Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kumaravel Selvakumar"'
Autor:
Anne Rose, Qihong Zhao, Kumaravel Selvakumar, Percy H. Carter, Prakash Anjanappa, Jing Chen, Sandhya Mandlekar, Mary Ellen Cvijic, Andrew J. Tebben, Songmei Xu, Gregory D. Brown, Venkatram Reddy Paidi, Arvind Mathur, Douglas G. Batt, Jian Pang, Joel C. Barrish, Robert J. Cherney, Melissa Yarde, Ragini Vuppugalla
Publikováno v:
ACS Med Chem Lett
[Image: see text] BMS-813160 (compound 3) was identified as a potent and selective CCR2/5 dual antagonist. Compound 3 displayed good permeability at pH = 7.4 in PAMPA experiments and demonstrated excellent human liver microsome stability. Pharmacokin
Akademický článek
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Autor:
Carolyn A. Weigelt, Sha Li, David Marcoux, Georgia Cornelius, Qihong Zhao, Mary Ellen Cvijic, John E. Macor, Jingwu Duan, Melissa Yarde, Muthalagu Vetrichelvan, David J. Shuster, Qingjie Liu, Richard Rampulla, Kim W. McIntyre, Mary T. Obermeier, Shiuhang Yip, Purnima Khandelwal, Sureshbabu Vishwakrishnan, Anuradha Gupta, Virna Borowski, Peng Li, Kevin Stefanski, Sridharan Ramlingam, Myra Beaudoin-Bertrand, Nageswara Maddala, Sridhar Vanteru, Percy H. Carter, Arvind Mathur, Aberra Fura, Max Ruzanov, John Hynes, Dauh-Rurng Wu, Jinhong Wang, Luisa Salter-Cid, John S. Sack, Cornelius Lyndon A M, Anurag S. Srivastava, Robert J. Cherney, Kumaravel Selvakumar, Mushkin Basha, Arun Kumar Gupta, Douglas G. Batt, Rex Denton, Sukhen Karmakar, Qing Shi, Ananta Karmakar, Naveen Manjunath, Javed Khan, Jenny Xie, Joseph A. Tino, T. G. Murali Dhar
Publikováno v:
Journal of Medicinal Chemistry. 62:9931-9946
RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a potential target for the treatment of various immunological disorders su
Autor:
Lu, Zhonghui, Duan, James J.-W., Xiao, Haiyun, Neels, James, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, An, Yongmi, Yarde, Melissa, Karmakar, Ananta, Vishwakrishnan, Sureshbabu, Baratam, Venkata, Shankarappa, Harisha, Vanteru, Sridhar, Babu, Venkatesh, Basha, Mushkin, Kumar Gupta, Arun, Kumaravel, Selvakumar, Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2265-2269
Autor:
Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar
Publikováno v:
Journal of Medicinal Chemistry. 60:4369-4385
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B palm site al
Autor:
Cheng, Peter T. W., Kaltenbach III, Robert F., Hao Zhang, Jun Shi, Shiwei Tao, Jun Li, Kennedy, Lawrence J., Walker, Steven J., Yan Shi, Ying Wang, Dhanusu, Suresh, Reddigunta, Ramesh, Kumaravel, Selvakumar, Jusuf, Sutjano, Smith, Daniel, Krishnananthan, Subramaniam, Jianqing Li, Tao Wang, Heiry, Rebekah, Chi Shing Sum
Publikováno v:
Journal of Medicinal Chemistry; 11/11/2021, Vol. 64 Issue 21, p15549-15581, 33p
Autor:
Hua Fang, Kevin Kish, Mark R. Witmer, Matthew G. Soars, Kyle Parcella, Brett R. Beno, Ying-Kai Wang, Prakash Anjanappa, Julie A. Lemm, Karen Rigat, Katherine A. Grant-Young, Kap-Sun Yeung, Kathy Mosure, Steven Sheriff, Kenneth S. Santone, Jeffrey Tredup, Dawn D. Parker, John F. Kadow, Rajesh Onkardas Bora, Mengping Liu, Nicholas A. Meanwell, Susan B. Roberts, Adam G. Jardel, Rudolph G. Krause, Juliang Zhu, Kumaravel Selvakumar, Roy Haskell
[Image: see text] In solving the P-gp and BCRP transporter-mediated efflux issue in a series of benzofuran-derived pan-genotypic palm site inhibitors of the hepatitis C virus NS5B replicase, it was found that close attention to physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b87c17f58394ad90d7b8ea7bef1817f
https://europepmc.org/articles/PMC6295864/
https://europepmc.org/articles/PMC6295864/
Autor:
Siva Prasad Putlur, Kumaravel Selvakumar, Deepak Ahire, Ramesh Kumar Sistla, Santosh Wagh, Sarmistha Sinha, Benjamin M. Johnson, Janet Caceres Cortes, Sandhya Mandlekar, Dibakar Mullick
Publikováno v:
Chemical Research in Toxicology. 27:2052-2061
Certain aromatic nitriles are well-known inhibitors of cysteine proteases. The mode of action of these compounds involves the formation of a reversible or irreversible covalent bond between the nitrile and a thiol group in the active site of the enzy
Autor:
Anjanappa Prakash, Kumaravel Selvakumar, Manickam Sivakumar, Kandasamy Ruckmani, Mullick Dibakar
Publikováno v:
Tetrahedron Letters. 52:5338-5341
2-(Trimethylsilyl)ethanol as a new alcohol equivalent has been employed for copper-catalyzed coupling of aryl iodides. Using mild reaction conditions, it has been observed that substituted phenols and phenols with sensitive functional groups can be r
Autor:
Dibakar Mullick, Kandasamy Ruckmani, Manickam Sivakumar, Prakash Anjanappa, Kumaravel Selvakumar
Publikováno v:
Tetrahedron Letters. 51:5984-5987
Carbamic acid 2-trimethylsilylethyl ester (Teoc-NH 2 ) serves as an ammonia equivalent in the palladium-catalyzed amination of aryl bromides and aryl chlorides. Anilines with sensitive functional groups can be readily prepared using these amine deriv