Dihydropyrimidine dehydrogenase phenotyping using pretreatment uracil: a note of caution based on a large prospective clinical study

Autor: With, M. de, Knikman, J., Man, F.M. de, Lunenburg, C.A.T.C., Henricks, L.M., Kuilenburg, A.B.P. van, Maring, J.G., Staveren, M.C. van, Vries, N. de, Rosing, H., Beijnen, J.H., Pluim, D., Modak, A., Imholz, A.L.T., Schaik, R.H.N. van, Schellens, J.H.M., Gelderblom, H., Cats, A., Guchelaar, H.J., Mathijssen, R.H.J., Swen, J.J., Meulendijks, D.

Publikováno v: Clinical Pharmacology & Therapeutics, 112(1), 62-68. WILEY
Clinical Pharmacology and Therapeutics, 112(1), 62-68. Wiley-Blackwell
Clinical pharmacology and therapeutics, 112(1), 62-68. Wiley-Blackwell

In clinical practice, 25–30% of the patients treated with fluoropyrimidines experience severe fluoropyrimidine-related toxicity. Extensively clinically validated DPYD genotyping tests are available to identify patients at risk of severe toxicity du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e872538b1e1ef4d8d5d9938c0f590e
http://hdl.handle.net/1887/3515269

X-linked Charcot-Marie-Tooth disease, Arts syndrome, and prelingual non-syndromic deafness form a disease continuum: evidence from a family with a novel PRPS1 mutation

Autor: Synofzik, M., Muller vom Hagen, M., Haack, T.B., Wilhelm, C., Lindig, T., Beck-Wodl, S., Nabuurs, S.B., Kuilenburg, A.B.P. van, Brouwer, A.P.M. de, Schols, L.

Publikováno v: Orphanet Journal of Rare Diseases, 9, 1, pp. 24
Orphanet Journal of Rare Diseases, 9, 24

Contains fulltext : 136163.pdf (Publisher’s version ) (Open Access) BACKGROUND: X-linked Charcot-Marie-Tooth disease type 5 (CMTX5), Arts syndrome, and non-syndromic sensorineural deafness (DFN2) are allelic syndromes, caused by reduced activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ea83b5bd803df3bd9656b6d11e8b1b2a
https://hdl.handle.net/2066/136163

Cytidine Triphosphate Synthase Activity and mRNA Expression in Normal Human Blood Cells.

Autor: Verschuur, A.C., Gennip, A.H. Van, Muller, E.J., Voûte, P.A.T., Vreken, P., Kuilenburg, A.B.P. Van

Publikováno v: Biological Chemistry; Jan1999, Vol. 380 Issue 1, p41-46, 6p

The effect of the neuroblastoma-seeking agent meta -iodobenzylguanidine (MIBG) on NADH-driven superoxide formation and NADH-driven lipid peroxidation in beef heart submitochondrial particles

Autor: Cornelissen, J., Kuilenburg, A.B.P. Van, Vou^te, P.A., Gennip, A.H. Van

Publikováno v: European Journal of Cancer; 1997, Vol. 33 Issue: 3 p421-424, 4p

DPD screening to prevent toxicity in fluoropyrimidine treated patients

Autor: Staveren, M.C. van

Publikováno v: None

Fluoropyrimidines are being used in the treatment of different types of cancer. The most common fluoropyrimidine is 5-flourouracil (5-FU), which is administered intravenously as a bolus or as prolonged infusion. Many tissues throughout the body expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64a5998104505ce2185c7e7a83430cfd
http://hdl.handle.net/1887/44387