Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kumari G Lokugamage"'
Autor:
Bryan A Johnson, Yiyang Zhou, Kumari G Lokugamage, Michelle N Vu, Nathen Bopp, Patricia A Crocquet-Valdes, Birte Kalveram, Craig Schindewolf, Yang Liu, Dionna Scharton, Jessica A Plante, Xuping Xie, Patricia Aguilar, Scott C Weaver, Pei-Yong Shi, David H Walker, Andrew L Routh, Kenneth S Plante, Vineet D Menachery
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010627 (2022)
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203-205 in the SARS-CoV-2 nucleocapsid prot
Externí odkaz:
https://doaj.org/article/0031142558fa4dd18fd3b0b776dc19ca
Autor:
Cheng Huang, Kumari G Lokugamage, Janet M Rozovics, Krishna Narayanan, Bert L Semler, Shinji Makino
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002433 (2011)
SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous
Externí odkaz:
https://doaj.org/article/3428afd3543d4aa08847c4dee20db223
Autor:
Zemin Yang, Bryan A. Johnson, Victoria A. Meliopoulos, Xiaohui Ju, Peipei Zhang, Michael P. Hughes, Jinjun Wu, Kaitlin P. Koreski, Jemma E. Clary, Ti-Cheng Chang, Gang Wu, Jeff Hixon, Jay Duffner, Kathy Wong, Rene Lemieux, Kumari G. Lokugamage, R. Elias Alvarado, Patricia A. Crocquet-Valdes, David H. Walker, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Hong Joo Kim, Rachel Meyers, Stacey Schultz-Cherry, Qiang Ding, Vineet D. Menachery, J. Paul Taylor
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113965- (2024)
Summary: G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress g
Externí odkaz:
https://doaj.org/article/34285ee87dee48f994909c7562854676
Autor:
Xuping Xie, Antonio E. Muruato, Xianwen Zhang, Kumari G. Lokugamage, Camila R. Fontes-Garfias, Jing Zou, Jianying Liu, Ping Ren, Mini Balakrishnan, Tomas Cihlar, Chien-Te K. Tseng, Shinji Makino, Vineet D. Menachery, John P. Bilello, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/5bcace2bce144897896504eaa9828c77
Autor:
Michelle N. Vu, Dorothea R. Morris, R. Elias Alvarado, Kumari G. Lokugamage, Yiyang Zhou, Leah K. Estes, Alyssa M. McLeland, Craig Schindewolf, Jessica A. Plante, Yani P. Ahearn, Angelica L. Morgan, William M. Meyers, Jordan T. Murray, Scott C. Weaver, David H. Walker, William K. Russell, Andrew L. Routh, Kenneth S. Plante, Vineet Menachery
Publikováno v:
bioRxiv
SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on the impact of receptor binding domain changes, mutations in the C-terminal of S1 (CTS1), adjacent to the furin cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf8007697b39d3c4252dfed1a310974
https://doi.org/10.1101/2023.04.17.536926
https://doi.org/10.1101/2023.04.17.536926
Autor:
Michelle N. Vu, Kumari G. Lokugamage, Jessica A. Plante, Dionna Scharton, Aaron O. Bailey, Stephanea Sotcheff, Daniele M. Swetnam, Bryan A. Johnson, Craig Schindewolf, R. Elias Alvarado, Patricia A. Crocquet-Valdes, Kari Debbink, Scott C. Weaver, David H. Walker, William K. Russell, Andrew L. Routh, Kenneth S. Plante, Vineet D. Menachery
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike processing. Similarly, the QTQTN motif directly upstream of the FCS
Autor:
Zhiqiang Ku, Scott C. Weaver, Xianwen Zhang, Hongjie Xia, Jessica A. Plante, Jing Zou, Yang Liu, Zhiqiang An, John P. Bilello, Kenneth S. Plante, Dionna Scharton, Alexander N. Freiberg, Antonio E. Muruato, Xuping Xie, Camila R. Fontes-Garfias, Pei Yong Shi, Divya Mirchandani, Jianying Liu, Birte Kalveram, Bryan A. Johnson, Vineet D. Menachery, Kumari G. Lokugamage
Publikováno v:
Nature
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic1,2. However, the effect of this variant on viral spread and vaccine efficacy rem
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States
Autor:
Shifaq Kamili, Kenneth S. Plante, Yan Li, Rashi Gautam, Craig Schindewolf, Lijuan Wang, Krishna Narayanan, Hannah A. Bullock, Janna Murray, Brett Whitaker, Brian Lynch, Natalie J. Thornburg, Azaibi Tamin, Cynthia S. Goldsmith, Scott C. Weaver, Shinji Makino, Clinton R. Paden, Stephen Lindstrom, Dionna Scharton, Ying Tao, Kumari G. Lokugamage, Anna Uehara, Jing Zhang, Krista Queen, Senthil Kumar K. Sakthivel, Steven G. Widen, Vineet D. Menachery, Haibin Wang, Xiaoyan Lu, Suxiang Tong, Thomas G. Ksiazek, Divya Mirchandani, Jennifer L Harcourt, Jessica A. Plante
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 6, Pp 1266-1273 (2020)
Emerging Infectious Diseases
Emerging Infectious Diseases
The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 in January 2020. A patient in the United States was given a diagnosis of infection with this virus by the state of Wash
Autor:
Michelle N. Vu, Kumari G. Lokugamage, Jessica A. Plante, Dionna Scharton, Bryan A. Johnson, Stephanea Sotcheff, Daniele M. Swetnam, Craig Schindewolf, R. Elias Alvarado, Patricia A. Crocquet-Valdes, Kari Debbink, Scott C. Weaver, David H. Walker, Andrew L. Routh, Kenneth S. Plante, Vineet D. Menachery
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike processing 1,2. Similarly, the QTQTN motif directly upstream of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3038ad81caad7d46a913a88cef71f6
https://doi.org/10.1101/2021.12.15.472450
https://doi.org/10.1101/2021.12.15.472450
Autor:
Bryan A. Johnson, Yiyang Zhou, Kumari G. Lokugamage, Michelle N. Vu, Nathen Bopp, Patricia A. Crocquet-Valdes, Birte Kalveram, Craig Schindewolf, Yang Liu, Dionna Scharton, Jessica A. Plante, Xuping Xie, Patricia Aguilar, Scott C. Weaver, Pei-Yong Shi, David H. Walker, Andrew L. Routh, Kenneth S. Plante, Vineet D. Menachery
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203–205 in SARS-CoV-2 nucleocapsid protei