Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Autor: Daokun Sun, Melissa A. Richard, Solomon K. Musani, Yun Ju Sung, Thomas W. Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O. Kilpeläinen, Dina Vojinovic, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Michael R. Brown, Kumaraswamy Chitrala, Fernando P. Hartwig, Andrea R.V.R. Horimoto, Yongmei Liu, Alisa K. Manning, Raymond Noordam, Albert V. Smith, Sarah E. Harris, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Ilja M. Nolte, Rainer Rauramaa, Peter J. van der Most, Rujia Wang, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Dan E. Arking, Donna K. Arnett, Ana Barac, Eric Boerwinkle, Ulrich Broeckel, Aravinda Chakravarti, Yii-Der Ida Chen, L. Adrienne Cupples, Martha L. Davigulus, Lisa de las Fuentes, Renée de Mutsert, Paul S. de Vries, Joseph A.C. Delaney, Ana V. Diez Roux, Marcus Dörr, Jessica D. Faul, Amanda M. Fretts, Linda C. Gallo, Hans Jörgen Grabe, C. Charles Gu, Tamara B. Harris, Catharina C.A. Hartman, Sami Heikkinen, M. Arfan Ikram, Carmen Isasi, W. Craig Johnson, Jost Bruno Jonas, Robert C. Kaplan, Pirjo Komulainen, Jose E. Krieger, Daniel Levy, Jianjun Liu, Kurt Lohman, Annemarie I. Luik, Lisa W. Martin, Thomas Meitinger, Yuri Milaneschi, Jeff R. O’Connell, Walter R. Palmas, Annette Peters, Patricia A. Peyser, Laura Pulkki-Råback, Leslie J. Raffel, Alex P. Reiner, Kenneth Rice, Jennifer G. Robinson, Frits R. Rosendaal, Carsten Oliver Schmidt, Pamela J. Schreiner, Lars Schwettmann, James M. Shikany, Xiao-ou Shu, Stephen Sidney, Mario Sims, Jennifer A. Smith, Nona Sotoodehnia, Konstantin Strauch, E. Shyong Tai, Kent D. Taylor, André G. Uitterlinden, Cornelia M. van Duijn, Melanie Waldenberger, Hwee-Lin Wee, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Donglin Zeng, Wei Zhao, Xiaofeng Zhu, Alan B. Zonderman, Diane M. Becker, Ian J. Deary, Christian Gieger, Timo A. Lakka, Terho Lehtimäki, Kari E. North, Albertine J. Oldehinkel, Brenda W.J.H. Penninx, Harold Snieder, Ya-Xing Wang, David R. Weir, Wei Zheng, Michele K. Evans, W. James Gauderman, Vilmundur Gudnason, Bernardo L. Horta, Ching-Ti Liu, Dennis O. Mook-Kanamori, Alanna C. Morrison, Alexandre C. Pereira, Bruce M. Psaty, Najaf Amin, Ervin R. Fox, Charles Kooperberg, Xueling Sim, Laura Bierut, Jerome I. Rotter, Sharon L.R. Kardia, Nora Franceschini, Dabeeru C. Rao, Myriam Fornage

Publikováno v: HGG Advances, Vol 2, Iss 1, Pp 100013- (2021)

Summary: Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastol

Externí odkaz: https://doaj.org/article/2b574045f7c748e0b85031d0e9674021

Integrative metatranscriptomic analysis reveals disease-specific microbiome-host interactions in oral squamous cell carcinoma

Autor: Vinay Jain, Divyashari Baraniya, Tsute Chen, Michael Slifker, Fadhl Alakwaa, Kathy Cai, Kumaraswamy Chitrala, Christopher Fundakowski, Nezar Al-hebshi

Studies on the microbiome of oral squamous cell carcinoma (OSCC) have been largely limited to 16S rRNA gene sequencing. Here, we used laser microdissection coupled with metatranscriptome sequencing at unprecedented depth (~ 400 million sequences/samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afdee1d12ab0996e1e35eeba6e59a363
https://doi.org/10.21203/rs.3.rs-1689707/v1

Additional file 3: of Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

Autor: Tajuddin, Salman, Hernandez, Dena, Chen, Brian, Hooten, Nicole Noren, Mode, Nicolle, Nalls, Mike, Singleton, Andrew, Ngozi Ejiogu, Kumaraswamy Chitrala, Zonderman, Alan, Evans, Michele

Figure S2. Scatter plots and Pearsonâ s correlation coefficients of methylation M values of top ten age-associated differentially methylated CpG positions (aDMPs) and chronological age in (a) African Americans and (b) whites. (PPTX 121 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34051204208efe80a19896409c18b4b1