Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kuikui Zhou"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
The nucleus accumbens (NAc), a central component of the brain’s reward circuitry, has been implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that the function of
Externí odkaz:
https://doaj.org/article/21c71fdf953a4ca2a7d152d9ad55bb76
Autor:
Kuikui Zhou, Hua Xu, Shanshan Lu, Shaolei Jiang, Guoqiang Hou, Xiaofei Deng, Miao He, Yingjie Zhu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The nucleus accumbens (NAc) is involved in mediating reward seeking and negative valence. Here, the authors present evidence for afferent-specific circuitry of the NAc in the control of reward and aversion via two distinct pathway.
Externí odkaz:
https://doaj.org/article/ddbcd223fc9f41baa829ef09bab46de5
Autor:
Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112069- (2023)
Summary: The nucleus accumbens (NAc) plays an important role in motivation and reward processing. Recent studies suggest that different NAc subnuclei differentially contribute to reward-related behaviors. However, how reward is encoded in individual
Externí odkaz:
https://doaj.org/article/e94c9719c5214b39827338da64531465
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The brain continuously receives diverse information about the external environment and changes in the homeostatic state. The attribution of salience determines which stimuli capture attention and, therefore, plays an essential role in regulating emot
Externí odkaz:
https://doaj.org/article/d51543b323984d35826653f8fbf1ef4b
Autor:
Yadong Zhang, Xiangping Li, Kuikui Zhou, Mingkuan Zhou, Kai Xia, Yunlong Xu, Xiangzhou Sun, Yingjie Zhu, Chunyan Cui, Chunhua Deng
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Experimental autoimmune prostatitis (EAP) is a well-established model induced by an autoimmune response to prostate antigen. The symptomatic, pathological, and immunological characteristics of EAP animals are highly consistent with human chronic pros
Externí odkaz:
https://doaj.org/article/2702b044ed864be586bc653c64106ff4
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
Autor:
Saša Peter, Michiel M. ten Brinke, Jeffrey Stedehouder, Claudia M. Reinelt, Bin Wu, Haibo Zhou, Kuikui Zhou, Henk-Jan Boele, Steven A. Kushner, Min Goo Lee, Michael J. Schmeisser, Tobias M. Boeckers, Martijn Schonewille, Freek E. Hoebeek, Chris I. De Zeeuw
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype
Externí odkaz:
https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba7
Autor:
André R A Marques, Jan Aten, Roelof Ottenhoff, Cindy P A A van Roomen, Daniela Herrera Moro, Nike Claessen, María Fernanda Vinueza Veloz, Kuikui Zhou, Zhanmin Lin, Mina Mirzaian, Rolf G Boot, Chris I De Zeeuw, Herman S Overkleeft, Yildiz Yildiz, Johannes M F G Aerts
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135889 (2015)
The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly reduced GBA activity is associated with severe manifestations of Gaucher disease including neurological involvement. Mutations in the GBA gene have recent
Externí odkaz:
https://doaj.org/article/0c523c74cb7d4a758c1007928dd27117
Autor:
Yingjie Zhu, Kuikui Zhou
Publikováno v:
Pharmacological Research. 142:70-76
Drug addiction is a chronic relapsing brain disease characterized by compulsive, out-of-control drug use and the appearance of negative somatic and emotional consequences when drug access is prevented. The limited efficacy of treatment urges research
Autor:
Kuikui Zhou, Chunyan Cui, Ming-Kuan Zhou, Yingjie Zhu, Xiang-Ping Li, Xiangzhou Sun, Ya-Dong Zhang, Yunlong Xu, Kai Xia, Chunhua Deng
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Experimental autoimmune prostatitis (EAP) is a well-established model induced by an autoimmune response to prostate antigen. The symptomatic, pathological, and immunological characteristics of EAP animals are highly consistent with human chronic pros
Autor:
Rui M. Costa, María Fernanda Vinueza Veloz, Saša Peter, Simon E. Fisher, Catherine A. French, Kuikui Zhou, Chris I. De Zeeuw
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, 24(3), 447-462. Nature Publishing Group
Molecular Psychiatry, 24, 447-462
Molecular Psychiatry, 24, pp. 447-462
Molecular Psychiatry, 24, 447-462. Nature Publishing Group
Molecular Psychiatry, 24(3), 447-462. Nature Publishing Group
Molecular Psychiatry, 24, 447-462
Molecular Psychiatry, 24, pp. 447-462
Molecular Psychiatry, 24, 447-462. Nature Publishing Group
Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequencing orofacial movements. FOXP2 is expressed in cortico-striatal and cortico-cerebellar circuits important for fine motor skills, and affected individu