first and exhaustive review of k
Externí odkaz:
https://doaj.org/article/645026602b194023a3fb06ba68e6aa5e
Autor:
Prem Prakash Kushwaha, Atul Kumar Singh, Tanya Bansal, Akansha Yadav, Kumari Sunita Prajapati, Mohd Shuaib, Shashank Kumar
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The present study explores the SARS-CoV-2 drugable target inhibition efficacy of phytochemicals from Indian medicinal plants using molecular docking, molecular dynamics (MD) simulation, and MM-PBSA analysis. A total of 130 phytochemicals were screene
Externí odkaz:
https://doaj.org/article/01a21985e57444eb93d6e5b17f31742e
Publikováno v:
Metabolites, Vol 12, Iss 10, p 926 (2022)
Rutin, a natural flavonol, can modulate molecular signaling pathways and has considerable potential in cancer treatment. However, little is known about the effect of rutin on the notch signaling pathway (NSP) in cancer and cancer stem-like cells. In
Externí odkaz:
https://doaj.org/article/2e833129fe7f4c91a9f49232cdc30cb6
Publikováno v:
Current Pharmaceutical Design. 28:2890-2900
Background: In bacteria, peptide deformylase (PDF), a metalloenzyme, removes N-formyl methionine from a nascent protein, which is a critical step in the protein maturation process. The enzyme is ubiquitously present in bacteria and possesses therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ec693fb11e508c8459afd4e643acbf
https://doi.org/10.2174/1381612828666220922100556
https://doi.org/10.2174/1381612828666220922100556
Publikováno v:
Colloid and Polymer Science. 300:1037-1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989a6607bef1703565d898f5a76ce188
https://doi.org/10.1007/s00396-022-05010-z
https://doi.org/10.1007/s00396-022-05010-z
Publikováno v:
Molecular Carcinogenesis. 61:876-889
Breast cancer is a heterogeneous disease consisting of atypical cell populations that share stem cell-like characteristics associated with therapeutic resistance, disease relapse, and poor clinical outcome. MicroRNAs (miRNA), and small noncoding RNA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c17e8c1f2cbfcff2c3fa852445c598
https://doi.org/10.1002/mc.23440
https://doi.org/10.1002/mc.23440
Discovery of differentially expressed novel miRNAs in breast normal cells and their putative targets
Publikováno v:
Molecular and Cellular Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0133e8e0fd69f1983a2ac66b2781f2c4
https://doi.org/10.1007/s11010-023-04665-8
https://doi.org/10.1007/s11010-023-04665-8
Publikováno v:
Journal of biomolecular structuredynamics.
Gamma secretase (GS) produces Notch Intracellular Domain (NICD) by trans-membrane cleavage of notch receptor. The NICD enters the nucleus and activates the notch signaling pathway (NSP) by activating notch-responsive gene transcription. Hyperactivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1151ff3ac09e652a98d488355ef1ec
https://pubmed.ncbi.nlm.nih.gov/36239003
https://pubmed.ncbi.nlm.nih.gov/36239003
Autor:
Prem Prakash Kushwaha, Shashank Kumar, Kumari Sunita Prajapati, Mohammad Waseem, Mohd Shuaib, Atul Kumar Singh
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:11676-11690
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype generally associated with younger women. Due to the lack of suitable drugable targets in TNBC, the microRNAs are considered as a better hope as therapeutic agents for the man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ccf6bb535690b1e96cc4b1dee57327
https://doi.org/10.1080/07391102.2021.1961869
https://doi.org/10.1080/07391102.2021.1961869