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Akademický článek

Minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): study protocol for a multicentre, stepped-wedge, cluster-randomised controlled trial

Autor: D. Stelzer, H. Binder, M. Glattacker, E. Graf, M. Hahn, M. Hollenbeck, K. Kaier, B. Kowall, N. Kuklik, G. Metzner, N. Mueller, L. Seiler, S. Stolpe, C. Blume

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-15 (2024)

Abstract Background Early identification of patients with chronic kidney disease (CKD) and advancing kidney insufficiency, followed by specialist care, can decelerate the progression of the disease. However, awareness of the importance and possible c

Externí odkaz: https://doaj.org/article/1b795b3c079840a78df87018cef92a50

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The Chromosome Passenger Complex (CPC) Components and Its Associated Pathways Are Promising Candidates to Differentiate Between Normosensitive and Radiosensitive ATM-Mutated Cells

Autor: Anne Dietz, Prabal Subedi, Omid Azimzadeh, Lukas Duchrow, Felix Kaestle, Juliane Paetzold, Sarah Katharina Payer, Sabine Hornhardt, Christine von Toerne, Stefanie M Hauck, Bettina Kempkes, Cornelia Kuklik-Roos, Danielle Brandes, Arndt Borkhardt, Simone Moertl, Maria Gomolka

Publikováno v: Biomarker Insights, Vol 19 (2024)

Background: Sensitivity to ionizing radiation differs between individuals, but there is a limited understanding of the biological mechanisms that account for these variations. One example of such mechanisms are the mutations in the ATM (mutated ataxi

Externí odkaz: https://doaj.org/article/eee7e60216cc4d2f8095fa44a32f3361

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Akademický článek

Update to the study protocol: minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): a multicentre, stepped-wedge, cluster-randomised controlled trial

Autor: D. Stelzer, H. Binder, M. Glattacker, E. Graf, M. Hahn, M. Hollenbeck, K. Kaier, B. Kowall, N. Kuklik, G. Metzner, N. Mueller, L. Seiler, S. Stolpe, C. Blume

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-2 (2024)

Abstract This document reports a brief update to the previously published protocol of the MinDial study. Trial registration German Clinical Trials Register DRKS00029691. Registered on 12 Sept. 2022, https://drks.de/search/en/trial/DRKS00029691 .

Externí odkaz: https://doaj.org/article/19c8bad893824fc99870e890dc9b2d12

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Evacuation trials from a double-deck electric train unit: Experimental data and sensitivity analysis

Autor: Najmanová, Hana, Pešková, Veronika, Kuklík, Lukáš, Bukáček, Marek, Hrabák, Pavel, Vašata, Daniel

Publikováno v: Safety Science, Volume 146, 2022, 105523, ISSN 0925-7535

Passenger trains represent a challenging environment in emergencies, with specific evacuation conditions resulting from the typical layout and interior design inherent to public transportation vehicles. This paper describes a dataset obtained in a fu

Externí odkaz: http://arxiv.org/abs/2202.11460

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Akademický článek

Use of continuous glucose monitoring in insulin-treated older adults with type 2 diabetes

Autor: Silmara A O Leite, Michael P Silva, Ana C R Lavalle, Maria C V Bertogy, Murilo Bastos, Suelen C Vieira Kuklik, Guillermo Umpierrez

Publikováno v: Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-7 (2023)

Abstract Background Few studies have reported the adherence to and efficacy of continuous glucose monitoring (CGM) for improving diabetes management in insulin-treated older adults with type 2 diabetes mellitus (T2DM). Methods Prospective observation

Externí odkaz: https://doaj.org/article/e0dccb09da7c4ba0954cc6bbc5a39492

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Controlled oxygenated rewarming as novel end‐ischemic therapy for cold stored liver grafts. A randomized controlled trial

Autor: Thomas Minor, Charlotte vonHorn, Hristo Zlatev, Fuat Saner, Melanie Grawe, Bastian Lüer, Eva‐Maria Huessler, Nils Kuklik, Andreas Paul

Publikováno v: Clinical and Translational Science, Vol 15, Iss 12, Pp 2918-2927 (2022)

Abstract Abrupt return to normothermia has been shown a genuine factor contributing to graft dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury of liver grafts by gentle warming‐up using ex vivo machine

Externí odkaz: https://doaj.org/article/8df2e2780bd14330a7accc246490feb5

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Outcome after intracranial hemorrhage under dabigatran and reversal with idarucizumab versus under vitamin-K-antagonists – the RIC-ICH study

Autor: Nils Kuklik, Anika Hüsing, Andreas Stang, Marcus Brinkmann, Christoph C. Eschenfelder, Christian Weimar, Hans-Christoph Diener

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

BackgroundIntracranial hemorrhage (ICH) is a rare but serious side effect associated with the use of oral anticoagulants, such as dabigatran. The specific reversal agent for dabigatran, idarucizumab, is available for the management of individuals wit

Externí odkaz: https://doaj.org/article/6be94cdf4d414fee988ca644c63e58b6

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