Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins

Autor: Degrado, William, Reig, AJ, Pires, MM, Snyder, RA, Wu, Y, Jo, H, Kulp, DW, Butch, SE, Calhoun, JR, Szyperski, TG, Solomon, EI

Publikováno v: Degrado, William; Reig, AJ; Pires, MM; Snyder, RA; Wu, Y; Jo, H; et al.(2012). Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5bm8c06z

De novo proteins provide a unique opportunity to investigate the structure-function relationships of metalloproteins in a minimal, well-defined and controlled scaffold. Here, we describe the rational programming of function in a de novo designed di-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6b19efee131e1c9c51d3de8dfa8bf3db
http://www.escholarship.org/uc/item/5bm8c06z

Structure and Sequence Engineering Approaches to Improve In Vivo Expression of Nucleic Acid-Delivered Antibodies.

Autor: Helble M; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA; Department of Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Chu J; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Flowers K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Trachtman AR; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Huynh A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Kim A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Shupin N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Hojecki CE; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Gary EN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Solieva S; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA; Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Parzych EM; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA; Department of Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kulp DW; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA; Department of Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: dwkulp@wistar.org., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, 19104, USA. Electronic address: dwkulp@wistar.org.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41.

Autor: Schiffner T; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, Germany., Phung I; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Ray R; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Irimia A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Tian M; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Swanson O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Lee JH; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Lee CD; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Marina-Zárate E; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Cho SY; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Huang J; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Skog PD; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Serra AM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Rantalainen K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Allen JD; School of Biological Sciences, University of Southampton, Southampton, UK., Baboo S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Rodriguez OL; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Himansu S; Moderna, Inc., Cambridge, MA, USA., Zhou J; Department of Computer Science, Dartmouth College, Hanover, NH, USA., Hurtado J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Flynn CT; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., McKenney K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Havenar-Daughton C; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Saha S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Shields K; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Schultze S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Smith ML; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Liang CH; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Toy L; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Pecetta S; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Lin YC; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Willis JR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Sesterhenn F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Kulp DW; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Hu X; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Cottrell CA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Zhou X; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Ruiz J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Wang X; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Nair U; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Kirsch KH; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Cheng HL; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Davis J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kalyuzhniy O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Liguori A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Diedrich JK; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Ngo JT; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Lewis V; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Phelps N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Tingle RD; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Spencer S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Georgeson E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Adachi Y; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Kubitz M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Eskandarzadeh S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Elsliger MA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Amara RR; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Atlanta, GA, USA., Landais E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Multi-omics Vaccine Evaluation Consortium, The Scripps Research Institute, La Jolla, CA, USA.; San Diego Center for AIDS Research, The Scripps Research Institute, La Jolla, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Carnathan DG; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Watson CT; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Yates JR 3rd; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Paulson JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton, UK., Grigoryan G; Department of Computer Science, Dartmouth College, Hanover, NH, USA.; Department of Biological Sciences, Dartmouth College, Hanover, NH, USA.; Generate Biomedicines, Inc., Somerville, MA, USA., Ward AB; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Sok D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Wilson IA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. wilson@scripps.edu., Batista FD; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA. fbatista1@mgh.harvard.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. fbatista1@mgh.harvard.edu., Crotty S; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA. shane@lji.org.; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA. shane@lji.org.; Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, CA, USA. shane@lji.org., Schief WR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. schief@scripps.edu.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA. schief@scripps.edu.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVD), The Scripps Research Institute, La Jolla, CA, USA. schief@scripps.edu.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA. schief@scripps.edu.; Moderna, Inc., Cambridge, MA, USA. schief@scripps.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Jul; Vol. 25 (7), pp. 1307.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene.

Autor: Roark RS, Habib R, Gorman J, Li H, Connell AJ, Bonsignori M, Guo Y, Hogarty MP, Olia AS, Sowers K, Zhang B, Bibollet-Ruche F, Callaghan S, Carey JW, Cerutti G, Harris DR, He W, Lewis E, Liu T, Mason RD, Park Y, Rando JM, Singh A, Wolff J, Lei QP, Louder MK, Doria-Rose NA, Andrabi R, Saunders KO, Seaman MS, Haynes BF, Kulp DW, Mascola JR, Roederer M, Sheng Z, Hahn BH, Shaw GM, Kwong PD, Shapiro L

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.

Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice.

Autor: Cottrell CA; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA., Hu X; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Moderna Therapeutics, Cambridge, MA 02139, USA., Lee JH; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Skog P; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Luo S; HHMI, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Flynn CT; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., McKenney KR; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Hurtado J; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA., Kalyuzhniy O; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Liguori A; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Willis JR; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Landais E; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Raemisch S; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Chen X; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Baboo S; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Himansu S; Moderna Therapeutics, Cambridge, MA 02139, USA., Diedrich JK; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Duan H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Cheng C; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Schiffner T; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Bader DLV; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Kulp DW; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Tingle R; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Georgeson E; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Eskandarzadeh S; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Alavi N; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Lu D; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Sincomb T; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Kubitz M; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Mullen TM; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Yates JR 3rd; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Paulson JC; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA., Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Alt FW; 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Publikováno v: Science translational medicine [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadn0223. Date of Electronic Publication: 2024 May 22.