Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kumaralal Kaluarachchi"'
Autor:
Madhuri Sankaranarayanapillai, William P. Tong, Qing Yuan, James A. Bankson, Hagit Dafni, William G. Bornmann, Suren Soghomonyan, Ashutosh Pal, Marc S. Ramirez, Douglas Webb, Kumaralal Kaluarachchi, Juri G. Gelovani, Sabrina M. Ronen
Publikováno v:
Molecular Imaging, Vol 7 (2008)
Histone deacetylase inhibitors (HDACis) are emerging as promising and selective antitumor agents. However, HDACis can lead to tumor stasis rather than shrinkage, in which case, traditional imaging methods are not adequate to monitor response. Consequ
Externí odkaz:
https://doaj.org/article/8abfa12acf104e9ea15b439bc8a78d02
Autor:
Warren S.-L. Liao, Xiaomin Chen, J. Sanderson Birtwistle, Fengqin Gao, Pijus K. Mandal, John S. McMurray, Zhen Lu, Rajagopal Ramesh, Kumaralal Kaluarachchi, Robert C. Bast, Zhiyong Ren
Publikováno v:
Journal of Medicinal Chemistry. 54:3549-3563
Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on growth factor and cytokine receptors via its SH2 domain. We report here structure-activity rel
Autor:
Madhuri Sankaranarayanapillai, Kumaralal Kaluarachchi, Amer Najjar, Sabrina M. Ronen, James T. Ross, William P. Tong
Publikováno v:
Molecular Cancer Therapeutics. 7:2556-2565
Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer. Consequently, FASN is a novel target for cancer therapy. However, because FASN inhibitors can lead to tu
Publikováno v:
International Journal of Peptide Research and Therapeutics. 14:1-9
To answer the question of whether the conformation of the Leu-Pro bond is cis or trans in Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 when complexed with the SH2 domain of Stat3, we substituted 2,2-dimethyloxazolidines derived from serine (Ser(ΨMe,Mepro)) and t
Autor:
Jianpeng Ma, Kumaralal Kaluarachchi, Mingzhi Chen, Seetharaman Balasenthil, Rajesh R. Singh, Suresh K. Rayala, Rakesh Kumar
Publikováno v:
Journal of Biological Chemistry. 281:25612-25621
Metastasis tumor-associated 1 short form (MTA1s) is a naturally occurring, alternatively spliced variant of MTA1 that functions as a repressor of estrogen receptor (ER) alpha transcriptional functions, at least in part by binding and sequestering ERa
Autor:
David G. Gorenstein, Varatharasa Thiviyanathan, Kumaralal Kaluarachchi, Yan Yang, Stanley M. Lemon, Rene Rijnbrand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(34)
Picornaviruses constitute a medically important family of RNA viruses in which genome replication critically depends on a small RNA element, the cis-acting replication element ( cre ), that templates 3D pol polymerase-catalyzed uridylylation of the p
Autor:
David G. Gorenstein, Varatharasa Thiviyanathan, Rene Rijnbrand, Kumaralal Kaluarachchi, Stanley M. Lemon
Publikováno v:
Journal of molecular biology. 343(4)
Translation of the open reading frames (ORF) of the hepatitis C virus (HCV) and closely related GB virus B (GBV-B) genomes is driven by internal ribosome entry site (IRES) elements located within the 5' non-translated RNA. The functioning of these IR
Publikováno v:
CIÊNCIAVITAE
Scopus-Elsevier
Scopus-Elsevier
Retroviral nucleocapsid proteins (NCPs) are CCHC-type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation. Mason-Pfizer monkey virus (MPMV), a type D retrovirus, encodes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c945db0835b3cfe2aba2cceeaf1cabff
https://europepmc.org/articles/PMC2143852/
https://europepmc.org/articles/PMC2143852/
Publikováno v:
Biochemistry. 30(36)
The accuracy and precision of structures derived from a combined hybrid relaxation rate matrix/NOESY distance restrained molecular dynamics methodology were examined with simulations that included typical experimental errors. NOESY data were simulate
Autor:
N. H. Wells, Rafael Martín, Kumaralal Kaluarachchi, R Sadagopan, M Heard, M Martin, Jose A. Bencomo
Publikováno v:
Medical Physics. 35:2796-2796
Purpose: To discuss the relation between cross‐linking and sensitivity enhancement in normoxic polymergels in a dose range suitable for intensity modulated radiotherapy, based on considerations related to actual sensor preparation methods and a the