Výsledky vyhledávání - "Kumar V.S Nemmani"

Advancing health care via artificial intelligence: From concept to clinic

Autor: Grandhi Sandeep Ganesh, Aravinda Sai Kolusu, Konduri Prasad, Pavan Kumar Samudrala, Kumar V.S. Nemmani

Publikováno v: European journal of pharmacology. 934

Ever Since, pharmaceutical companies are facing challenges to develop new drug products faster and economical with good quality, safety and efficacy. The advent of Artificial intelligence (AI) with computational technology empowers scientists, impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acae2523cbd69f07cb4cbd01dc84cad6
https://pubmed.ncbi.nlm.nih.gov/36220360

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Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis

Publikováno v: European Journal of Pharmacology. 927:175054

PI3Kδ plays a critical role in adaptive immune cell activation and function. Suppression of PI3Kδ has been shown to counter excessive triggering of immune responses which has led to delineating the role of this isoform in the pathophysiology of aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa76af2abcce55ae46c64c0a261b565
https://doi.org/10.1016/j.ejphar.2022.175054

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EVALUATION OF CURCUMIN AGAINST CUPRIZONE INDUCED MOUSE MODEL OF MULTIPLE SCLEROSIS

Autor: Manikanta N.V. Anisetti*, N. Priyanka, Sk. Manish, Chandrasekhar Kommavari, Prasad Konduri, Kumar V.S. Nemmani

Multiple sclerosis (MS) is a chronic demyelinating disorder that affects the neurons in the central nervous system. The current drugs used for the treatment of MS are expensive and involves toxicity related issues, so there is a need to discover inex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c186afa99575bf90356a96fb254750

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Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes

Autor: Rashmi Talwar, Rajan Goel, Rekha R Shenoy, Umakant Ashok Bahirat, Kumar V.S. Nemmani

Publikováno v: Medical Molecular Morphology. 52:36-43

Non-alcoholic steatohepatitis (NASH) is characterized by the presence of hepatic steatosis, oxidative stress, inflammation, and hepatocyte injury with or without fibrosis. In this study, we explored the effect of APD668, a GPR119 agonist alone or in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423667d84bdfe04b78cc89927995d0ba
https://doi.org/10.1007/s00795-018-0200-4

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Bilateral quinolinic acid-induced lipid peroxidation, decreased striatal monoamine levels and neurobehavioral deficits are ameliorated by GIP receptor agonist D-Ala 2 GIP in rat model of Huntington's disease

Autor: Kumar V.S. Nemmani, Krishnadas Nandakumar, Rajan Goel, Mahip K. Verma

Publikováno v: European Journal of Pharmacology. 828:31-41

Huntington's disease (HD) is an inherited complex progressive neurodegenerative disorder with an established etiopathology linked to neuronal oxidative stress and corticostriatal excitotoxicity. Present study explores the effects of glucose-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e0e7f7d353d863d59c9f5523c10850
https://doi.org/10.1016/j.ejphar.2018.03.034

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Effect of D-Ala 2 GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice

Autor: Kumar V.S. Nemmani, Krishnadas Nandakumar, Rajan Goel, Mahip K. Verma

Publikováno v: European Journal of Pharmacology. 804:38-45

The aim of the present study was to evaluate the ability of D-Ala2GIP, a gastric inhibitory polypeptide (GIP) receptor agonist, to attenuate the behavioral phenotype of Parkinson's disease caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc99a70e7faf875be326f0c5385d4905
https://doi.org/10.1016/j.ejphar.2017.03.059

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APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

Autor: Rajan Goel, Umakant Ashok Bahirat, Kumar V.S. Nemmani, Rekha R Shenoy

Publikováno v: European Journal of Pharmacology. 801:35-45

G-protein coupled receptor 119 (GPR119) receptor is a rhodopsin-like, class A Gαs-coupled receptor, predominantly expressed in pancreatic islet cells and intestinal entero-endocrine cells. GPR119 has been emerged as a novel therapeutic target for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2ff65fac714f8391e59b46d5ed30b4
https://doi.org/10.1016/j.ejphar.2017.02.043

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Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice

Autor: Jayasagar Gundu, Kumar V.S. Nemmani, Prashant B. Nigade, K. Sreedhara Pai

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 42:835-847

Majority of reported studies so far developed correlation regression equations using the rat muscle-to-plasma drug concentration ratio (Kp-muscle) to predict tissue-to-plasma drug concentration ratios (Kp-tissues). Use of regression equations derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719a72ccf3e94398e3f2e2d40a1e22b
https://doi.org/10.1007/s13318-017-0402-5

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Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization

Autor: Albi Francis, Javed S. Shaikh, Tariq Bhat, Sanjay P. Kurhade, Nivrutti Kamble, Harish Volam, Sadanand Mallurwar, Pushpak Bora, Prashant B. Nigade, Mandar Bhonde, Hemant Goyal, Gagan Kukreja, Nishant R. Gupta, Nageswara Rao Irlapati, Prajakta Ahirrao, Bernstein Peter Robert, Rajesh B. Shankar, Kumar Ram Naik, Sneha Naidu, Gopal Gole, Yogesh Pawar, Apparao Bommakanti, Vinod Patil, Rajendra G. Powar, V.R. Praveen Kumar, Rakesh Kumar, Prabhakaran Kamalakannan, Anil K. Hajare, Neelima Sinha, Rajender Kumar Kamboj, Jayasagar Gundu, Sharad Sharma, Nilesh Khedkar, Arun R. Jagdale, Navnath P. Karche, Venkata P. Palle, Dipak Modi, Saif Wahid, Vamsi Pagdala, Kochumalayil Shaji George, Ganesh R. Jadhav, Gourhari Jana, Rohan Limaye, Baban Thube, Lakshmi Narasimham, Harshal Khanwalkar, Shashikant Pawar, Kumar V.S. Nemmani, Rajesh Gupta, Minakshi Singh, Ramesh Kale, Ajay R. Tilekar, Samiron Phukan, Dhananjay Bakhle, Pradipta Kumar

Publikováno v: Bioorganic & Medicinal Chemistry. 28:115819

The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is described. Compounds of structure I have good biochemical and cellular potency but suffered from inferior PK.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439561d9cd7678612504a2221cbc22
https://doi.org/10.1016/j.bmc.2020.115819

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