Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Kulbhushan Tikoo"'
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-14 (2024)
Abstract Background Aberrant gluconeogenesis is considered among primary drivers of hyperglycemia under insulin resistant conditions, with multiple studies pointing towards epigenetic dysregulation. Here we examine the role of miR-721 and effect of e
Externí odkaz:
https://doaj.org/article/826d2df3143544d4b24bd5ff8c877fd4
Publikováno v:
Bone Reports, Vol 18, Iss , Pp 101680- (2023)
Type 2 diabetes (T2D) affects the functional behavior of vertebra bone by altering its structural and mechanical properties. The vertebral bones are responsible to carry the body weight and it remains under prolonged constant load which results to vi
Externí odkaz:
https://doaj.org/article/529871d4918e4345aaccb6ca78909968
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Breast cancer including triple negative breast cancer (TNBC) represents an important clinical challenge, as these tumours often develop resistance to conventional chemotherapeutics. MicroRNAs play a crucial role in cell-cycle regulation, dif
Externí odkaz:
https://doaj.org/article/21017d063cd444ca96f8a40f1130a66b
Autor:
J S Thakur, Soundappan Kathirvel, Samir Malhotra, Nusrat Shafiq, Jatinder Paul Singh Gill, Kulbhushan Tikoo, Shyam Biswal
Publikováno v:
International Journal of Noncommunicable Diseases, Vol 5, Iss 3, Pp 123-130 (2020)
Introduction: Pesticide exposure causes acute and chronic adverse health effects on humans affecting the Kelch ECH-associated protein (Keap1)- nuclear factor erythroid 2-related factor 2 (Nrf2) and other oxidative pathways. We assessed the Keap1-Nrf2
Externí odkaz:
https://doaj.org/article/6d176ff1ae3c46ec8f16735492466cfe
Autor:
Komal Sharma, Shams Aaghaz, Indresh Kumar Maurya, Shreya Singh, Shivaprakash M. Rudramurthy, Vinod Kumar, Kulbhushan Tikoo, Rahul Jain
Publikováno v:
Molecules, Vol 28, Iss 1, p 87 (2022)
Delineation of clinical complications secondary to fungal infections, such as cryptococcal meningitis, and the concurrent emergence of multidrug resistance in large population subsets necessitates the need for the development of new classes of antifu
Externí odkaz:
https://doaj.org/article/2f9f234ee3fd4f268ab2cdaf6638f048
Autor:
Ebenezer I. O. Ajayi, Olorunfemi R. Molehin, Omotade I. Oloyede, Vinod Kumar, Venkateswara R. Amara, Jasmine Kaur, Pinakin Karpe, Kulbhushan Tikoo
Publikováno v:
Clinical Phytoscience, Vol 5, Iss 1, Pp 1-9 (2019)
Abstract Background Non-alcoholic fatty liver disease, which occurs in people who are not alcohol drinkers, describes some of the pathogenic conditions that may be in the least characterized by simple steatosis or can be as serious as non-alcoholic s
Externí odkaz:
https://doaj.org/article/18e903efdc2f4f11b0335a921aeaf252
Autor:
Zahid Rafiq Bhat, Manvendra Kumar, Nisha Sharma, Umesh Prasad Yadav, Tashvinder Singh, Gaurav Joshi, Brahmam Pujala, Mohd Raja, Joydeep Chatterjee, Kulbhushan Tikoo, Sandeep Singh, Raj Kumar
Publikováno v:
Molecules, Vol 27, Iss 17, p 5540 (2022)
Tyrosine kinase inhibitors are validated therapeutic agents against EGFR-mutated non-small cell lung cancer (NSCLC). However, the associated critical side effects of these agents are inevitable, demanding more specific and efficient targeting agents.
Externí odkaz:
https://doaj.org/article/ff6a738439274ecfb17650390e6c5f81
Autor:
Praveer Sihota, Ram Naresh Yadav, Sumathi Poleboina, Vishwajeet Mehandia, Sanjay Kumar Bhadada, Kulbhushan Tikoo, Navin Kumar
Publikováno v:
JBMR Plus, Vol 4, Iss 10, Pp n/a-n/a (2020)
ABSTRACT Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, and bone fragility is one of them. To simulate human T2D and to investigate diabetic bone fragility, man
Externí odkaz:
https://doaj.org/article/dc9944efe6494315b23d78d583407684
Autor:
Sunil Bansal, Indresh Kumar Maurya, Nitin Yadav, Chaitanya Kumar Thota, Vinod Kumar, Kulbhushan Tikoo, Virander Singh Chauhan, Rahul Jain
Publikováno v:
ACS Omega, Vol 3, Iss 8, Pp 10019-10032 (2018)
Externí odkaz:
https://doaj.org/article/ce44b096da8c4802937c7c3fdef02295
Autor:
Manvendra Kumar, Gaurav Joshi, Sahil Arora, Tashvinder Singh, Sajal Biswas, Nisha Sharma, Zahid Rafiq Bhat, Kulbhushan Tikoo, Sandeep Singh, Raj Kumar
Publikováno v:
Molecules, Vol 26, Iss 5, p 1490 (2021)
A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9c as potent
Externí odkaz:
https://doaj.org/article/a2c5a397a2c640f19086505035070114