Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kumar Nagarathinam"'
Autor:
Kris Gerard Alvarez, Lisa Goral, Abdulhadi Suwandi, Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Katrin Ehrhardt, Kumar Nagarathinam, Katrin Künnemann, Thomas Krey, Agnes Wiedemann, Gisa Gerold, Guntram A. Grassl
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular loop domains. Tetraspanins are known as molecular facilitators, which assemble and organiz
Externí odkaz:
https://doaj.org/article/9dea300125274fc9b995bc95c8ce982c
Autor:
Alina Stadermann, Markus Haar, Armin Riecke, Thomas Mayer, Christian Neumann, Arthur Bauer, Ansgar Schulz, Kumar Nagarathinam, Niklas Gebauer, Svea Böhm, Miriam Groß, Michael Grunert, Matthias Müller, Hanno Witte
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2762 (2024)
Hemophagocytic lymphohistiocytosis (HLH) is a rare but in most cases life-threatening immune-mediated disease of the hematopoietic system frequently associated with hematologic neoplasms. Here, we report on a case in which we detected a novel constel
Externí odkaz:
https://doaj.org/article/febba51f98dc4947abe10b0796c1861b
Autor:
Axel Künstner, Julian Schwarting, Hanno M. Witte, Veronica Bernard, Stephanie Stölting, Kathrin Kusch, Kumar Nagarathinam, Nikolas von Bubnoff, Eva Maria Murga Penas, Hartmut Merz, Hauke Busch, Alfred C. Feller, Niklas Gebauer
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/faa1a529eac74b9581d43dc6b3933615
Autor:
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs, Mikio Tanabe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli an
Externí odkaz:
https://doaj.org/article/9c31b685bee4442382a7b84e7402aa22
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Numerous antibodies have been described that potently neutralize a broad range of hepatitis C virus (HCV) isolates and the majority of these antibodies target the binding site for the cellular receptor CD81 within the major HCV glycoprotein E2. A det
Externí odkaz:
https://doaj.org/article/b9d427829da445be845e15d1a5a52b74
Publikováno v:
Chemical Reviews
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active transporters. MFS transporters are responsible for transporting a broad spectrum of substrates, either down their concentration gradient or uphill using the
Autor:
So Iwata, Norimichi Nomura, Milton T. Stubbs, Yunhon Hotta, Yoshiko Nakada-Nakura, Kumar Nagarathinam, Kehong Liu, Frank Jaenecke, Mikio Tanabe
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 73:423-430
The active efflux of antibiotics by multidrug-resistance (MDR) transporters is a major pathway of drug resistance and complicates the clinical treatment of bacterial infections. MdfA is a member of the major facilitator superfamily (MFS) fromEscheric
Publikováno v:
The journal of physical chemistry. B. 123(4)
For a comprehensive understanding of the thermodynamic state functions describing the stability of a protein, the influence of the intensive properties of temperature and pressure has to be known. With the zinc-finger-containing Kti11, we found a sui
Autor:
Christoph Parthier, Norimichi Nomura, Yunhon Hotta, Takaaki Miyaji, Kumar Nagarathinam, Tohru Terada, Yoshiko Nakada-Nakura, Milton T. Stubbs, Hiroshi Omote, Mikio Tanabe, So Iwata, Narinobu Juge, Kehong Liu, Frank Jaenecke
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major facilitator superfamily (MFS)
Autor:
Frank, Jaenecke, Yoshiko, Nakada-Nakura, Kumar, Nagarathinam, Satoshi, Ogasawara, Kehong, Liu, Yunhon, Hotta, So, Iwata, Norimichi, Nomura, Mikio, Tanabe
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1700
A major hurdle in membrane protein crystallography is generating crystals diffracting sufficiently for structure determination. This is often attributed not only to the difficulty of obtaining functionally active protein in mg amounts but also to the