Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils

Autor: Kukka Aimonen, Monireh Imani, Mira Hartikainen, Satu Suhonen, Esa Vanhala, Carlos Moreno, Orlando J. Rojas, Hannu Norppa, Julia Catalán

Publikováno v: Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-21 (2022)

Abstract Background Cellulose nanofibrils (CNFs) have emerged as a sustainable and environmentally friendly option for a broad range of applications. The fibrous nature and high biopersistence of CNFs call for a thorough toxicity assessment, but it i

Externí odkaz: https://doaj.org/article/43976ff4c7d645cfb5bc8923a028ce44

HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Autor: Ana Tavares, Kukka Aimonen, Sophie Ndaw, Aleksandra Fučić, Julia Catalán, Radu Corneliu Duca, Lode Godderis, Bruno C. Gomes, Beata Janasik, Carina Ladeira, Henriqueta Louro, Sónia Namorado, An Van Nieuwenhuyse, Hannu Norppa, Paul T. J. Scheepers, Célia Ventura, Jelle Verdonck, Susana Viegas, Wojciech Wasowicz, Tiina Santonen, Maria João Silva, on behalf of the HBM4EU Chromates Study Team

Publikováno v: Toxics, Vol 10, Iss 8, p 483 (2022)

A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in ly

Externí odkaz: https://doaj.org/article/61753409f0654f479f0c74296f1d06b6

Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping

Autor: Nicklas Raun Jacobsen, Marit Ilves, Kenneth Klingenberg Barfod, Harri Alenius, Rambabu Atluri, Trine Berthing, Ulla Vogel, Julia Catalán, Alan J. Lawlor, Henrik Wolff, Niels Hadrup, Hannu Norppa, Hanna K. Lindberg, Keld Alstrup Jensen, Karin Sørig Hougaard, Nicklas Mønster Sahlgren, Kukka Aimonen

Publikováno v: Hadrup, N, Aimonen, K, Ilves, M, Lindberg, H, Atluri, R, Sahlgren, N M, Jacobsen, N R, Barfod, K K, Berthing, T, Lawlor, A, Norppa, H, Wolff, H, Jensen, K A, Hougaard, K S, Alenius, H, Catalan, J & Vogel, U 2021, ' Pulmonary toxicity of synthetic amorphous silica–effects of porosity and copper oxide doping ', Nanotoxicology, vol. 15, no. 1, pp. 96-113 . https://doi.org/10.1080/17435390.2020.1842932
Hadrup, N, Aimonen, K, Ilves, M, Lindberg, H, Atluri, R, Sahlgren, N M, Jacobsen, N R, Barfod, K K, Berthing, T, Lawlor, A, Norppa, H, Wolff, H, Jensen, K A, Hougaard, K S, Alenius, H, Catalan, J & Vogel, U 2021, ' Pulmonary toxicity of synthetic amorphous silica–effects of porosity and copper oxide doping ', Nanotoxicology, vol. 15, no. 1 . https://doi.org/10.1080/17435390.2020.1842932
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modifications act syne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5f5d58f7f6548ac38756ce28aacf99
https://doi.org/10.1080/17435390.2020.1842932

Sensitive method for endotoxin determination in nanomedicinal product samples

Autor: Paul Schwillens, Eric R. Gremmer, Louis van Bloois, Wim H. de Jong, Geertsma Re, Peter H. J. Keizers, Christina Giannakou, Kukka Aimonen, Rob J. Vandebriel, Julia Catalán, Margriet V. D. Z. Park

Publikováno v: Nanomedicine, 14(10), 1231-1246. Future Medicine Ltd.

Aim: Nanomaterials and nanomedicinal products tend to interfere with various commonly used assays, including regulatory required endotoxin detection methods for medicines. We developed a method to quantify endotoxin levels that is compatible with nan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67785743aa8643918419ec411fdc6219
https://doi.org/10.2217/nnm-2018-0339

Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel

Autor: Anne T. Saber, Maria Helena Guerra Andersen, Ulla Vogel, Caroline Hallas Hemmingsen, Camilla Sandal Sejbaek, Kukka Aimonen, Julia Catalán, Per Axel Clausen, Marie Frederiksen, Steffen Loft, Peter Møller, Joonas Koivisto, Niels E Ebbehøj

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Andersen, M H G, Saber, A T, Frederiksen, M, Clausen, P A, Sejbaek, C S, Hemmingsen, C H, Ebbehøj, N E, Catalán, J, Aimonen, K, Koivisto, J, Loft, S, Møller, P & Vogel, U 2021, ' Occupational exposure and markers of genetic damage, systemic inflammation and lung function : a Danish cross-sectional study among air force personnel ', Scientific Reports, vol. 11, no. 1, 17998 . https://doi.org/10.1038/s41598-021-97382-5
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Andersen, M H G, Saber, A T, Frederiksen, M, Clausen, P A, Sejbaek, C S, Hemmingsen, C H, Ebbehøj, N E, Catalan, J, Aimonen, K, Koivisto, J, Loft, S, Møller, P & Vogel, U 2021, ' Occupational exposure and markers of genetic damage, systemic inflammation and lung function : a Danish cross-sectional study among air force personnel ', Scientific Reports, vol. 11, no. 1, 17998 . https://doi.org/10.1038/s41598-021-97382-5

Air force ground crew personnel are potentially exposed to fuels and lubricants, as raw materials, vapours and combustion exhaust emissions, during operation and maintenance of aircrafts. This study investigated exposure levels and biomarkers of effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c75fdf01077b8fd39bfef797f3dad49
http://zaguan.unizar.es/record/118137