Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity.

Autor: Malik Y; School of Biosciences, University of Kent, Canterbury, United Kingdom., Kulaberoglu Y; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Anver S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Javidnia S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Borland G; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Rivera R; School of Biosciences, University of Kent, Canterbury, United Kingdom., Cranwell S; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Medelbekova D; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Svermova T; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom., Thomson J; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Broughton S; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom., von der Haar T; School of Biosciences, University of Kent, Canterbury, United Kingdom., Selman C; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tullet JMA; School of Biosciences, University of Kent, Canterbury, United Kingdom., Alic N; Institute of Healthy Ageing, Research Department of Genetics Evolution and Environment, University College London, London, United Kingdom.

Publikováno v: PLoS biology [PLoS Biol] 2024 Oct 22; Vol. 22 (10), pp. e3002853. Date of Electronic Publication: 2024 Oct 22 (Print Publication: 2024).

The functional characterisation of MOB1-regulated Hippo core cassette kinase signalling

Autor: Kulaberoglu, Y.

The Hippo tumour suppressor pathway regulates tissue growth by co-ordinating cell death, proliferation and differentiation. The central Hippo core cassette consists of MST1/2, LATS1/2, NDR1/2 and MOB1, with recent studies of MOB1 knockout mice indica

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746405

RNA Polymerase III, Ageing and Longevity.

Autor: Kulaberoglu Y; Department of Genetics Evolution and Environment, Institute of Healthy Ageing, University College London, London, United Kingdom., Malik Y; Faculty of Natural Sciences, University of Kent, Canterbury, United Kingdom., Borland G; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom., Selman C; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom., Alic N; Department of Genetics Evolution and Environment, Institute of Healthy Ageing, University College London, London, United Kingdom., Tullet JMA; Faculty of Natural Sciences, University of Kent, Canterbury, United Kingdom.

Publikováno v: Frontiers in genetics [Front Genet] 2021 Jul 06; Vol. 12, pp. 705122. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).

Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro .

Autor: Frankel D; School of Engineering, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK., Davies M; School of Engineering, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK., Bhushan B; School of Engineering, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK., Kulaberoglu Y; Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK., Urriola-Munoz P; Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK., Bertrand-Michel J; MetaToulLipidomics Facility, INSERM UMR1048, Toulouse, France., Pergande MR; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA., Smith AA; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Preet S; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Park TJ; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Rankin KS; Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Cologna SM; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA., Kumita JR; Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK.; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Cenac N; IRSD, INSERM, INRA, INP-ENVT, Toulouse University 3 Paul Sabatier, Toulouse, France., St John Smith E; Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK.

Publikováno v: Aging [Aging (Albany NY)] 2020 Nov 04; Vol. 12 (21), pp. 22266-22290. Date of Electronic Publication: 2020 Nov 04.

MitomiRs: The Role of Mitochondrial miRNAs in Regulating Radiation-Induced Cellular Senescence.

Autor: Ibragimova, M. A.¹, Kussainova, A. A.¹, Aripova, A. A.¹, Bersimbaev, R. I.¹, Bulgakova, O. V.¹ ya.summer13@yandex.kz

Publikováno v: Bulletin of the L.N. Gumilyov Eurasian National University. Bioscience Series. 2024, Vol. 148 Issue 3, p145-165. 21p.