Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B gene

Autor: Ogawara, K, Kuldo, JM, Oosterhuis, K, Kroesen, BJ, Rots, MG, Trautwein, C, Kimura, T, Haisma, HJ, Molema, G

Publikováno v: Arthritis Research and Therapy, 8(1):32. BioMed Central Ltd.

In order to selectively block nuclear factor kappa B (NF-kappa B)-dependent signal transduction in angiogenic endothelial cells, we constructed an alpha v beta 3 integrin specific adenovirus encoding dominant negative I kappa B (dnI kappa B) as a the

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https://research.rug.nl/en/publications/77dcdbe0-1d0b-487e-96c3-f53690fb59bc

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Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

Autor: Kowalski PS; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Zwiers PJ; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Morselt HW; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Kuldo JM; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Leus NG; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Ruiters MH; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands; Synvolux Therapeutics, L.J. Zielstraweg 1, Groningen, The Netherlands., Molema G; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands., Kamps JA; University of Groningen, University Medical Center Groningen, Dept. of Pathology & Medical Biology, Medical Biology Section, Laboratory for Endothelial Biomedicine & Vascular Drug Targeting Research, Groningen, The Netherlands. Electronic address: j.a.a.m.kamps@umcg.nl.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2014 Feb 28; Vol. 176, pp. 64-75. Date of Electronic Publication: 2014 Jan 03.

The potential of RNA-based therapy for kidney diseases.

Autor: Bondue, Tjessa¹, van den Heuvel, Lambertus^1,2, Levtchenko, Elena¹, Brock, Roland^3,4 roland.brock@radboudumc.nl

Publikováno v: Pediatric Nephrology. Feb2023, Vol. 38 Issue 2, p327-344. 18p. 4 Diagrams, 3 Charts.

Unique miRNome and transcriptome profiles underlie microvascular heterogeneity in mouse kidney.

Autor: Luxen, Matthijs, Zwiers, Peter J., Meester, Femke, Jongman, Rianne M., Kuiper, Timara, Moser, Jill, Pultar, Marianne, Skalicky, Susanna, Diendorfer, Andreas B., Hackl, Matthias, Meurs, Matijs van, Molema, Grietje

Publikováno v: American Journal of Physiology: Renal Physiology; Sep2023, Vol. 325 Issue 3, pF299-F316, 18p