Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kumara Dissanayake"'
Autor:
Liberty François-Moutal, David Donald Scott, Andrew J. Ambrose, Christopher J. Zerio, Marina Rodriguez-Sanchez, Kumara Dissanayake, Danielle G. May, Jacob M. Carlson, Edward Barbieri, Aubin Moutal, Kyle J. Roux, James Shorter, Rajesh Khanna, Sami J. Barmada, Leeanne McGurk, May Khanna
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It
Externí odkaz:
https://doaj.org/article/15ebfd3809d6429cb150916d1d91bb88
Autor:
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publikováno v:
eLife, Vol 5 (2016)
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2
Externí odkaz:
https://doaj.org/article/22e15996b1d34e3eb9da975e48348923
Publikováno v:
Open Biology, Vol 4, Iss 5 (2014)
The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD—termed 2R-ohnologues—belong to families
Externí odkaz:
https://doaj.org/article/41b27477dd6f43e1b22d372b8f9d02c3
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73327 (2013)
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood. IRS4 ove
Externí odkaz:
https://doaj.org/article/5d0df97bb66b467aa2d53a4789674f91
Autor:
Imasha Upulini Jayasinghe, Thilini Chanchala Agampodi, Ajith Kumara Dissanayake, Suneth Buddhika Agampodi
Publikováno v:
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Despite the intergenerational effects of metabolic disorders, evidence is greatly lacking on early pregnancy metabolic syndrome (MetS) and its effects on pregnancy outcomes from low- and middle-income countries. Thus, this prospec
Externí odkaz:
https://doaj.org/article/23b09068873a4100a11a46a0b3618a47
Autor:
Imasha Upulini, Jayasinghe, Thilini Chanchala, Agampodi, Ajith Kumara, Dissanayake, Shalka Madushan, Srimantha, Suneth Buddhika, Agampodi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Metabolic syndrome (MetS) in pregnancy shows epigenetic associations with intergenerational inheritance of metabolic diseases. The presence of different diagnostic criteria influences MetS prevalence estimates. We evaluated MetS and metabolic derange
Publikováno v:
Journal of Activity, Sedentary and Sleep Behaviors. 1
Background Maternal physical activity is beneficial to pregnant women, fetus and newborns. Evidence suggests that the level of physical activity in this group is not up to the expectation around the world. Lack of knowledge on the benefits of physica
Publikováno v:
Endocrine Abstracts.
Autor:
Liberty François-Moutal, David Scott, Andrew Ambrose, Christopher Zerio, Kumara Dissanayake, Danielle May, Jacob Carlson, Edward Barbieri, Aubin Moutal, Kyle Roux, James Shorter, Rajesh Khanna, Sami Barmada, Leeanne McGurk, May Khanna
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It is widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3bf18c2e6679edf27469aa4471eb77
https://doi.org/10.21203/rs.3.rs-1090289/v1
https://doi.org/10.21203/rs.3.rs-1090289/v1
Autor:
Liberty François-Moutal, David Donald Scott, Andrew J. Ambrose, Christopher J. Zerio, Marina Rodriguez-Sanchez, Kumara Dissanayake, Danielle G. May, Jacob M. Carlson, Edward Barbieri, Aubin Moutal, Kyle J. Roux, James Shorter, Rajesh Khanna, Sami J. Barmada, Leeanne McGurk, May Khanna
Publikováno v:
Scientific reports. 12(1)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It is widel