Výsledky vyhledávání - "Kui-Lea Park"

4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice

Autor: Wahn Soo Choi, Na Young Ko, Jun Ho Lee, Hyung Sik Kim, Bokyung Kim, Kui Lea Park, Do Kyun Kim, Hang Rae Kim, Young Mi Kim, Erk Her, Eun-Yi Moon, Hyuk Soon Kim, Aram Kim

Publikováno v: Toxicology and Applied Pharmacology. 257:235-241

4-Chlorotetrazolo[1,5-a]quinoxaline is a quinoxaline derivative. We aimed to study the effects of 4-chlorotetrazolo[1,5-a]quinoxaline on activation of mast cells in vitro and in mice. 4-Chlorotetrazolo[1,5-a]quinoxaline reversibly inhibited degranula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184994c33e60af7983a4289badedda89
https://doi.org/10.1016/j.taap.2011.09.009

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The Src Family Kinase Fgr Is Critical for Activation of Mast Cells and IgE-Mediated Anaphylaxis in Mice

Autor: Wahn Soo Choi, Young Mi Kim, Kui Lea Park, Dong Ki Park, Michael A. Beaven, Hyuk Soon Kim, Aram Kim, Hye-Jin Park, Jun Ho Lee, Bokyung Kim, Jie Wan Kim, Do Kyun Kim

Publikováno v: The Journal of Immunology. 187:1807-1815

Mast cells are critical for various allergic disorders. Mast cells express Src family kinases, which relay positive and negative regulatory signals by Ag. Lyn, for example, initiates activating signaling events, but it also induces inhibitory signals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2be28c7b0926fce57afbdc0a38e580a0
https://doi.org/10.4049/jimmunol.1100296

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Molecular Mechanism of Tetrabromobisphenol A (TBBPA)-induced Target Organ Toxicity in Sprague-Dawley Male Rats

Autor: Jae Seok Choi, Tae Cheon Jeong, Jae-Won Lee, Byung Mu Lee, Tae Hyung Kim, Mee Young Ahn, Hye Gwang Jeong, Hyun Jung Lim, Kui Lea Park, Young Jun Lee, Nam Deuk Kim, Sang Geum Kim, Seung Jun Kwack, Hyung Sik Kim, Tae Seok Kang

Publikováno v: Toxicological Research

Brominated flame retardants (BFRs) are present in many consumer products ranging from fabrics to plastics and electronics. Wide use of flame retardants can pose an environmental hazard, which makes it important to determine the mechanism of their tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31979c4cd26ba5358b209993025097ed
https://doi.org/10.5487/tr.2011.27.2.061

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Functional Role of Phospholipase D (PLD) in Di(2-Ethylhexyl) Phthalate-Induced Hepatotoxicity in Sprague-Dawley Rats

Autor: Seung Hee Kim, Tae Hyung Kim, Soon Young Han, Kui Lea Park, Seung Jun Kwack, Na Young Kim, Tae Seok Kang, Mi Ok Shin, Ena Lee, Jaewon Lee, Byung Mu Lee, Hyung Sik Kim, Nabanita Patra

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 73:1560-1569

Phospholipase D (PLD) is an enzyme that catalyzes the hydrolysis of phosphatidyl choline (PC) to generate phosphatidic acid (PA) and choline. PLD is believed to play an important role in cell proliferation, survival signaling, cell transformation, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807e5fadbe279a2a46b8099520bb4006
https://doi.org/10.1080/15287394.2010.511582

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Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method

Autor: Sang Min Yi, Sang Wook Son, Sang Hoon Jeong, Kyung Hee Sohn, Jae Hwan Kim, Meyoung Kon Kim, Jinho Kim, Kui Lea Park, Jung Pyo Lee

Publikováno v: Biochemical and Biophysical Research Communications. 394:612-615

Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This study investigated skin penetration of QDs in bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88fa3b5e51f9072c4d2883580adfa75
https://doi.org/10.1016/j.bbrc.2010.03.032

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Comparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats

Autor: Jae Seok Park, E.Y. Han, Byung Mu Lee, I.Y. Ahn, Tae Hyung Kim, J.Y. Bae, Hyun Jung Lim, Dong Eun Jang, Kui Lea Park, Seung Jun Kwack, Lan Choi, Hyung Sik Kim, Nabanita Patra, Seong Kwang Lim, Dong Hyun Kim

Publikováno v: Toxicological Research

This study was carried out to investigate the short term toxicity of nine phthalate diesters including di-2 (ethylhexyl) phthalate (DEHP) , di (n-butyl) phthalate (DBP) , di-n-octyl phthalate (DnOP) , diethyl phthalate (DEP) , butylbenzyl phthalate (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c83ec86c60d75dce8e65f256fcdfaa
https://doi.org/10.5487/tr.2010.26.1.075

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Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209

Autor: Seung Hee Kim, Ki Kyung Jung, Tae Sung Kim, Tae Hyung Kim, Mee Young Ahn, Jae Seok Choi, Tae Seok Kang, Kui Lea Park, Patra Nabanata, Seung Jun Kwack, Il Hyun Kang, Jaewon Lee, Ena Lee, Hyung Sik Kim, Byung Mu Lee, Na Young Kim

Publikováno v: ResearcherID

Our goal in the present study was to evaluate whether decabromodiphenyl ether (BDE-209), which is the most abundant polybrominated diphenyl ether (PBDE) found in human samples, affects against target organs. Sprague-Dawley male rats were exposed to v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec619e082087484c4dc64aaf01c58999
https://doi.org/10.2131/jts.35.535

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Assessment of dermal toxicity of nanosilica using cultured keratinocytes, a human skin equivalent model and an in vivo model

Autor: Sang Hoon Jeong, Byeong Hyeok Choi, Jae Eun Choi, Ji Na Kim, Sang Wook Son, Yoon Hee Park, Jung Pyo Lee, Kyung Hee Sohn, Kui Lea Park, Seungho Lee, Meyoung Kon Kim

Publikováno v: Toxicology. 267:178-181

Assessments of skin irritation potentials are important aspects of the development of nanotechnology. Nanosilica is currently being widely used for commercial purposes, but little literature is available on its skin toxicity and irritation potential.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b370ea409cf2c327a19b206956f49309
https://doi.org/10.1016/j.tox.2009.10.011

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Assessment of Heavy Metal Exposure Via the Intake of Oriental Medicines in Korea

Autor: JaYoung Kim, Eun Kyung Yoon, Junghoon Jang, Hyun-Kyung Kim, Tae Moo Yoo, Kui Lea Park, Myungsil Hwang, Dong Deuk Jang, Ji-Hye Ha

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 72:1336-1342

Oriental medical herbs are mainly natural products that are generated by simple processes, and therefore there is the possibility of contamination with various pollutants, including heavy metals. Heavy metals produce adverse effects in humans, and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ee24892ab4b56c3fb18ed4851e3fa
https://doi.org/10.1080/15287390903212485

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Suitability of macrophage inflammatory protein-1β production by THP-1 cells in differentiating skin sensitizers from irritant chemicals

Autor: Yeon-Mi Lim, Hyoung-Ah Kim, Kui-Lea Park, Seong-Joon Moon, Soojin Lee, Seoyoung Kim, Susun An, Ih-Seop Chang, Yong Heo

Publikováno v: Contact Dermatitis. 58:193-198

Background Worldwide restrictions in animal use for research have driven efforts to develop alternative methods. Objective The study aimed to test the efficacy of the macrophage inflammatory protein-1beta (MIP-1beta) assay for testing chemicals' skin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840d1f4a2d2b8720df7b62cf574e1d47
https://doi.org/10.1111/j.1600-0536.2007.01311.x

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