Zobrazeno 1 - 10
of 884
pro vyhledávání: '"Kullervo Hynynen"'
Autor:
Jonathan Peng, Ari Partanen, Samuel Pichardo, Robert Staruch, Kaitlyn Perry, Merrylee McGuffin, Yuexi Huang, Kelvin KW. Chan, Shun Wong, Greg Czarnota, Kullervo Hynynen, William Chu
Publikováno v:
International Journal of Hyperthermia, Vol 41, Iss 1 (2024)
Introduction Pelvic recurrences from rectal cancer present a challenging clinical scenario. Hyperthermia represents an innovative treatment option in combination with concurrent chemoradiation to enhance therapeutic effect. We provide the initial res
Externí odkaz:
https://doaj.org/article/b284cece5fd34aa187919b1083085963
Autor:
Ying Meng, Lorraine V. Kalia, Suneil K. Kalia, Clement Hamani, Yuexi Huang, Kullervo Hynynen, Nir Lipsman, Benjamin Davidson
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 719 (2024)
This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to transiently permeabilize the blood-brain barrier (BBB) for drug delivery in neurological disorde
Externí odkaz:
https://doaj.org/article/8912977789b44ea4a1207fa3ce0029ee
Autor:
Flavia Venetucci Gouveia, Harriet Lea‐Banks, Isabelle Aubert, Nir Lipsman, Kullervo Hynynen, Clement Hamani
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 4, Pp 507-519 (2023)
Abstract Objective Alzheimer's disease (AD) is often associated with neuropsychiatric symptoms, including agitation and aggressive behavior. These symptoms increase with disease severity, ranging from 10% in mild cognitive impairment to 50% in patien
Externí odkaz:
https://doaj.org/article/d64ec9524ecf45268097721b3e7821bb
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract We present MiniVess, the first annotated dataset of rodent cerebrovasculature, acquired using two-photon fluorescence microscopy. MiniVess consists of 70 3D image volumes with segmented ground truths. Segmentations were created using traditi
Externí odkaz:
https://doaj.org/article/728957a9247d4a9099403bb2407601a3
Autor:
Rikke Hahn Kofoed, Kate Noseworthy, Kathleen Wu, Shuruthisai Sivadas, Lisa Stanek, Bradford Elmer, Kullervo Hynynen, Lamya S. Shihabuddin, Isabelle Aubert
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 167-184 (2022)
Magnetic resonance imaging-guided focused ultrasound combined with microbubbles injected in the bloodstream (MRIgFUS) temporarily increases the permeability of the blood-brain barrier (BBB), which facilitates the entry of intravenously administered a
Externí odkaz:
https://doaj.org/article/279dc757e6004b4ea517cfc14340221c
Autor:
Dennison Trinh, Joanne Nash, David Goertz, Kullervo Hynynen, Sharshi Bulner, Umar Iqbal, James Keenan
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1176-1183 (2022)
Background Delivery of viral vectors as gene therapies to treat neurodegenerative diseases has been hampered by the inability to penetrate the blood brain barrier (BBB) and invasive or non-targeted delivery options prone to inducing immune responses.
Externí odkaz:
https://doaj.org/article/829924003aa94284a5e1c9a07761be4d
Autor:
Kavya Parekh, Suzanne LeBlang, Javad Nazarian, Sabine Mueller, Stergios Zacharoulis, Kullervo Hynynen, Lauren Powlovich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 37, Iss , Pp 100876- (2023)
Diffuse Intrinsic Pontine Glioma (DIPG), now known as Diffuse Midline Glioma (DMG) is a devastating pediatric brain tumor with limited treatment options and a very poor prognosis. Despite more than 250 clinical trials aimed to treat children diagnose
Externí odkaz:
https://doaj.org/article/374f91498c22493ba54ea09e070978c6
Publikováno v:
Sensors, Vol 23, Iss 21, p 8760 (2023)
Convolutional neural networks (CNNs), initially developed for image processing applications, have recently received significant attention within the field of medical ultrasound imaging. In this study, passive cavitation imaging/mapping (PCI/PAM), whi
Externí odkaz:
https://doaj.org/article/0d3f55fb4c7e44e1832bc10e7216c874
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2077 (2023)
Drug-loaded perfluorocarbon nanodroplets (NDs) can be activated non-invasively by focused ultrasound (FUS) and allow for precise drug-delivery. Anesthetic-loaded NDs and transcranial FUS have previously achieved targeted neuromodulation. To assess th
Externí odkaz:
https://doaj.org/article/1f32c4bab4614e189412c14bb43bb21c
Autor:
Rikke Hahn Kofoed, Stefan Heinen, Joseph Silburt, Sonam Dubey, Chinaza Lilian Dibia, Miriam Maes, Elizabeth M. Simpson, Kullervo Hynynen, Isabelle Aubert
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 390-405 (2021)
Efficient disease-modifying treatments for Alzheimer disease, the most common form of dementia, have yet to be established. Gene therapy has the potential to provide the long-term production of therapeutic in the brain following a single administrati
Externí odkaz:
https://doaj.org/article/2fac79d9eff6473f8934f1dbcffeddbc