The hTH-GFP reporter rat model for the study of Parkinson's disease.

Autor: Lorraine Iacovitti, Xiaotao Wei, Jingli Cai, Eric W Kostuk, Ruihe Lin, Alexander Gorodinsky, Philip Roman, Gretchen Kusek, Sonal S Das, Audrey Dufour, Terina N Martinez, Kuldip D Dave

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113151 (2014)

Parkinson disease (PD) is the second leading neurodegenerative disease in the US. As there is no known cause or cure for PD, researchers continue to investigate disease mechanisms and potential new therapies in cell culture and in animal models of PD

Externí odkaz: https://doaj.org/article/4d2f73f4e1f9464c9023cd5e0d39b7ae

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

Autor: Nicole K. Polinski, Terina N. Martinez, Sylvie Ramboz, Michael Sasner, Mark Herberth, Robert Switzer, Syed O. Ahmad, Lee J. Pelligrino, Sean W. Clark, Jacob N. Marcus, Sean M. Smith, Kuldip D. Dave, Mark A. Frasier

Publikováno v: Disease Models & Mechanisms, Vol 15, Iss 6 (2022)

Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and acc

Externí odkaz: https://doaj.org/article/2ff4a4f7438a460f8a91ec3fc7c58bc4

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease

Autor: Kuldip D. Dave, Shehan De Silva, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer, III, Syed O. Ahmad, Susan M. Sunkin, Dan Walker, Xiaoxia Cui, Daniel A. Fisher, Aaron M. McCoy, Kevin Gamber, Xiaodong Ding, Matthew S. Goldberg, Stanley A. Benkovic, Meredith Haupt, Marco A.S. Baptista, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier

Publikováno v: Neurobiology of Disease, Vol 70, Iss , Pp 190-203 (2014)

Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset Parkinson's disease (PD). As part of its strategy to provide more tools f

Externí odkaz: https://doaj.org/article/3b4ee316f83d4fc3bf43bea037f0fae8

Antemortem detection of Parkinson's disease pathology in peripheral biopsies using artificial intelligence

Autor: Maxim Signaevsky, Bahram Marami, Marcel Prastawa, Nabil Tabish, Megan A. Iida, Xiang Fu Zhang, Mary Sawyer, Israel Duran, Daniel G. Koenigsberg, Clare H. Bryce, Lana M. Chahine, Brit Mollenhauer, Sherri Mosovsky, Lindsey Riley, Kuldip D. Dave, Jamie Eberling, Chris S. Coffey, Charles H. Adler, Geidy E. Serrano, Charles L. White, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, Thomas G. Beach, John F. Crary

Publikováno v: Acta neuropathologica communications. 10(1)

The diagnosis of Parkinson’s disease (PD) is challenging at all stages due to variable symptomatology, comorbidities, and mimicking conditions. Postmortem assessment remains the gold standard for a definitive diagnosis. While it is well recognized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe149e8ece64065f1ea59b84b0d3b43
https://pubmed.ncbi.nlm.nih.gov/35164870

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study

Autor: Erik Stoops, Brit Mollenhauer, Hugo Vanderstichele, Jing Zhang, Charlotte E. Teunissen, Henrik Zetterberg, Niels Kruse, Adrian W. Schmid, Kuldip D. Dave, Leslie M. Shaw, Jill Dunty, Robert M. Umek, Frederick Du Bois Bowman, Samantha J. Hutten, Tanja Schubert, Kaj Blennow, Marc Moniatte, Omar M. A. El-Agnaf, Daniel Drake, Chris L. Smith, Jennifer Masucci, Peggy Taylor, Hilal A. Lashuel, Jimmy Duong

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, 149(1), 126-138. Wiley-Blackwell
Mollenhauer, B, Bowman, F D, Drake, D, Duong, J, Blennow, K, el-Agnaf, O, Shaw, L M, Masucci, J, Taylor, P, Umek, R M, Dunty, J M, Smith, C L, Stoops, E, Vanderstichele, H, Schmid, A W, Moniatte, M, Zhang, J, Kruse, N, Lashuel, H A, Teunissen, C, Schubert, T, Dave, K D, Hutten, S J & Zetterberg, H 2019, ' Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid – method comparison and round robin study ', Journal of Neurochemistry, vol. 149, no. 1, pp. 126-138 . https://doi.org/10.1111/jnc.14569

α-Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43396bf3f8003ad9c36ae22ae4055347
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056398164&origin=inward