Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kuixi Zhu"'
Autor:
Julie P. Merchant, Kuixi Zhu, Marc Y. R. Henrion, Syed S. A. Zaidi, Branden Lau, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Despite decades of genetic studies on late-onset Alzheimer’s disease, the underlying molecular mechanisms remain unclear. To better comprehend its complex etiology, we use an integrative approach to build robust predictive (causal) network
Externí odkaz:
https://doaj.org/article/59af61a1276a4d158efbd9462249793a
Autor:
Mika P. Cadiz, Tanner D. Jensen, Jonathon P. Sens, Kuixi Zhu, Won-Min Song, Bin Zhang, Mark Ebbert, Rui Chang, John D. Fryer
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-20 (2022)
Abstract Background Microglia, the resident immune cells of the brain, play a critical role in numerous diseases, but are a minority cell type and difficult to genetically manipulate in vivo with viral vectors and other approaches. Primary cultures a
Externí odkaz:
https://doaj.org/article/70fe5434115e4f4790a320d8c93669da
Autor:
Megan H. Trager, Emanuelle Rizk, Sharon Rose, Kuixi Zhu, Branden Lau, Benjamin T. Fullerton, Jaya Pradhan, Michael Moore, Ayush C. Srivastava, Giselle Singer, Robyn Gartrell, Rui Chang, Larisa J. Geskin, Yvonne M. Saenger, Gary Goldenberg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The presence of actinic keratoses (AKs) increases a patient’s risk of developing squamous cell carcinoma by greater than six-fold. We evaluated the effect of topical treatment with imiquimod on the tumor microenvironment by measuring trans
Externí odkaz:
https://doaj.org/article/6bb5791204724714b50998aaf52add66
Autor:
Ivan Carcamo-Orive, Marc Y R Henrion, Kuixi Zhu, Noam D Beckmann, Paige Cundiff, Sara Moein, Zenan Zhang, Melissa Alamprese, Sunita L D'Souza, Martin Wabitsch, Eric E Schadt, Thomas Quertermous, Joshua W Knowles, Rui Chang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008491 (2020)
Insulin resistance (IR) precedes the development of type 2 diabetes (T2D) and increases cardiovascular disease risk. Although genome wide association studies (GWAS) have uncovered new loci associated with T2D, their contribution to explain the mechan
Externí odkaz:
https://doaj.org/article/c45804cefb884fd3b6173fff99721b01
Autor:
Julie P. Merchant, Kuixi Zhu, Marc Y.R. Henrion, Syed S.A. Zaidi, Lau Branden, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David A. Bennett, Nilüfer Ertekin-Taner, Tracy L. Young-Pearse, Rui Chang
SummaryDespite decades of genetic studies on late onset Alzheimer’s disease (LOAD), the molecular mechanisms of Alzheimer’s disease (AD) remain unclear. Furthermore, different cell types in the central nervous system (CNS) play distinct roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a87d44e5deedcfff4abfe4cb1558cb
https://doi.org/10.1101/2022.10.19.512949
https://doi.org/10.1101/2022.10.19.512949
Autor:
Kuixi Zhu, Qianying He, Sheng-Feng Tsai, Dinusha Maheepala Mudalige, Marc Y.R. Henrion, Syed S.A. Zaidi, Lau Branden, Andrew Tang, Mika P. Cadiz, Rachel Hodos-Nkhereanye, Sara Moein, Melissa L. Alamprese, David A. Bennett, Philip L. De Jager, John D. Frye, Nilu□fer Ertekin-Taner, Yu-Min Kuo, Patrick T. Ronaldson, Rui Chang
SummaryMicroglia, the innate immune cells of the brain, are essential determinants of late-onset Alzheimer’s Disease (LOAD) neuropathology. Here, we developed an integrative computational systems biology approach to construct causal network models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b6baba1fad4b7c1351b1701d149bb7
https://doi.org/10.1101/2022.10.19.512953
https://doi.org/10.1101/2022.10.19.512953
Autor:
Kuixi Zhu, Ayush C. Srivastava, Robyn D. Gartrell, Yvonne M. Saenger, Larisa J. Geskin, Branden Lau, Megan H. Trager, Michael Moore, Benjamin T. Fullerton, Sharon Rose, Rui Chang, Jaya Sarin Pradhan, Emanuelle M. Rizk, Gary Goldenberg, Giselle Singer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
The presence of actinic keratoses (AKs) increases a patient’s risk of developing squamous cell carcinoma by greater than six-fold. We evaluated the effect of topical treatment with imiquimod on the tumor microenvironment by measuring transcriptomic
Autor:
Rui, Chang, Eugenia, Trushina, Kuixi, Zhu, Syed Shujaat Ali, Zaidi, Branden M, Lau, Alexandra, Kueider-Paisley, Sara, Moein, Qianying, He, Melissa L, Alamprese, Barbora, Vagnerova, Andrew, Tang, Ramachandran, Vijayan, Yanyun, Liu, Andrew J, Saykin, Roberta D, Brinton, Rima, Kaddurah-Daouk
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic p
Autor:
Ivan Carcamo-Orive, Gabriel E. Hoffman, Paige Cundiff, Noam D. Beckmann, Sunita L. D’Souza, Joshua W. Knowles, Achchhe Patel, Caroline Hendry, Dimitri Papatsenko, Fahim Abbasi, Gerald M. Reaven, Sean Whalen, Philip Lee, Mohammad Shahbazi, Marc Y.R. Henrion, Kuixi Zhu, Sven Wang, Panos Roussos, Eric E. Schadt, Gaurav Pandey, Rui Chang, Thomas Quertermous, Ihor Lemischka
Publikováno v:
Cell Stem Cell. 29:1505
Autor:
Robyn Fong, Tiffany K Koyano, Trieu Nguyen, Manabu Nagao, Ramen Kundu, Robert C. Wirka, Milos Pjanic, John A. Coller, Rui Chang, Y. Joseph Woo, Stephen B. Montgomery, Juyong Brian Kim, Michelle D. Tallquist, Clint L. Miller, Boxiang Liu, Joseph C. Wu, Kuixi Zhu, Melissa Alamprese, David T. Paik, Thomas Quertermous, Dhananjay Wagh
Publikováno v:
Nature medicine
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo during atherosclerosis and the influence o