Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.

Autor: Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Zhou S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Liu P; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Yoon J; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Cox B; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Muzzarelli K; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Kuiper BD; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Kovari LC; Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: rschina@emory.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jul 01; Vol. 28 (12), pp. 2165-2170. Date of Electronic Publication: 2018 May 08.

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.

Autor: Kuiper BD; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Slater K; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Spellmon N; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Holcomb J; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Medapureddy P; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Muzzarelli KM; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Yang Z; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Ovadia R; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Kovari IA; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Kovari LC; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: kovari@med.wayne.edu.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Oct 28; Vol. 492 (4), pp. 668-673. Date of Electronic Publication: 2017 Mar 22.

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.

Autor: Kuiper BD; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA., Keusch BJ; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA., Dewdney TG; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA., Chordia P; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA.; Department of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA., Ross K; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA., Brunzelle JS; Life Sciences Collaborative Access Team and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA., Kovari IA; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA., MacArthur R; Department of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA., Salimnia H; Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA., Kovari LC; Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USA.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2015 Jun 12; Vol. 2, pp. 160-165. Date of Electronic Publication: 2015 Jun 12 (Print Publication: 2015).

Osthole activates glucose uptake but blocks full activation in L929 fibroblast cells, and inhibits uptake in HCLE cells.

Autor: Alabi OD; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA., Gunnink SM; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA., Kuiper BD; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA., Kerk SA; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA., Braun E; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA., Louters LL; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA. Electronic address: lout@calvin.edu.

Publikováno v: Life sciences [Life Sci] 2014 May 02; Vol. 102 (2), pp. 105-10. Date of Electronic Publication: 2014 Mar 21.

Hydroxylamine acutely activates glucose uptake in L929 fibroblast cells.

Autor: Louters LL; Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA. lout@calvin.edu, Scripture JP, Kuipers DP, Gunnink SM, Kuiper BD, Alabi OD

Publikováno v: Biochimie [Biochimie] 2013 Apr; Vol. 95 (4), pp. 787-92. Date of Electronic Publication: 2012 Nov 27.