CEA cell adhesion molecule 5 enriches functional human hematopoietic stem cells capable of long-term multi-lineage engraftment

Autor: Kuiying Ma, Xuan Wang, Linjie Wu, Lingling Yu, Jinhui Ye, Xueling Li, Lili Geng, Zhongyu Shi, Huihui Yang, Xijuan Zhang, Yongjian Zhang, Shuchang Wu, Pengfei Yuan, Yingchi Zhang, Fang Dong, Sha Hao, Linping Hu, Wensheng Wei, Riguo Fang, Tao Cheng

Publikováno v: iScience, Vol 26, Iss 12, Pp 108561- (2023)

Summary: Hematopoietic stem cell (HSC) surface markers improve the understanding of cell identity and function. Here, we report that human HSCs can be distinguished by their expression of the CEA Cell Adhesion Molecule 5 (CEACAM5, CD66e), which serve

Externí odkaz: https://doaj.org/article/bf358c0bcb274e3fab860398a9c72498

The Generation of Transgenic Mice with Fat1 and Fad2 Genes that have their own Polyunsaturated Fatty Acid Biosynthetic Pathway

Autor: Yue Chen, Mei Mei, Peng Zhang, Kuiying Ma, Guangqi Song, Xin Ma, Tianchuang Zhao, Bo Tang, Hongsheng Ouyang, Guangpeng Li, Ziyi Li

Publikováno v: Cellular Physiology and Biochemistry, Vol 32, Iss 3, Pp 523-532 (2013)

Background: Microorganisms and higher plants possess their own omega-3 and omega-6 polyunsaturated fatty acid (PUFAs) biosynthetic pathways. The n-6 fatty acid desaturase gene fad-2 codes for the n-6 desaturase enzyme that coverts oleic acid (OA 18:1

Externí odkaz: https://doaj.org/article/d0ee4d0bda3c4f5380b39c933c4f3802

Ex vivo generated human T-lymphoid progenitors as a tool to accelerate immune reconstitution after partially HLA compatible hematopoietic stem cell transplantation or after gene therapy

Autor: Isabelle André, Kuiying Ma, Laura E. Simons, Chloé Couzin, Jean-Sébastien Diana, Ranjita Devi Moirangthem, Elisa Magrin, Alessandra Magnani, Marina Cavazzana

Publikováno v: Bone Marrow Transplantation. 54:749-755

Prolonged T-cell immunodeficiency following HLA- incompatible hematopoietic stem cell transplantation (HSCT) represents a major obstacle hampering the more widespread use of this approach. Strategies to fasten T-cell reconstitution in this setting ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e187a9794decd8aff2e5ade70d06a7ab
https://doi.org/10.1038/s41409-019-0599-9

Microtubule Polymerization Inhibition Enhances Human Hematopoietic Stem Cell Homing and Engraftment

Autor: Yongjian Zhang, Dong Wei, Pengfei Yuan, Xijuan Zhang, Chao Li, Penghui Xia, Kuiying Ma, Huihui Yang, Lingling Yu, Riguo Fang, Zhongyu Shi, Wei Zhang

Publikováno v: Blood. 138:3820-3820

Hematopoietic stem cells (HSCs) serve as the origin of the hematopoietic system, with the ability to differentiate into all blood cell lineages and self-renewal to sustain the hematopoiesis throughout life. Hematopoietic stem cell transplantation (HS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dff217dbd30862583af86299e586996b
https://doi.org/10.1182/blood-2021-149294

Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency

Autor: David Fenard, Ornellie Bernadin, Anais Girard-Gagnepain, Camille Lévy, Chantal Lagresle-Peyrou, Kuiying Ma, Rana Mhaidly, Hanem Sadek, Marina Cavazzana, Fouzia Amirache, Caroline Costa, Ranjita Devi Moirangthem, Isabelle André, François-Loïc Cosset, Els Verhoeyen, Christian Reimann, Didier Nègre, Agata Cieslak, Vahid Asnafi

Publikováno v: Blood Advances
Blood Advances, The American Society of Hematology, 2019, 3 (3), pp.461-475. ⟨10.1182/bloodadvances.2018027508⟩
Blood Advances, 2019, 3 (3), pp.461-475. ⟨10.1182/bloodadvances.2018027508⟩

T cells represent a valuable tool for treating cancers and infectious and inherited diseases; however, they are mainly short-lived in vivo. T-cell therapies would strongly benefit from gene transfer into long-lived persisting naive T cells or T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc71d6d3ddfc5a388ab66cb716a918bb
https://hal.archives-ouvertes.fr/hal-02365989