Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo.

Autor: Kulaj K; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Molecular Cell Biology, Institute for Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany., Harger A; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bauer M; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Molecular Cell Biology, Institute for Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany., Caliskan ÖS; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Gupta TK; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Chiang DM; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany., Milbank E; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; Molecular Cell Biology, Institute for Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany., Reber J; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., Karlas A; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Kotzbeck P; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University of Graz, Graz, Austria., Sailer DN; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Volta F; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Medicine and Surgery, University of Parma, Parma, Italy., Lutter D; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Prakash S; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Merl-Pham J; Metabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany., Ntziachristos V; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Hauner H; Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany., Pfaffl MW; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany., Tschöp MH; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Division of Metabolic Diseases, Department of Medicine, Technical University of Munich, Munich, Germany., Müller TD; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hauck SM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany., Engel BD; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany.; Biozentrum, University of Basel, Basel, Switzerland., Gerdes JM; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany., Pfluger PT; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit NeuroBiology of Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, Munich, Germany., Krahmer N; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Stemmer K; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany. kerstin.stemmer@med.uni-augsburg.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. kerstin.stemmer@med.uni-augsburg.de.; Molecular Cell Biology, Institute for Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany. kerstin.stemmer@med.uni-augsburg.de.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 09; Vol. 14 (1), pp. 709. Date of Electronic Publication: 2023 Feb 09.

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Autor: Zhang Q; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Delessa CT; Institute of Food, Nutrition and Health, Department of Health Sciences and Technology (D-HEST), ETH Zürich, Zurich, Switzerland., Augustin R; Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co., KG, Biberach/Riss, Germany., Bakhti M; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany., Colldén G; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada., Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Caceres CG; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grandl G; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Harger A; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Herzig S; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany; Molecular Metabolic Control, Technical University of Munich, Munich, Germany., Hofmann S; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, München, Germany., Holleman CL; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Jastroch M; Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden., Keipert S; Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden., Kleinert M; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Knerr PJ; Novo Nordisk Research Center Indianapolis, Indianapolis, IN 46241, USA., Kulaj K; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Legutko B; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Lickert H; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, School of Medicine, Klinikum Rechts der Isar, 81675 München, Germany., Liu X; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Luippold G; Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co., KG, Biberach/Riss, Germany., Lutter D; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Malogajski E; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Medina MT; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, School of Medicine, Klinikum Rechts der Isar, 81675 München, Germany., Mowery SA; Novo Nordisk Research Center Indianapolis, Indianapolis, IN 46241, USA., Blutke A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Perez-Tilve D; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Salinno C; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, School of Medicine, Klinikum Rechts der Isar, 81675 München, Germany., Sehrer L; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Tschöp MH; German Center for Diabetes Research (DZD), Neuherberg, Germany; Helmholtz Zentrum München, Neuherberg, Germany; Technische Universität München, München, Germany., Stemmer K; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN 46241, USA., Wolfrum C; Institute of Food, Nutrition and Health, Department of Health Sciences and Technology (D-HEST), ETH Zürich, Zurich, Switzerland., Müller TD; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, 72076 Tübingen, Germany. Electronic address: timo.mueller@helmholtz-muenchen.de.

Publikováno v: Cell metabolism [Cell Metab] 2021 Apr 06; Vol. 33 (4), pp. 833-844.e5. Date of Electronic Publication: 2021 Feb 10.

MicroRNA Profile of Mouse Adipocyte-Derived Extracellular Vesicles.

Autor: Röszer, Tamás¹ (AUTHOR) roszer.tamas@med.unideb.hu

Publikováno v: Cells (2073-4409). Aug2024, Vol. 13 Issue 15, p1298. 16p.

Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression.

Autor: Veluthakal, Rajakrishnan¹ (AUTHOR) desparza@coh.org, Esparza, Diana¹ (AUTHOR), Hoolachan, Joseph M.¹ (AUTHOR), Balakrishnan, Rekha¹ (AUTHOR), Ahn, Miwon¹ (AUTHOR), Oh, Eunjin¹ (AUTHOR), Jayasena, Chathurani S.¹ (AUTHOR), Thurmond, Debbie C.¹ (AUTHOR) rveluthakal@coh.org

Publikováno v: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 3, p1504. 30p.

Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains.

Autor: Esparza, Diana, Lima, Carinna, Abuelreich, Sarah, Ghaeli, Ima, Hwang, Jinhee, Oh, Eunjin, Lenz, Ayelet, Gu, Angel, Jiang, Nan, Kandeel, Fouad, Thurmond, Debbie C., Jovanovic-Talisman, Tijana

Publikováno v: Frontiers in Endocrinology; 2024, p1-17, 17p