Opto-epigenetic modulation of DNA methylation with a photo-responsive small-molecule approach

Autor: Mao, Shiqing, Nguyen, Ha, Stewart, Sabrina, Kukwikila, Mikiembo, Jones, Sioned, Offenbartl-Stiegert, Daniel, Beck, Stephan, Howorka, Stefan, Balasubramanian, Shankar

Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as DNA methylation play a key role in this process. Controlled DNA methylation editing can be attained via genetic means

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477abcff82526a6298c5eca2d27754cb
https://www.repository.cam.ac.uk/handle/1810/289737

A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation.

Autor: Nguyen, Ha Phuong, Stewart, Sabrina, Kukwikila, Mikiembo N., Jones, Sioned Fôn, Offenbartl‐Stiegert, Daniel, Mao, Shiqing, Balasubramanian, Shankar, Beck, Stephan, Howorka, Stefan

Publikováno v: Angewandte Chemie International Edition; 5/13/2019, Vol. 58 Issue 20, p6620-6624, 5p

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A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.

Autor: Nguyen HP; Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK., Stewart S; UCL Cancer Institute, London, UK., Kukwikila MN; Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK., Jones SF; Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK., Offenbartl-Stiegert D; Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK., Mao S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.; Cancer Research (UK) Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, UK., Balasubramanian S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.; Cancer Research (UK) Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, UK., Beck S; UCL Cancer Institute, London, UK., Howorka S; Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 May 13; Vol. 58 (20), pp. 6620-6624. Date of Electronic Publication: 2019 Apr 12.