Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies

Autor: Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland

Publikováno v: Biomedicines, Vol 11, Iss 4, p 1133 (2023)

The survival rate of patients with osteosarcoma (OS) has not improved over the last 30 years. Mutations in the genes TP53, RB1 and c-Myc frequently occur in OS and enhance RNA Polymerase I (Pol I) activity, thus supporting uncontrolled cancer cell pr

Externí odkaz: https://doaj.org/article/828e24308c6e4101a33cd536ee4eaae4

Metastatic Leiomyoma With Malignant Transformation Harboring RAB2A-PLAG1 Fusion-A Case Report and Review With Molecular Analysis.

Autor: Lau HY; Department of Anatomical Pathology, Singapore General Hospital, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Pathology Academic Clinical Program, SingHealth Duke-NUS Academic Medical Centre, Singapore., Huang M; Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore., Chang KTE; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Pathology Academic Clinical Program, SingHealth Duke-NUS Academic Medical Centre, Singapore., Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Pathology Academic Clinical Program, SingHealth Duke-NUS Academic Medical Centre, Singapore., Takano A; Department of Anatomical Pathology, Singapore General Hospital, Singapore.; Pathology Academic Clinical Program, SingHealth Duke-NUS Academic Medical Centre, Singapore.

Publikováno v: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2024 Jul 29. Date of Electronic Publication: 2024 Jul 29.

CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication - evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours.

Autor: Aw SJ; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore. aw.sze.jet@singhealth.com.sg., Tan EEK; Paediatric Haematology/Oncology Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore., Low SYY; Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore., Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore., Goh JY; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore., Chang KTE; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 26; Vol. 12 (1), pp. 33. Date of Electronic Publication: 2024 Feb 26.

Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma.

Autor: Choo Z; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Koh X; Experimental Drug Development Centre, A*STAR, Singapore., Wong MRE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore., Ashokan RM; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ali Ahamed NSB; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kang C; Experimental Drug Development Centre, A*STAR, Singapore., Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore., Chang KTE; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore., Larisch S; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel., Loh AHP; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; Duke NUS Medical School, Singapore.; Cell Death and Cancer Research Laboratory, Department of Human Biology and Medical Sciences, University of Haifa, Haifa, Israel.; Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore., Chen ZX; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; VIVA-KKH Paediatric Brain and Solid Tumour Programme, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore.; National University Cancer Institute, Singapore, National University Health System, Singapore.

Publikováno v: Cancer research communications [Cancer Res Commun] 2023 Nov 22; Vol. 3 (11), pp. 2386-2399.

Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I.

Autor: Wong MRE; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore., Lim KH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hee EXY; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore., Chen H; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore., Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore., Aw SJ; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore., Chang KTE; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore; Duke-NUS School of Medicine, Singapore., Syed Sulaiman N; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore; Department of Neurology, National Neuroscience Institute, Singapore., Low SY; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore; Department of Neurology, National Neuroscience Institute, Singapore; Duke-NUS School of Medicine, Singapore., Hartono S; Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore., Tran ANT; Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore., Ahamed SH; Duke-NUS School of Medicine, Singapore; Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Singapore., Lam CMJ; Duke-NUS School of Medicine, Singapore; Department of Pediatric Subspecialties Hematology/Oncology Service, KK Women's and Children's Hospital, Singapore., Soh SY; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore; Duke-NUS School of Medicine, Singapore; Department of Pediatric Subspecialties Hematology/Oncology Service, KK Women's and Children's Hospital, Singapore., Hannan KM; Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, the Australian National University, Canberra, Australia; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia., Hannan RD; Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, the Australian National University, Canberra, Australia; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Coupland LA; Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, the Australian National University, Canberra, Australia., Loh AHP; VIVA-KKH Pediatric Brain and Solid Tumor Program, Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore; Duke-NUS School of Medicine, Singapore; Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore. Electronic address: amos.loh.h.p@singhealth.com.sg.

Publikováno v: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2023 Aug; Vol. 258, pp. 60-71. Date of Electronic Publication: 2023 Mar 14.