Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kuljeet Vaid"'
Autor:
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi, Michael R. Hayden
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo load
Externí odkaz:
https://doaj.org/article/3098d7176f61480fbe25947e9399afed
Autor:
Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt, Susan M Freier, Gene Hung, Punit P Seth, C Frank Bennett, Eric E Swayze, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107434 (2014)
Huntington disease (HD) is an inherited, fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The mutant protein causes neuronal dysfunction and degeneration resulting in motor dysfunction, cognitive decline, and
Externí odkaz:
https://doaj.org/article/df087f84149f4dfba0bfc4bdc1b0f552
Autor:
Xiaofan Qiu, Dagmar E. Ehrnhoefer, Roshni R. Singaraja, Shaun S. Sanders, Kuljeet Vaid, Michael R. Hayden, Niels H. Skotte, Srinivasaragavan Kannan, Chandra S. Verma
Publikováno v:
Cell Death & Differentiation. 24:433-444
Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease. Decreasing CASP6 activity may help to restore neuronal function in these and other diseas
Autor:
Mandi E. Schmidt, Nicholas S. Caron, Dagmar E. Ehrnhoefer, Kuljeet Vaid, Sabine Engemann, Amber L. Southwell, Sonia Franciosi, Safia Ladha, Yen T. Nguyen, Xiaofan Qiu, Niels H. Skotte, Michael R. Hayden, Dale D.O. Martin
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b09164b826943c339534b0936270e7b
Autor:
Holly Kordasiewicz, Michael R. Hayden, Clarence Frank Bennett, Crystal N. Doty, Erika B. Villanueva, Punit P. Seth, Kuljeet Vaid, Susan M. Freier, Niels H. Skotte, Eugenia Petoukhov, Amber L. Southwell, Jeffrey B. Carroll, Michael E. Østergaard, Eric E. Swayze, Andrew T. Watt, Yuanyun Xie
Publikováno v:
Molecular Therapy. 22:2093-2106
Huntington disease (HD) is a dominant, genetic neurodegenerative disease characterized by progressive loss of voluntary motor control, psychiatric disturbance, and cognitive decline, for which there is currently no disease-modifying therapy. HD is ca
Autor:
Shaun S. Sanders, Mandi E. Schmidt, Kuljeet Vaid, Elizabeth Conibear, Erich E. Wanker, Stefanie L. Butland, Dale D.O. Martin, Sean-Patrick Riechers, Michael R. Hayden, Rona K. Graham, Roshni R. Singaraja, David T.S. Lin
Publikováno v:
Human Molecular Genetics. 23:4142-4160
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 is dysfunctional in the presence of mutant HTT (mHTT), the caus
Autor:
Yu Deng, Nagat Bissada, Mahmoud A. Pouladi, Dagmar E. Ehrnhoefer, Sonia Franciosi, Amber L. Southwell, Kuljeet Vaid, Michael R. Hayden, Rona K. Graham
Publikováno v:
Journal of Huntington's Disease. 1:243-260
Background: The amelioration of behavioral and neuropathological deficits in mice expressing caspase-6-resistant (C6R) mutant huntingtin (mhtt), despite the presence of an expanded polyglutamine tract, highlights proteolysis of htt at the 586aa caspa
Autor:
Kun Huang, Roshni R. Singaraja, Crystal N. Doty, Junmei Wan, Michael R. Hayden, Nagat Bissada, Sonia Franciosi, R. Mark Henkelman, Shaun S. Sanders, Nicholas G. Davis, Renaldo C. Drisdel, Fiona B. Young, Jason P. Lerch, Kuljeet Vaid, Lynn A. Raymond, Rochelle M. Hines, William N. Green, Austen J. Milnerwood
Publikováno v:
Human Molecular Genetics. 20:3899-3909
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice disp
Autor:
Lynn A. Raymond, Michael R. Hayden, Rona K. Graham, X. W. Yang, M. Metzler, Nagat Bissada, Richard L.M. Faull, Yu Deng, Liang Wang, Michelle Gray, Catherine M. Cowan, Mahmoud A. Pouladi, Kuljeet Vaid, Jeffrey B. Carroll
Publikováno v:
The Journal of Neuroscience. 30:15019-15029
Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early neuropathological changes in brains of patients with Huntington's disease (HD). However, the relationship between caspase cleavage of htt and caspase activation pattern
Publikováno v:
Biology of Reproduction. 80:153-161
Tubulobulbar complexes are actin filament-rich plasma membrane protrusions that form at intercellular junctions in the seminiferous epithelium of the mammalian testis. They are proposed to internalize intact junctions during sperm release and during