Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kumar Reddy Kakularam"'
Autor:
Kumar Reddy Kakularam, Felix Karst, Aparoy Polamarasetty, Igor Ivanov, Dagmar Heydeck, Hartmut Kuhn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112434- (2022)
Lipoxygenases (ALOX-isoforms) are lipid peroxidizing enzymes, which have been implicated in cell differentiation and maturation but also in the biosynthesis of lipid mediators playing important roles in the pathogenesis of inflammatory, hyperprolifer
Externí odkaz:
https://doaj.org/article/ceedff28c8c34ca48c9278f1abd92056
Autor:
Thomas Horn, Kumar Reddy Kakularam, Monika Anton, Constanze Richter, Pallu Reddanna, Hartmut Kuhn
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 566-577 (2013)
Mammalian lipoxygenases play a role in normal cell development and differentiation but they have also been implicated in the pathogenesis of cardiovascular, hyperproliferative and neurodegenerative diseases. As lipid peroxidizing enzymes they are inv
Externí odkaz:
https://doaj.org/article/abcbe4f4dcdf424e8c6889e3289c51e6
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134472 (2015)
In this study we introduce a rescoring method to improve the accuracy of docking programs against mPGES-1. The rescoring method developed is a result of extensive computational study in which different scoring functions and molecular descriptors were
Externí odkaz:
https://doaj.org/article/3d1e804da3d64a6a8fb1738a7345747f
Autor:
Harshavardhan Bhuktar, Sharda Shukla, Kumar Reddy Kakularam, Srikanth Battu, Manupati Srikanth, Susmita Srivastava, Raghavender Medishetti, Pooja Ram, P.C. Jagadish, Mahaboobkhan Rasool, Sandipan Chakraborty, Nooruddin Khan, Pallu Reddanna, Srinivas Oruganti, Manojit Pal
Publikováno v:
Bioorganic Chemistry. 138:106606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1113554b37837d4a68cc0b8774611c
https://doi.org/10.1016/j.bioorg.2023.106606
https://doi.org/10.1016/j.bioorg.2023.106606
Publikováno v:
The FEBS Journal. 288:1387-1406
After 300 million years of evolution, the first land-living mammals reentered the marine environment some 50 million years ago. The driving forces for this dramatic lifestyle change are still a matter of discussion but the struggle for food resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a266855a6851b12f3f9ac52cbf90a08
https://doi.org/10.1111/febs.15469
https://doi.org/10.1111/febs.15469
Autor:
Kumar Reddy Kakularam, Dagmar Heydeck, Igor Ivanov, Hartmut Kühn, Aparoy Polamarasetty, Felix Karst
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112434-(2022)
Lipoxygenases (ALOX-isoforms) are lipid peroxidizing enzymes, which have been implicated in cell differentiation and maturation but also in the biosynthesis of lipid mediators playing important roles in the pathogenesis of inflammatory, hyperprolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8d8cf08c07eecf4c671571907f1e04
https://pubmed.ncbi.nlm.nih.gov/34801853
https://pubmed.ncbi.nlm.nih.gov/34801853
Autor:
Hartmut Kühn, Dagmar Heydeck, Michael Rothe, Elena V. Shmendel, Kumar Reddy Kakularam, Polamarasetty Aparoy, Igor Ivanov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1866:158918
Endocannabinoids, such as anandamide (ANA) and 2-arachidonoylglycerol (2AG), are lipid-signaling molecules that can be oxidized by lipid-peroxidizing enzymes, and this oxidation alters the bioactivity of these lipid mediators. Here, under strictly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6d323a5910bd1b546cf8741a9a1eb9
https://doi.org/10.1016/j.bbalip.2021.158918
https://doi.org/10.1016/j.bbalip.2021.158918
Publikováno v:
Protein & Peptide Letters. 22:903-912
Recent developments in the dual inhibition studies of cyclooxygenase-2 (COX-2) and carbonic anhydrase (CA-II) imply a promising platform for the development of new generations of nonsteroidal anti-inflammatory drugs (NSAIDs). CG100649 is such a molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc6f763e128cf75bcbc71f8f8ad45c9
https://doi.org/10.2174/0929866522666150622102131
https://doi.org/10.2174/0929866522666150622102131
Publikováno v:
Archives of Biochemistry and Biophysics. 565:17-24
Mammalian lipoxygenases (LOXs) have been implicated in cell differentiation and in the biosynthesis of pro- and anti-inflammatory lipid mediators. The initial draft sequence of the Homo neanderthalensis genome (coverage of 1.3-fold) suggested defecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf56974a5bdb25170fca82c1cbb5fc41
https://doi.org/10.1016/j.abb.2014.10.012
https://doi.org/10.1016/j.abb.2014.10.012
Autor:
Hartmut Kühn, Aparoy Polymarasetty, Katharina Hofheinz, Thomas Horn, Pallu Reddanna, Susan Adel, Monika Anton, Kumar Reddy Kakularam
Publikováno v:
Archives of Biochemistry and Biophysics. 530:40-47
5-Lipoxygenase (ALOX5) is a key enzyme in biosynthesis of pro-inflammatory leukotrienes whereas 15-lipoxygenases (ALOX15) have been implicated in the formation of pro-resolving eicosanoids (lipoxins, resolvins). Although mammalian LOX-isoforms share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20699777cb65d6c854c586bf1ccf5789
https://doi.org/10.1016/j.abb.2012.11.015
https://doi.org/10.1016/j.abb.2012.11.015