Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Kumar Selvarajoo"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background The transition from explanative modeling of fitted data to the predictive modeling of unseen data for systems biology endeavors necessitates the effective recovery of reaction parameters. Yet, the relative efficacy of optimization
Externí odkaz:
https://doaj.org/article/69b364aa894f44a6b204a9e42584b873
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Engineered microorganisms have emerged as viable alternatives for limonene production. However, issues such as low enzyme abundance or activities, and regulatory feedback/forward inhibition may reduce yields. To understand the underlying met
Externí odkaz:
https://doaj.org/article/42937daf53594e4886801272335a0d11
Publikováno v:
eLife, Vol 12 (2024)
Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes
Externí odkaz:
https://doaj.org/article/2b57d1c145b648d8b7946d59a7fc3cf5
Globally invariant behavior of oncogenes and random genes at population but not at single cell level
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Cancer is widely considered a genetic disease. Notably, recent works have highlighted that every human gene may possibly be associated with cancer. Thus, the distinction between genes that drive oncogenesis and those that are associated to t
Externí odkaz:
https://doaj.org/article/b3ed31fdf1c14368b69d4f5a3cc353d2
Autor:
Jasmeet Kaur Khanijou, Hanna Kulyk, Cécilia Bergès, Leng Wei Khoo, Pnelope Ng, Hock Chuan Yeo, Mohamed Helmy, Floriant Bellvert, Wee Chew, Kumar Selvarajoo
Publikováno v:
Metabolic Engineering Communications, Vol 15, Iss , Pp e00209- (2022)
Metabolic engineering involves the manipulation of microbes to produce desirable compounds through genetic engineering or synthetic biology approaches. Metabolomics involves the quantitation of intracellular and extracellular metabolites, where mass
Externí odkaz:
https://doaj.org/article/ca5357b363fb48d18d352284f9b9d68b
Autor:
Kumar Selvarajoo, Alessandro Giuliani
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1080 (2023)
For many years, there has been general interest in developing virtual cells or digital twin models [...]
Externí odkaz:
https://doaj.org/article/b520d33ca3e54ddda4e18929470f16ea
Autor:
Mohamed Helmy, Kumar Selvarajoo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The majority of human genome are non-coding genes. Recent research have revealed that about half of these genome sequences make up of transposable elements (TEs). A branch of these belong to the endogenous retroviruses (ERVs), which are germline vira
Externí odkaz:
https://doaj.org/article/b230c87e5de84a50ae77b63ff8bd2e52
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Gene expression profiling techniques, such as DNA microarray and RNA-Sequencing, have provided significant impact on our understanding of biological systems. They contribute to almost all aspects of biomedical research, including studying development
Externí odkaz:
https://doaj.org/article/299125d1b77446728f33b0e71e48ac52
Autor:
William Deveaux, Kumar Selvarajoo
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objective Living cells display complex and non-linear behaviors, especially when posed to environmental threats. Here, to understand the self-organizing cooperative behavior of a microorganism Pseudomonas aeruginosa, we developed a discrete
Externí odkaz:
https://doaj.org/article/e35bd21dd3b148098927c02fc50db2de
Publikováno v:
Metabolic Engineering Communications, Vol 11, Iss , Pp e00149- (2020)
Metabolic engineering aims to maximize the production of bio-economically important substances (compounds, enzymes, or other proteins) through the optimization of the genetics, cellular processes and growth conditions of microorganisms. This requires
Externí odkaz:
https://doaj.org/article/1d246dca0e564eb49a4e1e162f8245a2